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A9GU24

- DNLI_SORC5

UniProt

A9GU24 - DNLI_SORC5

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Protein

Probable DNA ligase

Gene

lig

Organism
Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei211 – 2111ATPUniRule annotation
Active sitei213 – 2131N6-AMP-lysine intermediateUniRule annotation
Binding sitei218 – 2181ATPUniRule annotation
Binding sitei233 – 2331ATPUniRule annotation
Binding sitei262 – 2621ATPUniRule annotation
Binding sitei302 – 3021ATPUniRule annotation
Binding sitei374 – 3741ATPUniRule annotation
Binding sitei380 – 3801ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCEL448385:GJ75-7107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:sce6857
OrganismiSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Taxonomic identifieri448385 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium
ProteomesiUP000002139: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Probable DNA ligasePRO_0000365239Add
BLAST

Proteomic databases

PRIDEiA9GU24.

Interactioni

Protein-protein interaction databases

STRINGi448385.sce6857.

Structurei

3D structure databases

ProteinModelPortaliA9GU24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiIQSSPRY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9GU24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVSDLVATS ERVAALSRRV EKIGALAALL RRFSPAEVQI GVDWLTGRLR
60 70 80 90 100
QGRLGLGPSV FAEARRASPS VAQPALTLGD ADAVFTEIAR ASGPGAGGER
110 120 130 140 150
RAALAGLFAR ATDLERDFFA RLLAGELRQE RLEPVMVDAV ARAARVPPAS
160 170 180 190 200
LRRAVMLAGD AAEVVKAALL EGALGLQRFS LQLLRPVQPM LAQSADDVVT
210 220 230 240 250
ALSELRAMAL EWKLDGVRVQ AHKAGDEVRV FSRGLGPVTK AVPEIVEIVR
260 270 280 290 300
ALPVRSVVLD GEALAFRPDG APHPFQVTMR RFGRAHDAAA LRAELPLRAL
310 320 330 340 350
FFDVLHLDGE DLLDRPGSER TAALRQVLDR SLRVPRIELP TAAEAEAFFA
360 370 380 390 400
DALAHGHEGV IAKSLAAPYE AGRRRGTWLK VKRARTLDLV VLAAEWGTGR
410 420 430 440 450
RRGLLSNLHI GARDPAAGGF VLLGKTFKGM NDEVLAWQTQ RLLELEIGRD
460 470 480 490 500
ADTVYVRPEI VVEVAFDGLQ SSPRYPGGVA LRSARVKRYR PDKPAGEIST
510 520 530
MDEVRAIHAG ALAGEAAEKG QAEGGGEELE DDG
Length:533
Mass (Da):57,294
Last modified:February 5, 2008 - v1
Checksum:iA52A1D4621098BA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM746676 Genomic DNA. Translation: CAN97026.1.
RefSeqiYP_001617506.1. NC_010162.1.

Genome annotation databases

EnsemblBacteriaiCAN97026; CAN97026; sce6857.
GeneIDi5814087.
KEGGiscl:sce6857.
PATRICi23672589. VBISorCel80414_7491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM746676 Genomic DNA. Translation: CAN97026.1 .
RefSeqi YP_001617506.1. NC_010162.1.

3D structure databases

ProteinModelPortali A9GU24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 448385.sce6857.

Proteomic databases

PRIDEi A9GU24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAN97026 ; CAN97026 ; sce6857 .
GeneIDi 5814087.
KEGGi scl:sce6857.
PATRICi 23672589. VBISorCel80414_7491.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi IQSSPRY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci SCEL448385:GJ75-7107-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the myxobacterium Sorangium cellulosum."
    Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O., Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J., Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.
    , Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S., Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G., Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D., Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H., Puehler A., Mueller R.
    Nat. Biotechnol. 25:1281-1289(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: So ce56.

Entry informationi

Entry nameiDNLI_SORC5
AccessioniPrimary (citable) accession number: A9GU24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3