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A9GIT1 (PUR9_SORC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:sce3150
OrganismSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]
Taxonomic identifier448385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000076496

Sequences

Sequence LengthMass (Da)Tools
A9GIT1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: E4733BE708CFE02F

FASTA52254,941
        10         20         30         40         50         60 
MIRRALISVS DKTGLLPLAR RLAEKGVEIL STGGTQRALA DAGVPVIGVE AYTGSPEVMD 

        70         80         90        100        110        120 
GRVKTLHPRV HGGILMRGAI DDEDLARLGG APIDLVVCNL YPFEATVRKP GVTHPEIIEN 

       130        140        150        160        170        180 
IDIGGPSMVR SAAKNHARVA VVVDPADYDA VLAEIDRQGE VSSATRRRLA TKAFAHTAAY 

       190        200        210        220        230        240 
DGMVSGYLSS LPEEGEPSAA EREAYPRFLT LALERAYPLR YGENPHQSGA FYRERGAAAG 

       250        260        270        280        290        300 
SLALAESLGA GGKELSFNNL VDVDAAFEAV REFTQPAAVV VKHTNPCGVA TGDSLAAAYR 

       310        320        330        340        350        360 
TARDADAVSA FGGIVALNRE VDRAAAEVLV ETFLECVVAP AYTPDALEVL RTKKNLRLLA 

       370        380        390        400        410        420 
TGALLPADHR ELTFKRVGGG LVVQERDASA AGEVRGGRVV AKRAPTEEEI EALDLGWRVC 

       430        440        450        460        470        480 
KHVKSNAIVL AIPGRTVGIG AGQMSRVESV RIACSKAGER ARGSVLASDA FFPFPDNVVL 

       490        500        510        520 
AAEHGITAVA QPGGSVKDAE VIAAADAAGI AMVFTGARHF RH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM746676 Genomic DNA. Translation: CAN93309.1.
RefSeqYP_001613789.1. NC_010162.1.

3D structure databases

ProteinModelPortalA9GIT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING448385.sce3150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN93309; CAN93309; sce3150.
GeneID5804823.
KEGGscl:sce3150.
PATRIC23664435. VBISorCel80414_3430.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMALKSTLRY.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycSCEL448385:GJ75-3269-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_SORC5
AccessionPrimary (citable) accession number: A9GIT1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways