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Protein

Aspartokinase

Gene

lysC1

Organism
Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (sce9261), Aspartokinase (lysC2), Aspartokinase (lysC1)
  2. no protein annotated in this organism
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (sce9261), Aspartokinase (lysC2), Aspartokinase (lysC1)
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (hom)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (sce9261), Aspartokinase (lysC2), Aspartokinase (lysC1)
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSCEL448385:G1GJQ-2607-MONOMER
UniPathwayiUPA00034; UER00015
UPA00050; UER00461
UPA00051; UER00462

Names & Taxonomyi

Protein namesi
Recommended name:
AspartokinaseUniRule annotation (EC:2.7.2.4UniRule annotation)
Gene namesi
Name:lysC1Imported
Ordered Locus Names:sce2535Imported
OrganismiSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))Imported
Taxonomic identifieri448385 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium
Proteomesi
  • UP000002139 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi448385.sce2535

Structurei

3D structure databases

ProteinModelPortaliA9G6H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 356ACTInterPro annotationAdd BLAST94

Sequence similaritiesi

Belongs to the aspartokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFH Bacteria
COG0527 LUCA
HOGENOMiHOG000293093
KOiK00928
OMAiINIMMIS
OrthoDBiPOG091H0223

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR002912 ACT_dom
IPR001048 Asp/Glu/Uridylate_kinase
IPR005260 Asp_kin_monofn
IPR001341 Asp_kinase
IPR018042 Aspartate_kinase_CS
IPR027795 CASTOR_ACT_dom
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01842 ACT, 1 hit
PF13840 ACT_7, 1 hit
PIRSFiPIRSF000726 Asp_kin, 2 hits
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00656 asp_kin_monofn, 1 hit
TIGR00657 asp_kinases, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS00324 ASPARTOKINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A9G6H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIVQKFGG TSVGSIERIQ RAAARALATQ QAGHDVVVIV SAMSGETNRL
60 70 80 90 100
LKLASDIAPV PDAREMDALA ATGEQVSAAL MAIAIQAQGG KARSFLGHQL
110 120 130 140 150
KILTDSAYTK ARIKAIDAQR LHEALAGGKI AVVAGFQGVD DAGNITTLGR
160 170 180 190 200
GGSDTSAVAI AAAVGAECEI YTDVDGVYTT DPNICKTARK IERISYEEML
210 220 230 240 250
ELASLGAKVL QIRSVEVAMK YGVPVHVRSS FSDVPGTWVV SEEQSLESVT
260 270 280 290 300
VTGVALDRNE ARVMLVGVDD KPGVVAQIFG ALAEENISVD MIIQNAPSYG
310 320 330 340 350
LETRGTSGEV KADVTFTVGK ADLPRAKLVM EKVSSGVRAM SIRYEEDIVK
360 370 380 390 400
VSIVGLGMRT HAGVAARMFQ LLAAEGINIQ AISTSEIKIS CLVSTKYAEL
410
AVRALHDGFG LGGKA
Length:415
Mass (Da):43,529
Last modified:February 5, 2008 - v1
Checksum:i656E455269183D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM746676 Genomic DNA Translation: CAN92694.1
RefSeqiWP_012235167.1, NC_010162.1

Genome annotation databases

EnsemblBacteriaiCAN92694; CAN92694; sce2535
KEGGiscl:sce2535

Similar proteinsi

Entry informationi

Entry nameiA9G6H5_SORC5
AccessioniPrimary (citable) accession number: A9G6H5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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