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A9EZV5 (MDH_SORC5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:sce1050
OrganismSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]
Taxonomic identifier448385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Malate dehydrogenase HAMAP-Rule MF_00487
PRO_1000081366

Regions

Nucleotide binding11 – 166NAD By similarity
Nucleotide binding122 – 1243NAD By similarity

Sites

Active site1791Proton acceptor By similarity
Binding site351NAD By similarity
Binding site861Substrate By similarity
Binding site921Substrate By similarity
Binding site991NAD By similarity
Binding site1241Substrate By similarity
Binding site1551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A9EZV5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 2F8F421C9E666F08

FASTA31333,185
        10         20         30         40         50         60 
MANRRKIALI GAGNIGGELA ALIARKELGD VVLFDIPQKT DFAKGKALDL EQNGAVLGYD 

        70         80         90        100        110        120 
ASIKGTSSWA DCAGADVLIV TAGIPRKPGQ SRDDLVATNL PIIRSVADGA KEHCPNALVI 

       130        140        150        160        170        180 
VISNPIDAMV YEFKRRTGFP RERVLGMAGV LDSARFQLFL AREANVSVKD VRAMVLGGHG 

       190        200        210        220        230        240 
DDMVPIPSAC TINGVRATEL ISKEKLDALI ARTRKGGGEI VQLMGTSAYY APASSAVAMA 

       250        260        270        280        290        300 
ESYLLDQKRL LPVAAYLDGE YGYKDIFMGV PVILGGKGIE KIVELPLTAE EKEMLAKSAK 

       310 
SVQGITDVVK ASS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM746676 Genomic DNA. Translation: CAN91207.1.
RefSeqYP_001611687.1. NC_010162.1.

3D structure databases

ProteinModelPortalA9EZV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING448385.sce1050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN91207; CAN91207; sce1050.
GeneID5806541.
KEGGscl:sce1050.
PATRIC23659837. VBISorCel80414_1146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAFVGVPVI.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycSCEL448385:GJ75-1096-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_SORC5
AccessionPrimary (citable) accession number: A9EZV5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families