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A9EZV5

- MDH_SORC5

UniProt

A9EZV5 - MDH_SORC5

Protein

Malate dehydrogenase

Gene

mdh

Organism
Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei92 – 921SubstrateUniRule annotation
    Binding sitei99 – 991NADUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Active sitei179 – 1791Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation
    Nucleotide bindingi122 – 1243NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSCEL448385:GJ75-1096-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:sce1050
    OrganismiSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
    Taxonomic identifieri448385 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium
    ProteomesiUP000002139: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Malate dehydrogenasePRO_1000081366Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi448385.sce1050.

    Structurei

    3D structure databases

    ProteinModelPortaliA9EZV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiKTYAKDA.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9EZV5-1 [UniParc]FASTAAdd to Basket

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    MANRRKIALI GAGNIGGELA ALIARKELGD VVLFDIPQKT DFAKGKALDL    50
    EQNGAVLGYD ASIKGTSSWA DCAGADVLIV TAGIPRKPGQ SRDDLVATNL 100
    PIIRSVADGA KEHCPNALVI VISNPIDAMV YEFKRRTGFP RERVLGMAGV 150
    LDSARFQLFL AREANVSVKD VRAMVLGGHG DDMVPIPSAC TINGVRATEL 200
    ISKEKLDALI ARTRKGGGEI VQLMGTSAYY APASSAVAMA ESYLLDQKRL 250
    LPVAAYLDGE YGYKDIFMGV PVILGGKGIE KIVELPLTAE EKEMLAKSAK 300
    SVQGITDVVK ASS 313
    Length:313
    Mass (Da):33,185
    Last modified:February 5, 2008 - v1
    Checksum:i2F8F421C9E666F08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM746676 Genomic DNA. Translation: CAN91207.1.
    RefSeqiWP_012233684.1. NC_010162.1.
    YP_001611687.1. NC_010162.1.

    Genome annotation databases

    EnsemblBacteriaiCAN91207; CAN91207; sce1050.
    GeneIDi5806541.
    KEGGiscl:sce1050.
    PATRICi23659837. VBISorCel80414_1146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM746676 Genomic DNA. Translation: CAN91207.1 .
    RefSeqi WP_012233684.1. NC_010162.1.
    YP_001611687.1. NC_010162.1.

    3D structure databases

    ProteinModelPortali A9EZV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 448385.sce1050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAN91207 ; CAN91207 ; sce1050 .
    GeneIDi 5806541.
    KEGGi scl:sce1050.
    PATRICi 23659837. VBISorCel80414_1146.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi KTYAKDA.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci SCEL448385:GJ75-1096-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the myxobacterium Sorangium cellulosum."
      Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O., Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J., Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.
      , Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S., Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G., Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D., Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H., Puehler A., Mueller R.
      Nat. Biotechnol. 25:1281-1289(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: So ce56.

    Entry informationi

    Entry nameiMDH_SORC5
    AccessioniPrimary (citable) accession number: A9EZV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3