Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A9EYY7 (SYL_SORC5) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:sce7417
OrganismSorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]
Taxonomic identifier448385 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium

Protein attributes

Sequence length854 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 854854Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334822

Regions

Motif69 – 8012"HIGH" region HAMAP-Rule MF_00049
Motif633 – 6375"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9EYY7 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 0D0B4545E599E4D8

FASTA85495,563
        10         20         30         40         50         60 
MARRDMAAET MDPRASTEPS PNEPREPARY DHAAVEPRWQ RAWEEGETFR AVRSADPARG 

        70         80         90        100        110        120 
KRYVLDMFPY PSGSGLHVGH PEGYTATDIM SRYFRMRGID VLHVMGWDAF GLPAEQHALE 

       130        140        150        160        170        180 
TGTHPADTTA RNIATFKRQL KMLGFSYDWS RELSTTDPRY VRWTQWIFLQ LFKKGLAYQD 

       190        200        210        220        230        240 
EVSVNWCPAL GTVLANEEVI DGKSERGSHP VYRTPLRQWM LRITAYADRL AEDLRLLDWP 

       250        260        270        280        290        300 
EGTVAMQRSW IGRSEGALIT FEVKGWGKGA LSVFTTRPDT LMGVTYVVLA PEHPLTTWLT 

       310        320        330        340        350        360 
SAESGASEPR REAVRAYVAA AAGKSDRERL AAAAREKTGV DTGLVAVHPI TGVEVPIWVA 

       370        380        390        400        410        420 
DYVLGGYGTG AVMAVPGHDE RDFSFARTYG LPIVEVVSPD GSLHDQLEAA YVDPGVAVRS 

       430        440        450        460        470        480 
GEFDGLATEE CKRAVIARLE ALGRGKREVN YKLRDWVFSR QRYWGEPIPI YFPVELADPQ 

       490        500        510        520        530        540 
GDPRKGAAHT IRYDQPIAVD EASLPIELPP LADFRPGDDP AGPLARAVDW RFFQRDGKWY 

       550        560        570        580        590        600 
ARETNTMPQW AGSCWYYLRF LDPQNDAEPF SEAAYDAWMP VDLYVGGAEH GVLHLLYARF 

       610        620        630        640        650        660 
WHKVLYDLGH VKHPEPFAKL VHQGMILGED NEKMSKSRGN VINPDDIVRA HGADVLRMYE 

       670        680        690        700        710        720 
MFMGPLEAVK PWQSGQIQGV VRFRDRVFAT CTRPLSDAMD DATSRQLHRT IKKVTGDIEG 

       730        740        750        760        770        780 
MAFNTAISAM MVFVNHLSSL PSPPREAVLR LILLVSPFAP HLAEELWRLT GHERSLSYEP 

       790        800        810        820        830        840 
WPTYDEAFCV DDVLEIPVQV NGKVRGRVML AKAASEEEAR AAALGLETVA ALAAGKQLKK 

       850 
FIYVAGKIVN IVVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM746676 Genomic DNA. Translation: CAN97586.1.
RefSeqYP_001618066.1. NC_010162.1.

3D structure databases

ProteinModelPortalA9EYY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING448385.sce7417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN97586; CAN97586; sce7417.
GeneID5813722.
KEGGscl:sce7417.
PATRIC23673809. VBISorCel80414_8100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAVHRQSWP.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycSCEL448385:GJ75-7684-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_SORC5
AccessionPrimary (citable) accession number: A9EYY7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries