Reviewed, UniProtKB/Swiss-Prot A9EVN4 (UXUA_SORC5)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	sce4078

Organism

Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) [Complete proteome] [HAMAP]

Taxonomic identifier

448385 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Sorangiineae › Polyangiaceae › Sorangium

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Mannonate dehydratase HAMAP MF_00106		PRO_1000075905

Sequences

	Sequence		Length	Mass (Da)
	A9EVN4-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 88AFA540048D2095	FASTA	357	39,710
	10 20 30 40 50 60 MKMTFRWYGE NDPVKLEYIR QIPGIYGIVS AIYDVPVGEV WPVERLQALR ARVEGVGLRF 70 80 90 100 110 120 EVVESVPVHE DIKLGKPARE RLIDNFCQNI RNCAAAGVKV ICYNFMPVFD WTRTEMAREL 130 140 150 160 170 180 PDGSLTLAFD AAAVAEIDPE QGISLPGWDS SYRPEQLRAV LDEYKNVSEE ALWEHLEHFL 190 200 210 220 230 240 RRIIPVAEEV GVRMAMHPDD PPRPIFGLPR IVKNRDDLMR LVKTVDSPAN GITLCSGSLG 250 260 270 280 290 300 ADLCNNIVSL VREFGGMGRI PFGHLRNVAV QEDGTFFESA HLSCEGSLDM AAIVKAYHDV 310 320 330 340 350 GFDGYVRPDH GRMIWGETGK PGYGLYDRAL GLVYLNGLWE ATCKLSPGPA AKVPAPG

References

[1]

"Complete genome sequence of the myxobacterium Sorangium cellulosum." Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O., Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J., Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A. , Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S., Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G., Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D., Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H., Puehler A., Mueller R. Nat. Biotechnol. 25:1281-1289(2007) [PubMed: 17965706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM746676 Genomic DNA. Translation: CAN94241.1.
RefSeq	YP_001614721.1.
3D structure databases
SMR	A9EVN4. Positions 1-344.
ModBase	Search...
Genome annotation databases
GeneID	5805067.
GenomeReviews	Gene locus sce4078 in contig AM746676_GR.
KEGG	scl:sce4078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_SORC5

Accession

Primary (citable) accession number: A9EVN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	February 9, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)