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A9CSZ1

- SYEC_ENTBH

UniProt

A9CSZ1 - SYEC_ENTBH

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Protein
Probable glutamate--tRNA ligase, cytoplasmic
Gene
EBI_22577
Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei149 – 1491ATP By similarity
Binding sitei173 – 1731Glutamate By similarity
Binding sitei329 – 3291Glutamate By similarity
Binding sitei332 – 3321ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi367 – 3715ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
ORF Names:EBI_22577
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22577.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Probable glutamate--tRNA ligase, cytoplasmic
PRO_0000388392Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9CSZ1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1413Glutamate binding By similarity
Regioni311 – 3155Glutamate binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi144 – 15310"HIGH" region By similarity
Motifi367 – 3715"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7MKWFN.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9CSZ1-1 [UniParc]FASTAAdd to Basket

« Hide

MLENISKSEF VNFLLEKKHN IEPKTLPILE QHIREQKLDD FFLDFSIDFT    50
DEELNNFLSK LDYWLKNTKL NSSKADVIFG LLYSCNKFIK LIKNPTFSFV 100
EIKQFYNDIL NTNKNYIIEY NKKDKGKINI AVEGNVVTRF PPEPSGFLHI 150
GHIKAALLND LMAKNGKLLI RFDDTNPIKE EKMYENVIIE DLHTLGIKNY 200
TIVRSSDHFD SLYNYAIQLI QLGLAYCDNT DQLQMREERT KGIPSKNRNT 250
DIETNLSIFS KMSSGNCLDY CLRAKIDYTN LNKALRDPVI YRHIEKEHNI 300
TKNKYKIYPT YDFACPIIDS LDGVTLALRT NEYRDRNEQY YWFLEKLNLP 350
NKPKIYDFSR LNFENTVLSK RQMKFYVDNH FVSGWDDPRL STLRGILRLG 400
MDIDTLKEYI INQGSSQKSS VISWDKVWSL NKKNIDHKSA RYSAIPKLYC 450
VECLILDKNN NEIITKTEDI PKFKKNLSLG NKTIIKSSHI LISQEDANIL 500
NNNEEFTLMN WGNMKVKEKQ IVNGIIIKII LEENLAGDVK TTKNKLTWVN 550
KENIIEFKIL EYDTLQNDKN TDNLAEKFNT NSKKEEIWLG EKALISVSPK 600
TYIQIERIGF FICDKPLEFI LIPYTKQKRM R 631
Length:631
Mass (Da):73,962
Last modified:February 5, 2008 - v1
Checksum:i4DC6852631BEA04D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000003 Genomic DNA. Translation: EDQ31175.1.
RefSeqiXP_001828010.1. XM_001827958.1.

Genome annotation databases

GeneIDi6004350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000003 Genomic DNA. Translation: EDQ31175.1 .
RefSeqi XP_001828010.1. XM_001827958.1.

3D structure databases

ProteinModelPortali A9CSZ1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6004350.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_22577.

Phylogenomic databases

OrthoDBi EOG7MKWFN.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYEC_ENTBH
AccessioniPrimary (citable) accession number: A9CSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: November 13, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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