Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9CSZ1

- SYEC_ENTBH

UniProt

A9CSZ1 - SYEC_ENTBH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glutamate--tRNA ligase, cytoplasmic

Gene

EBI_22577

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei149 – 1491ATPBy similarity
Binding sitei173 – 1731GlutamateBy similarity
Binding sitei329 – 3291GlutamateBy similarity
Binding sitei332 – 3321ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi367 – 3715ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
ORF Names:EBI_22577
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
ProteomesiUP000001742: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22577.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Probable glutamate--tRNA ligase, cytoplasmicPRO_0000388392Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9CSZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1413Glutamate bindingBy similarity
Regioni311 – 3155Glutamate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi144 – 15310"HIGH" regionBy similarity
Motifi367 – 3715"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiA9CSZ1.
OrthoDBiEOG7MKWFN.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9CSZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLENISKSEF VNFLLEKKHN IEPKTLPILE QHIREQKLDD FFLDFSIDFT
60 70 80 90 100
DEELNNFLSK LDYWLKNTKL NSSKADVIFG LLYSCNKFIK LIKNPTFSFV
110 120 130 140 150
EIKQFYNDIL NTNKNYIIEY NKKDKGKINI AVEGNVVTRF PPEPSGFLHI
160 170 180 190 200
GHIKAALLND LMAKNGKLLI RFDDTNPIKE EKMYENVIIE DLHTLGIKNY
210 220 230 240 250
TIVRSSDHFD SLYNYAIQLI QLGLAYCDNT DQLQMREERT KGIPSKNRNT
260 270 280 290 300
DIETNLSIFS KMSSGNCLDY CLRAKIDYTN LNKALRDPVI YRHIEKEHNI
310 320 330 340 350
TKNKYKIYPT YDFACPIIDS LDGVTLALRT NEYRDRNEQY YWFLEKLNLP
360 370 380 390 400
NKPKIYDFSR LNFENTVLSK RQMKFYVDNH FVSGWDDPRL STLRGILRLG
410 420 430 440 450
MDIDTLKEYI INQGSSQKSS VISWDKVWSL NKKNIDHKSA RYSAIPKLYC
460 470 480 490 500
VECLILDKNN NEIITKTEDI PKFKKNLSLG NKTIIKSSHI LISQEDANIL
510 520 530 540 550
NNNEEFTLMN WGNMKVKEKQ IVNGIIIKII LEENLAGDVK TTKNKLTWVN
560 570 580 590 600
KENIIEFKIL EYDTLQNDKN TDNLAEKFNT NSKKEEIWLG EKALISVSPK
610 620 630
TYIQIERIGF FICDKPLEFI LIPYTKQKRM R
Length:631
Mass (Da):73,962
Last modified:February 5, 2008 - v1
Checksum:i4DC6852631BEA04D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000003 Genomic DNA. Translation: EDQ31175.1.
RefSeqiXP_001828010.1. XM_001827958.1.

Genome annotation databases

GeneIDi6004350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGB01000003 Genomic DNA. Translation: EDQ31175.1 .
RefSeqi XP_001828010.1. XM_001827958.1.

3D structure databases

ProteinModelPortali A9CSZ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6004350.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EBI_22577.

Phylogenomic databases

InParanoidi A9CSZ1.
OrthoDBi EOG7MKWFN.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
    Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
    PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.
  2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
    Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
    PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H348.

Entry informationi

Entry nameiSYEC_ENTBH
AccessioniPrimary (citable) accession number: A9CSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3