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Protein

Probable glutamate--tRNA ligase, cytoplasmic

Gene

EBI_22577

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149ATPBy similarity1
Binding sitei173GlutamateBy similarity1
Binding sitei329GlutamateBy similarity1
Binding sitei332ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 371ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
ORF Names:EBI_22577
OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Taxonomic identifieri481877 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaEnterocytozoonidaeEnterocytozoon
Proteomesi
  • UP000001742 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:EBI_22577

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003883921 – 631Probable glutamate--tRNA ligase, cytoplasmicAdd BLAST631

Proteomic databases

PRIDEiA9CSZ1

Structurei

3D structure databases

ProteinModelPortaliA9CSZ1
SMRiA9CSZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 141Glutamate bindingBy similarity3
Regioni311 – 315Glutamate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi144 – 153"HIGH" regionBy similarity10
Motifi367 – 371"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiA9CSZ1
OrthoDBiEOG092C0OTH

Family and domain databases

Gene3Di2.40.240.10, 2 hits
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9CSZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENISKSEF VNFLLEKKHN IEPKTLPILE QHIREQKLDD FFLDFSIDFT
60 70 80 90 100
DEELNNFLSK LDYWLKNTKL NSSKADVIFG LLYSCNKFIK LIKNPTFSFV
110 120 130 140 150
EIKQFYNDIL NTNKNYIIEY NKKDKGKINI AVEGNVVTRF PPEPSGFLHI
160 170 180 190 200
GHIKAALLND LMAKNGKLLI RFDDTNPIKE EKMYENVIIE DLHTLGIKNY
210 220 230 240 250
TIVRSSDHFD SLYNYAIQLI QLGLAYCDNT DQLQMREERT KGIPSKNRNT
260 270 280 290 300
DIETNLSIFS KMSSGNCLDY CLRAKIDYTN LNKALRDPVI YRHIEKEHNI
310 320 330 340 350
TKNKYKIYPT YDFACPIIDS LDGVTLALRT NEYRDRNEQY YWFLEKLNLP
360 370 380 390 400
NKPKIYDFSR LNFENTVLSK RQMKFYVDNH FVSGWDDPRL STLRGILRLG
410 420 430 440 450
MDIDTLKEYI INQGSSQKSS VISWDKVWSL NKKNIDHKSA RYSAIPKLYC
460 470 480 490 500
VECLILDKNN NEIITKTEDI PKFKKNLSLG NKTIIKSSHI LISQEDANIL
510 520 530 540 550
NNNEEFTLMN WGNMKVKEKQ IVNGIIIKII LEENLAGDVK TTKNKLTWVN
560 570 580 590 600
KENIIEFKIL EYDTLQNDKN TDNLAEKFNT NSKKEEIWLG EKALISVSPK
610 620 630
TYIQIERIGF FICDKPLEFI LIPYTKQKRM R
Length:631
Mass (Da):73,962
Last modified:February 5, 2008 - v1
Checksum:i4DC6852631BEA04D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGB01000003 Genomic DNA Translation: EDQ31175.1
RefSeqiXP_001828010.1, XM_001827958.1

Genome annotation databases

EnsemblFungiiEDQ31175; EDQ31175; EBI_22577

Similar proteinsi

Entry informationi

Entry nameiSYEC_ENTBH
AccessioniPrimary (citable) accession number: A9CSZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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