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A9CSU5

- SYQ_ENTBH

UniProt

A9CSU5 - SYQ_ENTBH

Protein

Probable glutamine--tRNA ligase

Gene

EBI_22570

Organism
Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei439 – 4391ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamine--tRNA ligase (EC:6.1.1.18)
    Alternative name(s):
    Glutaminyl-tRNA synthetase
    Short name:
    GlnRS
    Gene namesi
    ORF Names:EBI_22570
    OrganismiEnterocytozoon bieneusi (strain H348) (Microsporidian parasite)
    Taxonomic identifieri481877 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon
    ProteomesiUP000001742: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:EBI_22570.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Probable glutamine--tRNA ligasePRO_0000388382Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA9CSU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi196 – 20611"HIGH" regionBy similarityAdd
    BLAST
    Motifi436 – 4405"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7MD4ZK.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9CSU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLDDKLRGI SLSDEKINEL KTKPNLIKNM EVIVNTGNNF TKMQYSLACI    50
    APKNCNLIEL SNLIEEGYVT NDSLLKGLVK LGKKSKDEYI DFCKKHTYNE 100
    QDIINFIRLL KEKKETKATI SSKLKEQYLY YDTKIFLKEM ENYNLNVPME 150
    KYTKNWLDEG EIKFLHKPGE NPQKTKKIME DHLKRTGGKV ITRFPPEPNG 200
    NLHIGHAKAL NLSFEYAKKF NGITYLRFDD TNPKNESNEL YNGIIEDVKW 250
    LGFEPYAITA SSDHFEAMHE MAKTLIKKNK SYVCFCSLEE IRARRSKYQK 300
    ERDEGNDDPL ILSPYRNTSV EQNLIEFEKM LKGEYKDGEA VLRFKMPLKS 350
    KNPLMLDLVG ARIINMVHDR KQKNYIVYPS YEFALCVCDS LEDITHSFCS 400
    REFYTRQEPY HWLLQELDMY EPVQWEFSRL NISNTVLSKR KLTKIVDEGL 450
    NWDDPRFYTI KGMRRRGFPA SAINKFVQSV GITFSETIID VKILESFVLK 500
    ELMQIAKKAT CIINPLKVYI NKCTTGIISN EPVDVNNIIY IDKDDFDETN 550
    NSDFLRLTKI QPVGLINLGV LKYIKDESDG IRCELLTVDE CKPNKFIQWL 600
    PNLDNKVELR MYKPLFKSFD PDEIGYMNDI DLTNSLEIID GYVDNTVLNT 650
    HIEDKFQFIR IGFFCCDFDS IINDNQKKLV FNLTLPLNKN Y 691
    Length:691
    Mass (Da):80,660
    Last modified:February 5, 2008 - v1
    Checksum:i1F11DE3091ADF9CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000003 Genomic DNA. Translation: EDQ31158.1.
    RefSeqiXP_001827993.1. XM_001827941.1.

    Genome annotation databases

    GeneIDi6004333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGB01000003 Genomic DNA. Translation: EDQ31158.1 .
    RefSeqi XP_001827993.1. XM_001827941.1.

    3D structure databases

    ProteinModelPortali A9CSU5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6004333.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:EBI_22570.

    Phylogenomic databases

    OrthoDBi EOG7MD4ZK.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
      Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
      PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.
    2. "Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
      Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
      PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H348.

    Entry informationi

    Entry nameiSYQ_ENTBH
    AccessioniPrimary (citable) accession number: A9CSU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3