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A9CSU5 (SYQ_ENTBH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutamine--tRNA ligase

EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
ORF Names:EBI_22570
OrganismEnterocytozoon bieneusi (strain H348) (Microsporidian parasite) [Complete proteome]
Taxonomic identifier481877 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaEnterocytozoonidaeEnterocytozoon

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA aminoacylation for protein translation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Probable glutamine--tRNA ligase
PRO_0000388382

Regions

Motif196 – 20611"HIGH" region By similarity
Motif436 – 4405"KMSKS" region By similarity

Sites

Binding site4391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9CSU5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 1F11DE3091ADF9CF

FASTA69180,660
        10         20         30         40         50         60 
MNLDDKLRGI SLSDEKINEL KTKPNLIKNM EVIVNTGNNF TKMQYSLACI APKNCNLIEL 

        70         80         90        100        110        120 
SNLIEEGYVT NDSLLKGLVK LGKKSKDEYI DFCKKHTYNE QDIINFIRLL KEKKETKATI 

       130        140        150        160        170        180 
SSKLKEQYLY YDTKIFLKEM ENYNLNVPME KYTKNWLDEG EIKFLHKPGE NPQKTKKIME 

       190        200        210        220        230        240 
DHLKRTGGKV ITRFPPEPNG NLHIGHAKAL NLSFEYAKKF NGITYLRFDD TNPKNESNEL 

       250        260        270        280        290        300 
YNGIIEDVKW LGFEPYAITA SSDHFEAMHE MAKTLIKKNK SYVCFCSLEE IRARRSKYQK 

       310        320        330        340        350        360 
ERDEGNDDPL ILSPYRNTSV EQNLIEFEKM LKGEYKDGEA VLRFKMPLKS KNPLMLDLVG 

       370        380        390        400        410        420 
ARIINMVHDR KQKNYIVYPS YEFALCVCDS LEDITHSFCS REFYTRQEPY HWLLQELDMY 

       430        440        450        460        470        480 
EPVQWEFSRL NISNTVLSKR KLTKIVDEGL NWDDPRFYTI KGMRRRGFPA SAINKFVQSV 

       490        500        510        520        530        540 
GITFSETIID VKILESFVLK ELMQIAKKAT CIINPLKVYI NKCTTGIISN EPVDVNNIIY 

       550        560        570        580        590        600 
IDKDDFDETN NSDFLRLTKI QPVGLINLGV LKYIKDESDG IRCELLTVDE CKPNKFIQWL 

       610        620        630        640        650        660 
PNLDNKVELR MYKPLFKSFD PDEIGYMNDI DLTNSLEIID GYVDNTVLNT HIEDKFQFIR 

       670        680        690 
IGFFCCDFDS IINDNQKKLV FNLTLPLNKN Y 

« Hide

References

[1]"Patterns of genome evolution among the microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi."
Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S., Keeling P.J.
PLoS ONE 2:E1277-E1277(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H348.
[2]"Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi."
Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N., Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.
PLoS Pathog. 5:E1000261-E1000261(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H348.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABGB01000003 Genomic DNA. Translation: EDQ31158.1.
RefSeqXP_001827993.1. XM_001827941.1.

3D structure databases

ProteinModelPortalA9CSU5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6004333.

Organism-specific databases

EuPathDBMicrosporidiaDB:EBI_22570.

Phylogenomic databases

OrthoDBEOG7MD4ZK.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYQ_ENTBH
AccessionPrimary (citable) accession number: A9CSU5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: November 13, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries