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A9CMC8

- A9CMC8_RAT

UniProt

A9CMC8 - A9CMC8_RAT

Protein
Submitted name:

Lactase-phlorizin hydrolase

Gene

Lct

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lactase-phlorizin hydrolaseImported
    Submitted name:
    Lct proteinImported
    Gene namesi
    Name:LctImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi620823. Lct.

    Expressioni

    Gene expression databases

    GenevestigatoriA9CMC8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074452.
    HOVERGENiHBG006290.
    KOiK01229.
    OMAiFADYATF.
    OrthoDBiEOG7MH0XV.
    TreeFamiTF314803.

    Family and domain databases

    Gene3Di3.20.20.80. 4 hits.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 4 hits.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 4 hits.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9CMC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPWTALFL STVLLGLSCQ GSDWESDRNF ISAAGPLTND LVLNLNYPPG     50
    KQGSDVVSGN TDIYICQQPL PSFLSQYFSS LRASQVTHYK VLLSWAQLLP 100
    TGSSKNPDQE AVQCYRQLLQ SLKDAQLEPM VVLCHQTPPT SSAIQREGAF 150
    ADLFADYATL AFQSFGDLVE IWFTFSDLEK VIMDLPHKDL KASALQTLSN 200
    AHRRAFDIYH RKFSSQGGKL SVVLKAEDIP ELLPDPALAA LVQGSVDFLS 250
    LDLSYECQSV ATLPQKLSEL QNLEPKVKVF IYTLKLEDCP ATGTSPSSLL 300
    ISLLEAINKD QIQTVGFDVN AFLSCTSNSE ESPSCSLTDS LALQTEQQQE 350
    TAVPSSPGSA YQRVWAAFAN QSREERDAFL QDVFPEGFLW GISTGAFNVE 400
    GGWAEGGRGP SIWDHYGNLN AAEGQATAKV ASDSYHKPAS DVALLRGIRA 450
    QVYKFSISWS RLFPTGQKST PNRQGVAYYN KLIDRLLDSH IEPMATLFHW 500
    DLPQALQEQG GWQNESVVEA FLDYAAFCFS TFGDRVKLWV TFHEPWVMSY 550
    AGYGTGQHAP AISDPGMASF KVAHLILKAH ARTWHLYDLH HRLQQQGRVG 600
    IVLNSDWAEP LDRKSPQDLA AAERFLHFML GWFAHPIFVD GDYPTTLRAQ 650
    IQHINQQCGH PLAQLPEFTE AEKRLLKGSA DFLGLSHYTS RLISKAGRQT 700
    CTSSYDNIGG FSQHVDPEWP QTASPWIRVV PWGIRRLLRF ASMEYTKGKL 750
    PIFLAGNGMP VGEEADLFDD SVRVNYFNLY INEVLKAVKE DLVDVRSYIV 800
    RSLIDGYEGP LGFSQRFGLY HVNFNDSSRP RTPRKSAYFF TSIIEKNGFS 850
    AKKVKRNPLP VRADFTSRAR VTDSLPSEVP SKAKIVWEKF SKQPRFERDL 900
    FYHGTFRDDF LWGVSSSAYQ IEGGWNADGK GPSIWDNFTH TPGNGVKDNA 950
    TGDVACDSYH QLDADLNILR TLKVKSYRFS ISWSRIFPTG RNSTINKQGV 1000
    DYYNRLIDSL VDNNIFPMVT LFHWDLPQAL QDIGGWENPS LIELFDSYAD 1050
    FCFKTFGDRV KFWMTFNEPW CHVVLGYSSG IFPPSVQEPG WLPYKVSHIV 1100
    IKAHARVYHT YDEKYRSEQK GVISLSLNTH WAEPKDPGLQ RDVEAADRML 1150
    QFTMGWFAHP IFKNGDYPDV MKWTVGNRSE LQHLASSRLP TFTEEEKNYV 1200
    RGTADVFCIN TYTSVFVQHS TPRLNPPSYD DDMELKLIEM NSSTGVMHPD 1250
    VPWGTRRLLN WIKEEYGNIP IYITENGQGL ENPTLDDTER IFYHKTYINE 1300
    ALKAYKLDGV DLRGYSAWTL MDDFEWLLGY TMRFGLYHVD FNHVSRPRTA 1350
    RASARYYAEV IANNGMPLAR EDEFLYGEFP KGFIWSAASA SYQVEGAWRA 1400
    DGKGLSIWDT FSHTPLRIGN DDNGDVACDS YHKIAEDVVA LQNLGVSHYR 1450
    FSIAWSRILP DGTTKFINEA GLSYYVRFID ALLAAGITPQ VTIYHWDLPQ 1500
    ALQDVGGWEN ETIVQRFKEY ADVLFQRLGD RVKFWITLNE PFVIAAQGYG 1550
    TGVSAPGISF RPGTAPYIAG HNLIKAHAEA WHLYNDVYRA RQGGTISITI 1600
    SSDWAEPRDP TNQGDVEAAR RYVQFMGGWF AHPIFKNGDY PEVMKTRIRD 1650
    RSLAAGLNKS RLPEFTESEK SRIKGTFDFF GFNHYTTVLA YNLDYPAAFS 1700
    SFDADRGVAS IADSSWPVSG SFWLKVTPFG FRRILNWLKE EYNNPPIYVT 1750
    ENGVSRRGEP ELNDTDRIYY LRSYINEALK AVQDKVDLRG YTVWSIMDNF 1800
    EWATGFAERF GVHFVNRSDP SLPRIPKASA KFYATIVRCN GFPDPAQGPH 1850
    PCLQQPEDAA PTASPVQSEV PFLGLMLGIA EAQTALYVLF ALLLLGACSL 1900
    AFLTYKYCRR SKQGNAQPSQ HQLSPISSF 1929
    Length:1,929
    Mass (Da):217,609
    Last modified:February 5, 2008 - v1
    Checksum:i61735EC3BF194880
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06074532 Genomic DNA. No translation available.
    AABR06074533 Genomic DNA. No translation available.
    AABR06074534 Genomic DNA. No translation available.
    AB294578 Genomic DNA. Translation: BAF94253.1.
    RefSeqiNP_446293.1. NM_053841.1.
    UniGeneiRn.92376.

    Genome annotation databases

    EnsembliENSRNOT00000004908; ENSRNOP00000004908; ENSRNOG00000003681.
    GeneIDi116569.
    KEGGirno:116569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06074532 Genomic DNA. No translation available.
    AABR06074533 Genomic DNA. No translation available.
    AABR06074534 Genomic DNA. No translation available.
    AB294578 Genomic DNA. Translation: BAF94253.1 .
    RefSeqi NP_446293.1. NM_053841.1.
    UniGenei Rn.92376.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004908 ; ENSRNOP00000004908 ; ENSRNOG00000003681 .
    GeneIDi 116569.
    KEGGi rno:116569.

    Organism-specific databases

    CTDi 3938.
    RGDi 620823. Lct.

    Phylogenomic databases

    GeneTreei ENSGT00550000074452.
    HOVERGENi HBG006290.
    KOi K01229.
    OMAi FADYATF.
    OrthoDBi EOG7MH0XV.
    TreeFami TF314803.

    Miscellaneous databases

    NextBioi 619255.
    PROi A9CMC8.

    Gene expression databases

    Genevestigatori A9CMC8.

    Family and domain databases

    Gene3Di 3.20.20.80. 4 hits.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 4 hits.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 4 hits.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BUF/MnaImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiA9CMC8_RAT
    AccessioniPrimary (citable) accession number: A9CMC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3