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A9CMC8

- A9CMC8_RAT

UniProt

A9CMC8 - A9CMC8_RAT

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Protein
Submitted name:

Lactase-phlorizin hydrolase

Gene
Lct
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Names & Taxonomyi

Protein namesi
Submitted name:
Lactase-phlorizin hydrolaseImported
Submitted name:
Lct proteinImported
Gene namesi
Name:LctImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi620823. Lct.

Expressioni

Gene expression databases

GenevestigatoriA9CMC8.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074452.
HOVERGENiHBG006290.
KOiK01229.
OMAiFADYATF.
OrthoDBiEOG7MH0XV.
TreeFamiTF314803.

Family and domain databases

Gene3Di3.20.20.80. 4 hits.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 4 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 4 hits.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9CMC8-1 [UniParc]FASTAAdd to Basket

« Hide

MELPWTALFL STVLLGLSCQ GSDWESDRNF ISAAGPLTND LVLNLNYPPG     50
KQGSDVVSGN TDIYICQQPL PSFLSQYFSS LRASQVTHYK VLLSWAQLLP 100
TGSSKNPDQE AVQCYRQLLQ SLKDAQLEPM VVLCHQTPPT SSAIQREGAF 150
ADLFADYATL AFQSFGDLVE IWFTFSDLEK VIMDLPHKDL KASALQTLSN 200
AHRRAFDIYH RKFSSQGGKL SVVLKAEDIP ELLPDPALAA LVQGSVDFLS 250
LDLSYECQSV ATLPQKLSEL QNLEPKVKVF IYTLKLEDCP ATGTSPSSLL 300
ISLLEAINKD QIQTVGFDVN AFLSCTSNSE ESPSCSLTDS LALQTEQQQE 350
TAVPSSPGSA YQRVWAAFAN QSREERDAFL QDVFPEGFLW GISTGAFNVE 400
GGWAEGGRGP SIWDHYGNLN AAEGQATAKV ASDSYHKPAS DVALLRGIRA 450
QVYKFSISWS RLFPTGQKST PNRQGVAYYN KLIDRLLDSH IEPMATLFHW 500
DLPQALQEQG GWQNESVVEA FLDYAAFCFS TFGDRVKLWV TFHEPWVMSY 550
AGYGTGQHAP AISDPGMASF KVAHLILKAH ARTWHLYDLH HRLQQQGRVG 600
IVLNSDWAEP LDRKSPQDLA AAERFLHFML GWFAHPIFVD GDYPTTLRAQ 650
IQHINQQCGH PLAQLPEFTE AEKRLLKGSA DFLGLSHYTS RLISKAGRQT 700
CTSSYDNIGG FSQHVDPEWP QTASPWIRVV PWGIRRLLRF ASMEYTKGKL 750
PIFLAGNGMP VGEEADLFDD SVRVNYFNLY INEVLKAVKE DLVDVRSYIV 800
RSLIDGYEGP LGFSQRFGLY HVNFNDSSRP RTPRKSAYFF TSIIEKNGFS 850
AKKVKRNPLP VRADFTSRAR VTDSLPSEVP SKAKIVWEKF SKQPRFERDL 900
FYHGTFRDDF LWGVSSSAYQ IEGGWNADGK GPSIWDNFTH TPGNGVKDNA 950
TGDVACDSYH QLDADLNILR TLKVKSYRFS ISWSRIFPTG RNSTINKQGV 1000
DYYNRLIDSL VDNNIFPMVT LFHWDLPQAL QDIGGWENPS LIELFDSYAD 1050
FCFKTFGDRV KFWMTFNEPW CHVVLGYSSG IFPPSVQEPG WLPYKVSHIV 1100
IKAHARVYHT YDEKYRSEQK GVISLSLNTH WAEPKDPGLQ RDVEAADRML 1150
QFTMGWFAHP IFKNGDYPDV MKWTVGNRSE LQHLASSRLP TFTEEEKNYV 1200
RGTADVFCIN TYTSVFVQHS TPRLNPPSYD DDMELKLIEM NSSTGVMHPD 1250
VPWGTRRLLN WIKEEYGNIP IYITENGQGL ENPTLDDTER IFYHKTYINE 1300
ALKAYKLDGV DLRGYSAWTL MDDFEWLLGY TMRFGLYHVD FNHVSRPRTA 1350
RASARYYAEV IANNGMPLAR EDEFLYGEFP KGFIWSAASA SYQVEGAWRA 1400
DGKGLSIWDT FSHTPLRIGN DDNGDVACDS YHKIAEDVVA LQNLGVSHYR 1450
FSIAWSRILP DGTTKFINEA GLSYYVRFID ALLAAGITPQ VTIYHWDLPQ 1500
ALQDVGGWEN ETIVQRFKEY ADVLFQRLGD RVKFWITLNE PFVIAAQGYG 1550
TGVSAPGISF RPGTAPYIAG HNLIKAHAEA WHLYNDVYRA RQGGTISITI 1600
SSDWAEPRDP TNQGDVEAAR RYVQFMGGWF AHPIFKNGDY PEVMKTRIRD 1650
RSLAAGLNKS RLPEFTESEK SRIKGTFDFF GFNHYTTVLA YNLDYPAAFS 1700
SFDADRGVAS IADSSWPVSG SFWLKVTPFG FRRILNWLKE EYNNPPIYVT 1750
ENGVSRRGEP ELNDTDRIYY LRSYINEALK AVQDKVDLRG YTVWSIMDNF 1800
EWATGFAERF GVHFVNRSDP SLPRIPKASA KFYATIVRCN GFPDPAQGPH 1850
PCLQQPEDAA PTASPVQSEV PFLGLMLGIA EAQTALYVLF ALLLLGACSL 1900
AFLTYKYCRR SKQGNAQPSQ HQLSPISSF 1929
Length:1,929
Mass (Da):217,609
Last modified:February 5, 2008 - v1
Checksum:i61735EC3BF194880
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06074532 Genomic DNA. No translation available.
AABR06074533 Genomic DNA. No translation available.
AABR06074534 Genomic DNA. No translation available.
AB294578 Genomic DNA. Translation: BAF94253.1.
RefSeqiNP_446293.1. NM_053841.1.
UniGeneiRn.92376.

Genome annotation databases

EnsembliENSRNOT00000004908; ENSRNOP00000004908; ENSRNOG00000003681.
GeneIDi116569.
KEGGirno:116569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06074532 Genomic DNA. No translation available.
AABR06074533 Genomic DNA. No translation available.
AABR06074534 Genomic DNA. No translation available.
AB294578 Genomic DNA. Translation: BAF94253.1 .
RefSeqi NP_446293.1. NM_053841.1.
UniGenei Rn.92376.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004908 ; ENSRNOP00000004908 ; ENSRNOG00000003681 .
GeneIDi 116569.
KEGGi rno:116569.

Organism-specific databases

CTDi 3938.
RGDi 620823. Lct.

Phylogenomic databases

GeneTreei ENSGT00550000074452.
HOVERGENi HBG006290.
KOi K01229.
OMAi FADYATF.
OrthoDBi EOG7MH0XV.
TreeFami TF314803.

Miscellaneous databases

NextBioi 619255.
PROi A9CMC8.

Gene expression databases

Genevestigatori A9CMC8.

Family and domain databases

Gene3Di 3.20.20.80. 4 hits.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 4 hits.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 4 hits.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BUF/MnaImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA9CMC8_RAT
AccessioniPrimary (citable) accession number: A9CMC8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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