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A9CMC8

- A9CMC8_RAT

UniProt

A9CMC8 - A9CMC8_RAT

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Protein
Submitted name:

Lactase-phlorizin hydrolase

Gene

Lct

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Names & Taxonomyi

Protein namesi
Submitted name:
Lactase-phlorizin hydrolaseImported
Submitted name:
Lct proteinImported
Gene namesi
Name:LctImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi620823. Lct.

Expressioni

Gene expression databases

GenevestigatoriA9CMC8.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074452.
HOVERGENiHBG006290.
KOiK01229.
OMAiFADYATF.
OrthoDBiEOG7MH0XV.
TreeFamiTF314803.

Family and domain databases

Gene3Di3.20.20.80. 4 hits.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 4 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 4 hits.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9CMC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPWTALFL STVLLGLSCQ GSDWESDRNF ISAAGPLTND LVLNLNYPPG
60 70 80 90 100
KQGSDVVSGN TDIYICQQPL PSFLSQYFSS LRASQVTHYK VLLSWAQLLP
110 120 130 140 150
TGSSKNPDQE AVQCYRQLLQ SLKDAQLEPM VVLCHQTPPT SSAIQREGAF
160 170 180 190 200
ADLFADYATL AFQSFGDLVE IWFTFSDLEK VIMDLPHKDL KASALQTLSN
210 220 230 240 250
AHRRAFDIYH RKFSSQGGKL SVVLKAEDIP ELLPDPALAA LVQGSVDFLS
260 270 280 290 300
LDLSYECQSV ATLPQKLSEL QNLEPKVKVF IYTLKLEDCP ATGTSPSSLL
310 320 330 340 350
ISLLEAINKD QIQTVGFDVN AFLSCTSNSE ESPSCSLTDS LALQTEQQQE
360 370 380 390 400
TAVPSSPGSA YQRVWAAFAN QSREERDAFL QDVFPEGFLW GISTGAFNVE
410 420 430 440 450
GGWAEGGRGP SIWDHYGNLN AAEGQATAKV ASDSYHKPAS DVALLRGIRA
460 470 480 490 500
QVYKFSISWS RLFPTGQKST PNRQGVAYYN KLIDRLLDSH IEPMATLFHW
510 520 530 540 550
DLPQALQEQG GWQNESVVEA FLDYAAFCFS TFGDRVKLWV TFHEPWVMSY
560 570 580 590 600
AGYGTGQHAP AISDPGMASF KVAHLILKAH ARTWHLYDLH HRLQQQGRVG
610 620 630 640 650
IVLNSDWAEP LDRKSPQDLA AAERFLHFML GWFAHPIFVD GDYPTTLRAQ
660 670 680 690 700
IQHINQQCGH PLAQLPEFTE AEKRLLKGSA DFLGLSHYTS RLISKAGRQT
710 720 730 740 750
CTSSYDNIGG FSQHVDPEWP QTASPWIRVV PWGIRRLLRF ASMEYTKGKL
760 770 780 790 800
PIFLAGNGMP VGEEADLFDD SVRVNYFNLY INEVLKAVKE DLVDVRSYIV
810 820 830 840 850
RSLIDGYEGP LGFSQRFGLY HVNFNDSSRP RTPRKSAYFF TSIIEKNGFS
860 870 880 890 900
AKKVKRNPLP VRADFTSRAR VTDSLPSEVP SKAKIVWEKF SKQPRFERDL
910 920 930 940 950
FYHGTFRDDF LWGVSSSAYQ IEGGWNADGK GPSIWDNFTH TPGNGVKDNA
960 970 980 990 1000
TGDVACDSYH QLDADLNILR TLKVKSYRFS ISWSRIFPTG RNSTINKQGV
1010 1020 1030 1040 1050
DYYNRLIDSL VDNNIFPMVT LFHWDLPQAL QDIGGWENPS LIELFDSYAD
1060 1070 1080 1090 1100
FCFKTFGDRV KFWMTFNEPW CHVVLGYSSG IFPPSVQEPG WLPYKVSHIV
1110 1120 1130 1140 1150
IKAHARVYHT YDEKYRSEQK GVISLSLNTH WAEPKDPGLQ RDVEAADRML
1160 1170 1180 1190 1200
QFTMGWFAHP IFKNGDYPDV MKWTVGNRSE LQHLASSRLP TFTEEEKNYV
1210 1220 1230 1240 1250
RGTADVFCIN TYTSVFVQHS TPRLNPPSYD DDMELKLIEM NSSTGVMHPD
1260 1270 1280 1290 1300
VPWGTRRLLN WIKEEYGNIP IYITENGQGL ENPTLDDTER IFYHKTYINE
1310 1320 1330 1340 1350
ALKAYKLDGV DLRGYSAWTL MDDFEWLLGY TMRFGLYHVD FNHVSRPRTA
1360 1370 1380 1390 1400
RASARYYAEV IANNGMPLAR EDEFLYGEFP KGFIWSAASA SYQVEGAWRA
1410 1420 1430 1440 1450
DGKGLSIWDT FSHTPLRIGN DDNGDVACDS YHKIAEDVVA LQNLGVSHYR
1460 1470 1480 1490 1500
FSIAWSRILP DGTTKFINEA GLSYYVRFID ALLAAGITPQ VTIYHWDLPQ
1510 1520 1530 1540 1550
ALQDVGGWEN ETIVQRFKEY ADVLFQRLGD RVKFWITLNE PFVIAAQGYG
1560 1570 1580 1590 1600
TGVSAPGISF RPGTAPYIAG HNLIKAHAEA WHLYNDVYRA RQGGTISITI
1610 1620 1630 1640 1650
SSDWAEPRDP TNQGDVEAAR RYVQFMGGWF AHPIFKNGDY PEVMKTRIRD
1660 1670 1680 1690 1700
RSLAAGLNKS RLPEFTESEK SRIKGTFDFF GFNHYTTVLA YNLDYPAAFS
1710 1720 1730 1740 1750
SFDADRGVAS IADSSWPVSG SFWLKVTPFG FRRILNWLKE EYNNPPIYVT
1760 1770 1780 1790 1800
ENGVSRRGEP ELNDTDRIYY LRSYINEALK AVQDKVDLRG YTVWSIMDNF
1810 1820 1830 1840 1850
EWATGFAERF GVHFVNRSDP SLPRIPKASA KFYATIVRCN GFPDPAQGPH
1860 1870 1880 1890 1900
PCLQQPEDAA PTASPVQSEV PFLGLMLGIA EAQTALYVLF ALLLLGACSL
1910 1920
AFLTYKYCRR SKQGNAQPSQ HQLSPISSF
Length:1,929
Mass (Da):217,609
Last modified:February 5, 2008 - v1
Checksum:i61735EC3BF194880
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06074532 Genomic DNA. No translation available.
AABR06074533 Genomic DNA. No translation available.
AABR06074534 Genomic DNA. No translation available.
AB294578 Genomic DNA. Translation: BAF94253.1.
RefSeqiNP_446293.1. NM_053841.1.
UniGeneiRn.92376.

Genome annotation databases

EnsembliENSRNOT00000004908; ENSRNOP00000004908; ENSRNOG00000003681.
GeneIDi116569.
KEGGirno:116569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06074532 Genomic DNA. No translation available.
AABR06074533 Genomic DNA. No translation available.
AABR06074534 Genomic DNA. No translation available.
AB294578 Genomic DNA. Translation: BAF94253.1 .
RefSeqi NP_446293.1. NM_053841.1.
UniGenei Rn.92376.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004908 ; ENSRNOP00000004908 ; ENSRNOG00000003681 .
GeneIDi 116569.
KEGGi rno:116569.

Organism-specific databases

CTDi 3938.
RGDi 620823. Lct.

Phylogenomic databases

GeneTreei ENSGT00550000074452.
HOVERGENi HBG006290.
KOi K01229.
OMAi FADYATF.
OrthoDBi EOG7MH0XV.
TreeFami TF314803.

Miscellaneous databases

NextBioi 619255.
PROi A9CMC8.

Gene expression databases

Genevestigatori A9CMC8.

Family and domain databases

Gene3Di 3.20.20.80. 4 hits.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 4 hits.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 4 hits.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BUF/MnaImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA9CMC8_RAT
AccessioniPrimary (citable) accession number: A9CMC8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3