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Protein

Transmembrane protein 163

Gene

Tmem163

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.1 Publication

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

Keywordsi

LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 163
Alternative name(s):
Synaptic vesicle membrane protein of 31 kDa
Gene namesi
Name:Tmem163
Synonyms:Sv31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306212. Tmem163.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 115ExtracellularSequence analysis7
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 149CytoplasmicSequence analysisAdd BLAST13
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 186ExtracellularSequence analysisAdd BLAST16
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 216CytoplasmicSequence analysis9
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 254ExtracellularSequence analysisAdd BLAST17
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 288CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • early endosome membrane Source: UniProtKB
  • integral component of synaptic vesicle membrane Source: UniProtKB

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004165861 – 288Transmembrane protein 163Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA9CMA6.
PRIDEiA9CMA6.

PTM databases

iPTMnetiA9CMA6.
PhosphoSitePlusiA9CMA6.

Expressioni

Tissue specificityi

Strongly expressed in brain. Also detected in lung, liver, kidney and spleen. Mainly expressed in the glutaminergic neuron subpopulations.2 Publications

Gene expression databases

BgeeiENSRNOG00000003769.
GenevisibleiA9CMA6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005006.

Structurei

3D structure databases

ProteinModelPortaliA9CMA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9N. Eukaryota.
ENOG410Z7QG. LUCA.
GeneTreeiENSGT00390000001170.
HOGENOMiHOG000294211.
HOVERGENiHBG094063.
InParanoidiA9CMA6.
OMAiFKHNSAV.
OrthoDBiEOG091G0JXN.
PhylomeDBiA9CMA6.
TreeFamiTF330782.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiView protein in InterPro
IPR027469. Cation_efflux_TMD.
IPR026765. Tmem163.
PANTHERiPTHR31937. PTHR31937. 1 hit.

Sequencei

Sequence statusi: Complete.

A9CMA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAPGSERR SPPGPGVPRP PPRGHAPSTA APAPNPAPLS SSMQPDEERQ
60 70 80 90 100
PRISESGQFS DGFEDRGLLE SSTRLKPHEA QNYRKKALWV SWLSIIVTLA
110 120 130 140 150
LAVAAFTVSV MRYSASAFGF AFDAILDVLS SAIVLWRYSN AAAVHSAHRE
160 170 180 190 200
YIACVILGVI FLLSSICIVV KAIHDLSTRL LPEVDDFLFS VSILSGILCS
210 220 230 240 250
VLAVLKFMLG KVLTSRALIT DGFNSLVGGV MGFSILLSAE VFKHNAAVWY
260 270 280
LDGSIGVLIG LTIFAYGVKL LIDMVPRVRQ TRHYEMFE
Length:288
Mass (Da):31,344
Last modified:February 5, 2008 - v1
Checksum:i5C0577453233F89D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB294577 Genomic DNA. Translation: BAF94224.1.
AB294578 Genomic DNA. Translation: BAF94244.1.
RefSeqiNP_001104233.2. NM_001110763.2.
UniGeneiRn.25191.

Genome annotation databases

EnsembliENSRNOT00000005006; ENSRNOP00000005006; ENSRNOG00000003769.
GeneIDi360839.
KEGGirno:360839.
UCSCiRGD:1306212. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB294577 Genomic DNA. Translation: BAF94224.1.
AB294578 Genomic DNA. Translation: BAF94244.1.
RefSeqiNP_001104233.2. NM_001110763.2.
UniGeneiRn.25191.

3D structure databases

ProteinModelPortaliA9CMA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005006.

PTM databases

iPTMnetiA9CMA6.
PhosphoSitePlusiA9CMA6.

Proteomic databases

PaxDbiA9CMA6.
PRIDEiA9CMA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005006; ENSRNOP00000005006; ENSRNOG00000003769.
GeneIDi360839.
KEGGirno:360839.
UCSCiRGD:1306212. rat.

Organism-specific databases

CTDi81615.
RGDi1306212. Tmem163.

Phylogenomic databases

eggNOGiENOG410IE9N. Eukaryota.
ENOG410Z7QG. LUCA.
GeneTreeiENSGT00390000001170.
HOGENOMiHOG000294211.
HOVERGENiHBG094063.
InParanoidiA9CMA6.
OMAiFKHNSAV.
OrthoDBiEOG091G0JXN.
PhylomeDBiA9CMA6.
TreeFamiTF330782.

Miscellaneous databases

PROiPR:A9CMA6.

Gene expression databases

BgeeiENSRNOG00000003769.
GenevisibleiA9CMA6. RN.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiView protein in InterPro
IPR027469. Cation_efflux_TMD.
IPR026765. Tmem163.
PANTHERiPTHR31937. PTHR31937. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM163_RAT
AccessioniPrimary (citable) accession number: A9CMA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: February 5, 2008
Last modified: March 15, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.