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A9CII8

- A9CII8_AGRT5

UniProt

A9CII8 - A9CII8_AGRT5

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icdA, Atu1870
Organism
Agrobacterium tumefaciens (strain C58 / ATCC 33970)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarity
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:Atu1870Imported
OrganismiAgrobacterium tumefaciens (strain C58 / ATCC 33970)Imported
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000000813: Chromosome circular

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu1870.

Structurei

3D structure databases

ProteinModelPortaliA9CII8.
SMRiA9CII8. Positions 3-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiTRIIWDK.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9CII8-1 [UniParc]FASTAAdd to Basket

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MAKIKVANPV VDLDGDEMTR IIWQLIKDKL ILPYLDLDIE YYDLSVENRD    50
ATNDQVTVDA AHAIKKHGVG IKCATITPDE QRVEEFGLKQ MWKSPNGTIR 100
NILGGVIFRE PIICKNVPRL VPGWTKPIVV GRHAFGDQYK ATDFKFPGKG 150
KLTIKFVGED GTVIEKDVFD APSAGVALAM YNLDESIREF ARASMMYGLM 200
RKWPVYLSTK NTILKAYDGR FKDIFEEVYQ TEFKAKFDEV GITYEHRLID 250
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLSPDGRT 300
VEAEAAHGTV TRHYRQHQKG QETSTNSIAS IFAWTRGLAH RAKLDDNAEL 350
AKFATTLETV CVDTVESGFM TKDLALLIGP DQPWLSTTAF LDKIDENLKT 400
AMAA 404
Length:404
Mass (Da):45,068
Last modified:January 15, 2008 - v1
Checksum:iB472E27150AF00FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK87636.2.
RefSeqiNP_354851.2. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87636; AAK87636; Atu1870.
GeneIDi1133908.
KEGGiatu:Atu1870.
PATRICi20813519. VBIAgrTum91616_1884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007869 Genomic DNA. Translation: AAK87636.2 .
RefSeqi NP_354851.2. NC_003062.2.

3D structure databases

ProteinModelPortali A9CII8.
SMRi A9CII8. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176299.Atu1870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK87636 ; AAK87636 ; Atu1870 .
GeneIDi 1133908.
KEGGi atu:Atu1870.
PATRICi 20813519. VBIAgrTum91616_1884.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi TRIIWDK.
OrthoDBi EOG628F3X.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiA9CII8_AGRT5
AccessioniPrimary (citable) accession number: A9CII8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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