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A9CII8 (A9CII8_AGRT5) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A9CII8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: B472E27150AF00FD

FASTA40445,068
        10         20         30         40         50         60 
MAKIKVANPV VDLDGDEMTR IIWQLIKDKL ILPYLDLDIE YYDLSVENRD ATNDQVTVDA 

        70         80         90        100        110        120 
AHAIKKHGVG IKCATITPDE QRVEEFGLKQ MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTKPIVV GRHAFGDQYK ATDFKFPGKG KLTIKFVGED GTVIEKDVFD APSAGVALAM 

       190        200        210        220        230        240 
YNLDESIREF ARASMMYGLM RKWPVYLSTK NTILKAYDGR FKDIFEEVYQ TEFKAKFDEV 

       250        260        270        280        290        300 
GITYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLSPDGRT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQKG QETSTNSIAS IFAWTRGLAH RAKLDDNAEL AKFATTLETV 

       370        380        390        400 
CVDTVESGFM TKDLALLIGP DQPWLSTTAF LDKIDENLKT AMAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007869 Genomic DNA. Translation: AAK87636.2.
RefSeqNP_354851.2. NC_003062.2.

3D structure databases

ProteinModelPortalA9CII8.
SMRA9CII8. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176299.Atu1870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK87636; AAK87636; Atu1870.
GeneID1133908.
KEGGatu:Atu1870.
PATRIC20813519. VBIAgrTum91616_1884.

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9CII8_AGRT5
AccessionPrimary (citable) accession number: A9CII8
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)