A9CB27 (ZPR1_PAPAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein ZPR1

Alternative name(s):
Zinc finger protein 259

Gene names

Name:	ZNF259
Synonyms:	ZPR1

Organism

Papio anubis (Olive baboon)

Taxonomic identifier

9555 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus By similarity.
Subunit structure	Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus › nucleolus By similarity. Note: Translocates to the nucleolus after treatment with mitogens By similarity.
Sequence similarities	Belongs to the ZPR1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Zinc finger protein ZPR1		PRO_0000328435
Regions
	Zinc finger	51 – 83	33	C4-type 1
	Zinc finger	259 – 291	33	C4-type 2

Sequences

	Sequence		Length	Mass (Da)
	A9CB27 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 9A742761D1F96A22	FASTA	459	51,067
	10 20 30 40 50 60 MAASGAVEPG PPGAAVAPSP ALAPPPAPDH LFRPISAEDE EQQPTEIESL CMNCYCNGMT 70 80 90 100 110 120 RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRVQDQG VRYTLTVRAP EDMNREVVKT 130 140 150 160 170 180 DSATTRIPEL DFEIPAFSQK GALTTVEGLI TRAISGLEQD QPARRANKDA TAERIDEFIV 190 200 210 220 230 240 KLKELKQVAS PFTLIIDDPS GNSFVENPHA PQKDDSLVIT HYNRTQHQKE MLGLQEEAPA 250 260 270 280 290 300 EKPEEEDLRN EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS 310 320 330 340 350 360 GGAVEPLGTR ITLHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK FTTLEGLLKD 370 380 390 400 410 420 IRELVTKNPF TLGDSSNPCQ KERLQEFSQK MDQIIEGNMK AHFIMDDPAG NSYLQNVYAP 430 440 450 EDDPEMKVER YKRTFDQNEE LGLNDMKTEG YEAGLASQR

References

[1]

"NISC comparative sequencing initiative." Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C., Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N. , Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K., Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DP000486 Genomic DNA. Translation: ABW96811.1.
RefSeq	NP_001162238.1. NM_001168767.1.
UniGene	Pan.8036.
3D structure databases
ProteinModelPortal	A9CB27.
SMR	A9CB27. Positions 47-440.
ModBase	Search...
Proteomic databases
PRIDE	A9CB27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100137229.
Organism-specific databases
CTD	8882.
Phylogenomic databases
HOVERGEN	HBG002608.
Family and domain databases
InterPro	IPR004457. Znf_ZPR1. [Graphical view]
Pfam	PF03367. zf-ZPR1. 2 hits. [Graphical view]
SMART	SM00709. Zpr1. 2 hits. [Graphical view]
TIGRFAMs	TIGR00310. ZPR1_znf. 2 hits.
ProtoNet	Search...

Entry information

Entry name

ZPR1_PAPAN

Accession

Primary (citable) accession number: A9CB27

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	January 15, 2008
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program