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A9C1G8

- SYL_DELAS

UniProt

A9C1G8 - SYL_DELAS

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Protein

Leucine--tRNA ligase

Gene
leuS, Daci_6003
Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei662 – 6621ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDACI398578:GHK3-6097-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Daci_6003
OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
Taxonomic identifieri398578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
ProteomesiUP000000784: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911Leucine--tRNA ligaseUniRule annotationPRO_1000091312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398578.Daci_6003.

Structurei

3D structure databases

ProteinModelPortaliA9C1G8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi659 – 6635"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9C1G8-1 [UniParc]FASTAAdd to Basket

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MQEKYNHIDV ERAAQDHWSA RDAYRVTEDQ AKPKFYACSM LPYPSGKLHM    50
GHVRNYTIND MLTRQLRMKG YNVLMPMGWD AFGLPAENAA LKNKVPPAQW 100
TYDNIAYMKK QMQAMGLAID WSREIATCDP DYYKWNQWLF LKMLEKGIAY 150
RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG APVEKREIPG YYLKITDYAQ 200
ELLDHVQVGG DKATLTGWPE KVRLMQENWI GKSSGVRFAF THDIRGADGQ 250
PIQDGRLYVF TTRADTIMGV TFCAVAPEHP LALHAAATSP KLAAFIEECK 300
KGGTTEAELA VKEKEGLPTG LFVTHPLTGA QVEVWVGNYV LMSYGDGAVM 350
GVPAHDERDF AFAKKYGIAI RQVIAVEGET FSTEAWADWY GDKQRAVCIE 400
SGELDGLPHA AAVDKVAELL AAKGLGEKKT TWRLRDWGVS RQRYWGTPIP 450
IIHCEDCGAQ PVPAKDLPVV LPQDLVPDGS GNPLIKSEAF HAGVVCPCCG 500
KSARRETDTM DTFVDSSWYF MRYCDARNSE QMVAEGAEYW MRDQNAATGG 550
SGMDQYIGGI EHAILHLLYA RFWTKVMRDL GLVKVDEPFT KLLTQGMVLN 600
HIYSRRTAKG AKEYFWPKDV EHVFDETGKI VGAKLKAEVD SADGLLPVGT 650
DIDYEGVGTM SKSKNNGIDP QELIEKYGAD TARLYTMFTA PPELTLEWND 700
AAVEGSYRFL RRVYNFGAKL SQMDMAGAVQ SVAGAKSLDD VEFGKAAKSL 750
RLEIHTVLKQ VEYDYQRMQY NTVVSGAMKM INALEDFKSF DDAGAQVALI 800
EGFGILLRVL YPATPHLAHA LWSELGYAAH LGDVLDAPWP QVDPQALVQD 850
EISLVLQVNG KLRGAILVSS TADKAEIERI ALANEECQKF TNGAVPKKVI 900
VVPGRLVNVV V 911
Length:911
Mass (Da):101,345
Last modified:January 15, 2008 - v1
Checksum:iBBEBCBD4F02DA4FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000884 Genomic DNA. Translation: ABX38631.1.
RefSeqiYP_001567016.1. NC_010002.1.

Genome annotation databases

EnsemblBacteriaiABX38631; ABX38631; Daci_6003.
GeneIDi5751634.
KEGGidac:Daci_6003.
PATRICi21646121. VBIDelAci41351_6075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000884 Genomic DNA. Translation: ABX38631.1 .
RefSeqi YP_001567016.1. NC_010002.1.

3D structure databases

ProteinModelPortali A9C1G8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 398578.Daci_6003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX38631 ; ABX38631 ; Daci_6003 .
GeneIDi 5751634.
KEGGi dac:Daci_6003.
PATRICi 21646121. VBIDelAci41351_6075.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DACI398578:GHK3-6097-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Delftia acidovorans DSM 14801 / SPH-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14801 / SPH-1.

Entry informationi

Entry nameiSYL_DELAS
AccessioniPrimary (citable) accession number: A9C1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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