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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei662ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDACI398578:G1GAI-6178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Daci_6003
OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
Taxonomic identifieri398578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
Proteomesi
  • UP000000784 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913121 – 911Leucine--tRNA ligaseAdd BLAST911

Proteomic databases

PRIDEiA9C1G8

Interactioni

Protein-protein interaction databases

STRINGi398578.Daci_6003

Structurei

3D structure databases

ProteinModelPortaliA9C1G8
SMRiA9C1G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi659 – 663"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9C1G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEKYNHIDV ERAAQDHWSA RDAYRVTEDQ AKPKFYACSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND MLTRQLRMKG YNVLMPMGWD AFGLPAENAA LKNKVPPAQW
110 120 130 140 150
TYDNIAYMKK QMQAMGLAID WSREIATCDP DYYKWNQWLF LKMLEKGIAY
160 170 180 190 200
RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG APVEKREIPG YYLKITDYAQ
210 220 230 240 250
ELLDHVQVGG DKATLTGWPE KVRLMQENWI GKSSGVRFAF THDIRGADGQ
260 270 280 290 300
PIQDGRLYVF TTRADTIMGV TFCAVAPEHP LALHAAATSP KLAAFIEECK
310 320 330 340 350
KGGTTEAELA VKEKEGLPTG LFVTHPLTGA QVEVWVGNYV LMSYGDGAVM
360 370 380 390 400
GVPAHDERDF AFAKKYGIAI RQVIAVEGET FSTEAWADWY GDKQRAVCIE
410 420 430 440 450
SGELDGLPHA AAVDKVAELL AAKGLGEKKT TWRLRDWGVS RQRYWGTPIP
460 470 480 490 500
IIHCEDCGAQ PVPAKDLPVV LPQDLVPDGS GNPLIKSEAF HAGVVCPCCG
510 520 530 540 550
KSARRETDTM DTFVDSSWYF MRYCDARNSE QMVAEGAEYW MRDQNAATGG
560 570 580 590 600
SGMDQYIGGI EHAILHLLYA RFWTKVMRDL GLVKVDEPFT KLLTQGMVLN
610 620 630 640 650
HIYSRRTAKG AKEYFWPKDV EHVFDETGKI VGAKLKAEVD SADGLLPVGT
660 670 680 690 700
DIDYEGVGTM SKSKNNGIDP QELIEKYGAD TARLYTMFTA PPELTLEWND
710 720 730 740 750
AAVEGSYRFL RRVYNFGAKL SQMDMAGAVQ SVAGAKSLDD VEFGKAAKSL
760 770 780 790 800
RLEIHTVLKQ VEYDYQRMQY NTVVSGAMKM INALEDFKSF DDAGAQVALI
810 820 830 840 850
EGFGILLRVL YPATPHLAHA LWSELGYAAH LGDVLDAPWP QVDPQALVQD
860 870 880 890 900
EISLVLQVNG KLRGAILVSS TADKAEIERI ALANEECQKF TNGAVPKKVI
910
VVPGRLVNVV V
Length:911
Mass (Da):101,345
Last modified:January 15, 2008 - v1
Checksum:iBBEBCBD4F02DA4FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000884 Genomic DNA Translation: ABX38631.1
RefSeqiWP_012207800.1, NC_010002.1

Genome annotation databases

EnsemblBacteriaiABX38631; ABX38631; Daci_6003
GeneIDi24114088
KEGGidac:Daci_6003

Similar proteinsi

Entry informationi

Entry nameiSYL_DELAS
AccessioniPrimary (citable) accession number: A9C1G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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