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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase I (Daci_5449), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciDACI398578:G1GAI-3748-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Daci_3650
OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
Taxonomic identifieri398578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003720261 – 296GTP cyclohydrolase FolE2Add BLAST296

Proteomic databases

PRIDEiA9C020

Interactioni

Protein-protein interaction databases

STRINGi398578.Daci_3650

Structurei

3D structure databases

ProteinModelPortaliA9C020
SMRiA9C020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OMAiPYSSTCP

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

A9C020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAPLPDVSL TDPAPSLSPL QWVGMQGIDL PVTVAEPGYW RELHARADVQ
60 70 80 90 100
VDLPAAHVKG IHMSRLYRQL DSLAEESALS ALALRHALQA MIDSHLDCQS
110 120 130 140 150
RSARMRLSLD LLAQRPALVT HDLSGWKSYP VRLDATLAQG VFQLRLQVGV
160 170 180 190 200
GYSSTCPCSA ALSRQLLEQG FLQAFAGEPL VEPDQVASWL RRHGTLATAH
210 220 230 240 250
SQRSEAQVSV DLACDAPDLG ILPLIARVEQ ALGTPVQTAV KRADEQAFAA
260 270 280 290
LNGRNLMFVE DAARRIQAAL EGIYARPRVH VRHMESLHPH DAVAWA
Length:296
Mass (Da):32,306
Last modified:January 15, 2008 - v1
Checksum:i978F17C3BFB5352F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000884 Genomic DNA Translation: ABX36282.1
RefSeqiWP_012205478.1, NC_010002.1

Genome annotation databases

EnsemblBacteriaiABX36282; ABX36282; Daci_3650
GeneIDi24119026
KEGGidac:Daci_3650

Similar proteinsi

Entry informationi

Entry nameiGCH4_DELAS
AccessioniPrimary (citable) accession number: A9C020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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