Reviewed, UniProtKB/Swiss-Prot A9BZG3 (IOLG_DELAS)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Daci_2925

Organism

Delftia acidovorans (strain DSM 14801 / SPH-1) [Complete proteome] [HAMAP]

Taxonomic identifier

398578 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Delftia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352568

Sequences

	Sequence		Length	Mass (Da)
	A9BZG3-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 0DDFF42E638AE308	FASTA	337	36,323
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHVRR MYQTLSGARV VAVTDIDAQQ VREVMARHGP DIEAFDSGPA 70 80 90 100 110 120 LIAAPQVQAV LVTSWGPTHE ELVLAAIAQG KPVFCEKPLA VTAAGCLRIV QAEMAHGQRL 130 140 150 160 170 180 VQVGFMRPYD AGYRALRQVI ASGQIGAPLM VHCAHRNPCV ADGYTTGMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLDDEYA SAQVVYPKRT RHALPHLADP QIVLLETVGG IRIDVEVFVN CRYGYDIQCE 250 260 270 280 290 300 VVGETGIARM PDPAAVPLKS AAMYSIPILT DWKQRFMAAY DVELQAFIDG VRGQRLTGPS 310 320 330 AWDAHAAAVA ADACVLAQSS GAVERMAAAP RPAFYQS

References

[1]

"Complete sequence of Delftia acidovorans DSM 14801 / SPH-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000884 Genomic DNA. Translation: ABX35563.1.
RefSeq	YP_001563948.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5748507.
GenomeReviews	Gene locus Daci_2925 in contig CP000884_GR.
KEGG	dac:Daci_2925.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_DELAS

Accession

Primary (citable) accession number: A9BZG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)