A9BZG3 (IOLG_DELAS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Daci_2925

Organism

Delftia acidovorans (strain DSM 14801 / SPH-1) [Complete proteome] [HAMAP]

Taxonomic identifier

398578 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Delftia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352568

Sequences

	Sequence		Length	Mass (Da)
	A9BZG3 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 0DDFF42E638AE308	FASTA	337	36,323
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHVRR MYQTLSGARV VAVTDIDAQQ VREVMARHGP DIEAFDSGPA 70 80 90 100 110 120 LIAAPQVQAV LVTSWGPTHE ELVLAAIAQG KPVFCEKPLA VTAAGCLRIV QAEMAHGQRL 130 140 150 160 170 180 VQVGFMRPYD AGYRALRQVI ASGQIGAPLM VHCAHRNPCV ADGYTTGMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLDDEYA SAQVVYPKRT RHALPHLADP QIVLLETVGG IRIDVEVFVN CRYGYDIQCE 250 260 270 280 290 300 VVGETGIARM PDPAAVPLKS AAMYSIPILT DWKQRFMAAY DVELQAFIDG VRGQRLTGPS 310 320 330 AWDAHAAAVA ADACVLAQSS GAVERMAAAP RPAFYQS

References

[1]

"Complete sequence of Delftia acidovorans DSM 14801 / SPH-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 14801 / SPH-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000884 Genomic DNA. Translation: ABX35563.1.
RefSeq	YP_001563948.1. NC_010002.1.
3D structure databases
ProteinModelPortal	A9BZG3.
ModBase	Search...
Protein-protein interaction databases
STRING	A9BZG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5748507.
GenomeReviews	Gene locus Daci_2925 in contig CP000884_GR.
KEGG	dac:Daci_2925.
PATRIC	21639813. VBIDelAci41351_2967.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK896889.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_DELAS

Accession

Primary (citable) accession number: A9BZG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program