Dihydroorotase - Delftia acidovorans (strain DSM 14801 / SPH-1)

Contribute

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot A9BSM4 (PYRC_DELAS)

Last modified November 3, 2009. Version 19. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3

Gene names

Name:	pyrC
Ordered Locus Names:	Daci_1385

Organism

Delftia acidovorans (strain DSM 14801 / SPH-1) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Delftia

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H₂O = N-carbamoyl-L-aspartate. HAMAP MF_00219
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

346

Dihydroorotase HAMAP MF_00219

PRO_1000100040

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1; via carbamate group By similarity

Metal binding

1

Zinc 2; via carbamate group By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 1 By similarity

Amino acid modifications

Modified residue

1

N6-carboxylysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A9BSM4-1 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 00052EA2F4B1DF32
Show »

346

38,233

        10         20         30         40         50         60 
MTASTNTLTI TRPDDWHLHV RDGEAMRSVV PHTAAQFARA IIMPNLKPPV TTAEQALEYK 

        70         80         90        100        110        120 
QRILSAVPEG MAFEPLMTLY LTDNLPPEEI VRAKAAGVVA CKLYPAGATT NSDHGVTDLR 

       130        140        150        160        170        180 
KIYPTLEAMQ REGLLLLVHG EVTSSDIDLF DREAAFIDQH LIPLRRDFPE LKIVFEHITT 

       190        200        210        220        230        240 
REAAQYVTEA DRFVGATITP QHLLFNRNAI FTGGIRPHYY CLPVLKRETH RLALVEAATS 

       250        260        270        280        290        300 
GLPKFFLGTD SAPHAAHLKE HATGCAGCYS AHAAIEMYAE AFDNAGALDK LEAFASFNGP 

       310        320        330        340 
DFYSLPRNTG KITLVRESWT PPDSFAFGEA QLKPLRSGEA LPWKLV

References

[1]

"Complete sequence of Delftia acidovorans DSM 14801 / SPH-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000884 Genomic DNA. Translation: ABX34029.1.
RefSeq	YP_001562414.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5746940.
GenomeReviews	Gene locus Daci_1385 in contig CP000884_GR.
KEGG	dac:Daci_1385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IMPNLVP.
Family and domain databases
HAMAP	MF_00219. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. pyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRC_DELAS

Accession

Primary (citable) accession number: A9BSM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents