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Protein

NAD kinase

Gene

nadK

Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80Proton acceptorUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei184NADUniRule annotation1
Binding sitei219NAD; via carbonyl oxygenUniRule annotation1
Binding sitei253NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 81NADUniRule annotation2
Nucleotide bindingi154 – 155NADUniRule annotation2
Nucleotide bindingi195 – 200NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Daci_5420
OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
Taxonomic identifieri398578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
Proteomesi
  • UP000000784 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208501 – 298NAD kinaseAdd BLAST298

Proteomic databases

PRIDEiA9BP04

Interactioni

Protein-protein interaction databases

STRINGi398578.Daci_5420

Structurei

3D structure databases

ProteinModelPortaliA9BP04
SMRiA9BP04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A9BP04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTFRHVAL IGKYHAPSAS APSENASNAL ERIADFLRRQ GCEVVLDTQS
60 70 80 90 100
ALHAGLTDYP TLDVDGLGRH CDLGLVVGGD GTMLGVSRHL AQYGTPLIGV
110 120 130 140 150
NQGRLGFVTD IALEDFEATL TPMLQGEYEE DLRPLMCARV IRDGQCVFEA
160 170 180 190 200
LAMNDVVVNR GGTSGMVELR IEVGGRFVSN QRADGLIVAT PTGSTAYALS
210 220 230 240 250
AGGPMMHPSI PAWVMAPIAP HNLSNRPIVL SDANEVTIEV VAGRDVSANF
260 270 280 290
DMQSLASLQH GDRILVSRAH HSVRFLHPKG WNYFATLRKK LGWNEGGA
Length:298
Mass (Da):32,012
Last modified:January 15, 2008 - v1
Checksum:iD9CFB822B1660E19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000884 Genomic DNA Translation: ABX38049.1
RefSeqiWP_012207218.1, NC_010002.1

Genome annotation databases

EnsemblBacteriaiABX38049; ABX38049; Daci_5420
GeneIDi24114752
KEGGidac:Daci_5420

Similar proteinsi

Entry informationi

Entry nameiNADK_DELAS
AccessioniPrimary (citable) accession number: A9BP04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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