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A9BP04

- NADK_DELAS

UniProt

A9BP04 - NADK_DELAS

Protein

NAD kinase

Gene

nadK

Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801Proton acceptorUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei184 – 1841NADUniRule annotation
    Binding sitei219 – 2191NAD; via carbonyl oxygenUniRule annotation
    Binding sitei253 – 2531NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 812NADUniRule annotation
    Nucleotide bindingi154 – 1552NADUniRule annotation
    Nucleotide bindingi195 – 2006NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDACI398578:GHK3-5501-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Daci_5420
    OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
    Taxonomic identifieri398578 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
    ProteomesiUP000000784: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298NAD kinasePRO_1000120850Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi398578.Daci_5420.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BP04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9BP04-1 [UniParc]FASTAAdd to Basket

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    MTSTFRHVAL IGKYHAPSAS APSENASNAL ERIADFLRRQ GCEVVLDTQS    50
    ALHAGLTDYP TLDVDGLGRH CDLGLVVGGD GTMLGVSRHL AQYGTPLIGV 100
    NQGRLGFVTD IALEDFEATL TPMLQGEYEE DLRPLMCARV IRDGQCVFEA 150
    LAMNDVVVNR GGTSGMVELR IEVGGRFVSN QRADGLIVAT PTGSTAYALS 200
    AGGPMMHPSI PAWVMAPIAP HNLSNRPIVL SDANEVTIEV VAGRDVSANF 250
    DMQSLASLQH GDRILVSRAH HSVRFLHPKG WNYFATLRKK LGWNEGGA 298
    Length:298
    Mass (Da):32,012
    Last modified:January 15, 2008 - v1
    Checksum:iD9CFB822B1660E19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000884 Genomic DNA. Translation: ABX38049.1.
    RefSeqiYP_001566434.1. NC_010002.1.

    Genome annotation databases

    EnsemblBacteriaiABX38049; ABX38049; Daci_5420.
    GeneIDi5751037.
    KEGGidac:Daci_5420.
    PATRICi21644899. VBIDelAci41351_5477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000884 Genomic DNA. Translation: ABX38049.1 .
    RefSeqi YP_001566434.1. NC_010002.1.

    3D structure databases

    ProteinModelPortali A9BP04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 398578.Daci_5420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX38049 ; ABX38049 ; Daci_5420 .
    GeneIDi 5751037.
    KEGGi dac:Daci_5420.
    PATRICi 21644899. VBIDelAci41351_5477.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci DACI398578:GHK3-5501-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Delftia acidovorans DSM 14801 / SPH-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14801 / SPH-1.

    Entry informationi

    Entry nameiNADK_DELAS
    AccessioniPrimary (citable) accession number: A9BP04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3