Reviewed, UniProtKB/Swiss-Prot A9BNR6 (GUAC_DELAS)

Names and origin

Protein names

Recommended name:
    GMP reductase
    EC=1.7.1.7
Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductase
      Short name=Guanosine monophosphate reductase

Gene names

Name:	guaC
Ordered Locus Names:	Daci_5332

Organism

Delftia acidovorans (strain DSM 14801 / SPH-1) [Complete proteome] [HAMAP]

Taxonomic identifier

398578 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Delftia

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity.
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	GMP reductase HAMAP MF_01511		PRO_1000146134
Regions
	Nucleotide binding	202 – 225	24	NADP Potential
Sites
	Active site	173	1	Thioimidate intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9BNR6-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: FE7F6801E987FBFE	FASTA	325	35,702
	10 20 30 40 50 60 MEIFDYDNIL LLPRKCRVES RSECDASVEL GGRSFRIPAV PANMKTVVDE SICTWLAQNG 70 80 90 100 110 120 YFYVMHRFDL DNVQFVREMQ GKGCFASISL GVKKPDYDTV DRFVAEGLCP EYITIDIAHG 130 140 150 160 170 180 HADSVKNMIG YLKEKLPRSF VIAGNVGTPE AVIDLENWGA DATKVGIGPG KVCITKLKTG 190 200 210 220 230 240 FGTGGWQLSA LKWCARVATK PIIADGGIRS HGDIAKSVRF GATMVMIGSL FAGHEESPGQ 250 260 270 280 290 300 TVEENGQRFK EYYGSASDFN KGEYKHVEGK RILEPVKGLL ANTLIEMEQD VQSSISYSGG 310 320 KKLMDIRKVN YVILGGDNAG EHLLM

References

[1]

"Complete sequence of Delftia acidovorans DSM 14801 / SPH-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000884 Genomic DNA. Translation: ABX37961.1.
RefSeq	YP_001566346.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5750944.
GenomeReviews	Gene locus Daci_5332 in contig CP000884_GR.
KEGG	dac:Daci_5332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NSRSECD.
Family and domain databases
HAMAP	MF_01511. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUAC_DELAS

Accession

Primary (citable) accession number: A9BNR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)