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A9BN36 (A9BN36_DELAS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dut HAMAP MF_00116
Ordered Locus Names:Daci_5102
OrganismDelftia acidovorans (strain DSM 14801 / SPH-1) [Complete proteome] [HAMAP]
Taxonomic identifier398578 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Delftia

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region67 – 693Substrate binding By similarity HAMAP MF_00116
Region84 – 863Substrate binding By similarity HAMAP MF_00116

Sites

Binding site801Substrate By similarity HAMAP MF_00116
Binding site941Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
A9BN36 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 274315E9909687A2

FASTA14916,110
        10         20         30         40         50         60 
MNVDIKILDA RLRENMPAYA TPGSAGLDLR ACIDAPLMLE PGQWQLVPTG MAMYLKDPGY 

        70         80         90        100        110        120 
AAMILPRSGM GHKHGIVLGN LVGLIDSDYQ GQLMVSAWNR STTAFTLQPM DRLAQLIIVP 

       130        140 
VVQPSFNVVE EFESTSERGA GGYGSTGKQ

« Hide

References

[1]"Complete sequence of Delftia acidovorans DSM 14801 / SPH-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000884 Genomic DNA. Translation: ABX37731.1.
RefSeqYP_001566116.1. NC_010002.1.

3D structure databases

ProteinModelPortalA9BN36.
SMRA9BN36. Positions 3-135.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9BN36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5750713.
GenomeReviewsGene locus Daci_5102 in contig CP000884_GR.
KEGGdac:Daci_5102.
PATRIC21644237. VBIDelAci41351_5152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG436079.
OMALDLRACI.
ProtClustDBCLSK2797149.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9BN36_DELAS
AccessionPrimary (citable) accession number: A9BN36
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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