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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDACI398578:G1GAI-4912-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Daci_4767
OrganismiDelftia acidovorans (strain DSM 14801 / SPH-1)
Taxonomic identifieri398578 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeDelftia
Proteomesi
  • UP000000784 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900701 – 468Glutamate--tRNA ligaseAdd BLAST468

Proteomic databases

PRIDEiA9BM51

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi398578.Daci_4767

Structurei

3D structure databases

ProteinModelPortaliA9BM51
SMRiA9BM51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi243 – 247"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9BM51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKVRTRFA PSPTGFIHLG NIRSALYPWA FARATGGDFI LRIEDTDVER
60 70 80 90 100
STQASVDVII EGMAWLQLDH DEGPFYQMQR MDRYKEVLAG LQASGHVYPC
110 120 130 140 150
YMSVEELDAL RERQMANKEK PRYDGTWRPE EGKVLPPVPE GVRPVLRFKT
160 170 180 190 200
PQGGVVAWED KCKGRIEFQN SELDDLVIAR PDGTPTYNFC VCVDDMDMAI
210 220 230 240 250
THVIRGDDHV NNTPRQIHIF EALGASVPVF AHLPTVLNEQ GEKMSKRNGA
260 270 280 290 300
KAVTQYRDEG YLPDAMVNYL ARLGWSHGDD EIFSRAQFLE WFNLDHLGRS
310 320 330 340 350
AGQFDEAKLR WVNAQHLKAL DDAALAELVR PFVLKTGLDQ ALLDADDRLP
360 370 380 390 400
RICALFKDRC ETLVDLAGWV RLFYVDAFDR NAEDLAKHVT DVVAPALDAF
410 420 430 440 450
AEGIASVEWS KEAIAALIKE VLKAQGLKMP QLAMPVRVLT LGTAHTPSVD
460
AVLELLGREK ILARLKNR
Length:468
Mass (Da):52,622
Last modified:January 15, 2008 - v1
Checksum:iBDA1B44418FFF3EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000884 Genomic DNA Translation: ABX37396.1
RefSeqiWP_012206566.1, NC_010002.1

Genome annotation databases

EnsemblBacteriaiABX37396; ABX37396; Daci_4767
GeneIDi24118862
KEGGidac:Daci_4767

Similar proteinsi

Entry informationi

Entry nameiSYE_DELAS
AccessioniPrimary (citable) accession number: A9BM51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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