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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei233ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:G1GAG-620-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Pmob_0592
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677341 – 467Glutamate--tRNA ligase 1Add BLAST467

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi403833.Pmob_0592

Structurei

3D structure databases

ProteinModelPortaliA9BJB2
SMRiA9BJB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi230 – 234"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9BJB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVRFAPSP TGHLHVGGLR TALFNWYFAK KNNGKFILRI EDTDMERSKK
60 70 80 90 100
EYEDAILEEM KWVGLDYDEG VDKPGEYGPY RQSERLDIYK HYIDQLLNEE
110 120 130 140 150
KAYFSVTKND EIIFEGNNLL DKYKKNNDYS VVVKFKVNND QKISFLDDVR
160 170 180 190 200
GTIQFDTSNI NDFVILRSNG IPVYNFTVVI DDYLMKISHV IRGEDHISNT
210 220 230 240 250
PKQILIYNAL SFELPKFAHL PLILGEDKSP LSKRHGEVSI TYFREEGYLP
260 270 280 290 300
KAILNYLSLL GWNANEQIFD YTEKYQEFDL KKVSRNPSIF DYTKLLWTNE
310 320 330 340 350
VHLRNDPIEE VHKSFTEWAK YTTVKIDNED SFVKKIIEAS RAKVQTLKQL
360 370 380 390 400
YEFSKNFFVE EFEYEEEFIE KYMKKPWFKQ VIEATIRKLS EIDEYNLANV
410 420 430 440 450
ENTLKEIADL NITSRKNVFQ TIRGSLLGRL VTPGLYESII ILGKNESIKR
460
LKRALEFSNT LDINPRR
Length:467
Mass (Da):54,997
Last modified:January 15, 2008 - v1
Checksum:iB499133D7412F892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA Translation: ABX31326.1
RefSeqiWP_012208430.1, NC_010003.1

Genome annotation databases

EnsemblBacteriaiABX31326; ABX31326; Pmob_0592
KEGGipmo:Pmob_0592

Similar proteinsi

Entry informationi

Entry nameiSYE1_PETMO
AccessioniPrimary (citable) accession number: A9BJB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health