Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9BIX9

- PUR9_PETMO

UniProt

A9BIX9 - PUR9_PETMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1824-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Pmob_1777
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
ProteomesiUP000000789: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bifunctional purine biosynthesis protein PurHPRO_1000076487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1777.

Structurei

3D structure databases

ProteinModelPortaliA9BIX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9BIX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRALLSTY KKEKVVDFAQ TLQELGIEII STGGTAKKLQ ENSIEVTPVE
60 70 80 90 100
EITNFPEILN GRVKTLNPFI QGGILARREN KQDMETLENL KIEPIDLIYV
110 120 130 140 150
NLYPFVEVAN KRDVDMNELI EFIDIGGPTM IRSAAKNYKD VIVVVDESDL
160 170 180 190 200
EQISAKLKTP EELDENYRLY LASKAFNLTA FYDSCISNYL NAQLTNKDDF
210 220 230 240 250
QEFLTVPFEK SYEMRYGENP HQSAIFYKNT LTSGAMTSFE QLNGKELSFN
260 270 280 290 300
NLRDADSAWK AVNEFEDTAC CCLKHSSPCG IALGDSVIEA YQKAYSCDPV
310 320 330 340 350
SIFGGIVAFN RKIDVETALE LKKIFLEIIM APEYDEEALD ILKEKKNLRI
360 370 380 390 400
LKMNSKPIDT YEYVSVDGGI LVQEVDKRVI NEFEVVTETK VSEEIKEELL
410 420 430 440 450
FAWKAVKHVK SNAIVVSKNK ATTGIGAGQP NRIWAATQAL ERSKDKGGDV
460 470 480 490 500
LASDAFFPFS DVVEKAAEYG IKAIIQPGGS IRDDESIQAC SKYGIAMVFT

GMRHFKHI
Length:508
Mass (Da):57,068
Last modified:January 15, 2008 - v1
Checksum:i99BFEB1EFF966C0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32467.1.
RefSeqiYP_001568790.1. NC_010003.1.

Genome annotation databases

EnsemblBacteriaiABX32467; ABX32467; Pmob_1777.
GeneIDi5757923.
KEGGipmo:Pmob_1777.
PATRICi22921380. VBIPetMob40494_1902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32467.1 .
RefSeqi YP_001568790.1. NC_010003.1.

3D structure databases

ProteinModelPortali A9BIX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 403833.Pmob_1777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX32467 ; ABX32467 ; Pmob_1777 .
GeneIDi 5757923.
KEGGi pmo:Pmob_1777.
PATRICi 22921380. VBIPetMob40494_1902.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMOB403833:GH51-1824-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10674 / SJ95.

Entry informationi

Entry nameiPUR9_PETMO
AccessioniPrimary (citable) accession number: A9BIX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3