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A9BIX9

- PUR9_PETMO

UniProt

A9BIX9 - PUR9_PETMO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Pmob_1777
Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1824-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Pmob_1777
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
ProteomesiUP000000789: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1777.

Structurei

3D structure databases

ProteinModelPortaliA9BIX9.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9BIX9-1 [UniParc]FASTAAdd to Basket

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MIKRALLSTY KKEKVVDFAQ TLQELGIEII STGGTAKKLQ ENSIEVTPVE    50
EITNFPEILN GRVKTLNPFI QGGILARREN KQDMETLENL KIEPIDLIYV 100
NLYPFVEVAN KRDVDMNELI EFIDIGGPTM IRSAAKNYKD VIVVVDESDL 150
EQISAKLKTP EELDENYRLY LASKAFNLTA FYDSCISNYL NAQLTNKDDF 200
QEFLTVPFEK SYEMRYGENP HQSAIFYKNT LTSGAMTSFE QLNGKELSFN 250
NLRDADSAWK AVNEFEDTAC CCLKHSSPCG IALGDSVIEA YQKAYSCDPV 300
SIFGGIVAFN RKIDVETALE LKKIFLEIIM APEYDEEALD ILKEKKNLRI 350
LKMNSKPIDT YEYVSVDGGI LVQEVDKRVI NEFEVVTETK VSEEIKEELL 400
FAWKAVKHVK SNAIVVSKNK ATTGIGAGQP NRIWAATQAL ERSKDKGGDV 450
LASDAFFPFS DVVEKAAEYG IKAIIQPGGS IRDDESIQAC SKYGIAMVFT 500
GMRHFKHI 508
Length:508
Mass (Da):57,068
Last modified:January 15, 2008 - v1
Checksum:i99BFEB1EFF966C0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000879 Genomic DNA. Translation: ABX32467.1.
RefSeqiWP_012209564.1. NC_010003.1.
YP_001568790.1. NC_010003.1.

Genome annotation databases

EnsemblBacteriaiABX32467; ABX32467; Pmob_1777.
GeneIDi5757923.
KEGGipmo:Pmob_1777.
PATRICi22921380. VBIPetMob40494_1902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000879 Genomic DNA. Translation: ABX32467.1 .
RefSeqi WP_012209564.1. NC_010003.1.
YP_001568790.1. NC_010003.1.

3D structure databases

ProteinModelPortali A9BIX9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 403833.Pmob_1777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX32467 ; ABX32467 ; Pmob_1777 .
GeneIDi 5757923.
KEGGi pmo:Pmob_1777.
PATRICi 22921380. VBIPetMob40494_1902.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMOB403833:GH51-1824-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10674 / SJ95.

Entry informationi

Entry nameiPUR9_PETMO
AccessioniPrimary (citable) accession number: A9BIX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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