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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:G1GAG-1807-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Pmob_1756
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000876531 – 554Formate--tetrahydrofolate ligaseAdd BLAST554

Proteomic databases

PRIDEiA9BIV8

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1756

Structurei

3D structure databases

ProteinModelPortaliA9BIV8
SMRiA9BIV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9BIV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDIEIARS AKLKKIDLIA NELDIPEEYY NLYGKNIAKV SHKYLNELNF
60 70 80 90 100
KNDGNLVMVT AITPTPAGEG KTTTSISLSM ALNKIHKRSI VTLREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYSQVLPME DINLHFTGDI HAVTSAHNLI SAILDDYIKY
160 170 180 190 200
NKYDIDSTQV SWPRTMDMND RALREIIVAL GGKKNGYPRQ DGFIITAASE
210 220 230 240 250
IMAILCLIEN LEDLKKKLSN IVVAKNKKGE PVTVKDLEIT GALSVLLKDA
260 270 280 290 300
INPNLVQTIE NTPAFVHGGP FANIAHGTNS ILATKLALKL SDYVVTETGF
310 320 330 340 350
GSDLGGEKFY DFVSPTFGLK PSATVLVATI RALKYHGGQN LKDLNTPNLE
360 370 380 390 400
SLEKGLPNLQ VHVENLKKYN IPVVVSLNKF YSDTDEEINM VKDYCDKLGV
410 420 430 440 450
EVSVNEGFEK GSEGAIDLAE KVVKVSEQQS ELKSIYDFKD PLEVKIEKLA
460 470 480 490 500
KNIYRASKVE YSSEALSTIK FLKKYGYENL PVIVAKTQYS ISDDPKKLGF
510 520 530 540 550
PKDYTFTIRD FELSAGAGFI VALAGDILRM PGLSKVPNAV NMDIDNEGNI

SGLS
Length:554
Mass (Da):60,679
Last modified:January 15, 2008 - v1
Checksum:i1C527EF6D73AB44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA Translation: ABX32446.1
RefSeqiWP_012209543.1, NC_010003.1

Genome annotation databases

EnsemblBacteriaiABX32446; ABX32446; Pmob_1756
KEGGipmo:Pmob_1756

Similar proteinsi

Entry informationi

Entry nameiFTHS_PETMO
AccessioniPrimary (citable) accession number: A9BIV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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