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A9BIV8 (FTHS_PETMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Pmob_1756
OrganismPetrotoga mobilis (strain DSM 10674 / SJ95) [Complete proteome] [HAMAP]
Taxonomic identifier403833 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087653

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9BIV8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 1C527EF6D73AB44A

FASTA55460,679
        10         20         30         40         50         60 
MLSDIEIARS AKLKKIDLIA NELDIPEEYY NLYGKNIAKV SHKYLNELNF KNDGNLVMVT 

        70         80         90        100        110        120 
AITPTPAGEG KTTTSISLSM ALNKIHKRSI VTLREPSLGP VMGIKGGAAG GGYSQVLPME 

       130        140        150        160        170        180 
DINLHFTGDI HAVTSAHNLI SAILDDYIKY NKYDIDSTQV SWPRTMDMND RALREIIVAL 

       190        200        210        220        230        240 
GGKKNGYPRQ DGFIITAASE IMAILCLIEN LEDLKKKLSN IVVAKNKKGE PVTVKDLEIT 

       250        260        270        280        290        300 
GALSVLLKDA INPNLVQTIE NTPAFVHGGP FANIAHGTNS ILATKLALKL SDYVVTETGF 

       310        320        330        340        350        360 
GSDLGGEKFY DFVSPTFGLK PSATVLVATI RALKYHGGQN LKDLNTPNLE SLEKGLPNLQ 

       370        380        390        400        410        420 
VHVENLKKYN IPVVVSLNKF YSDTDEEINM VKDYCDKLGV EVSVNEGFEK GSEGAIDLAE 

       430        440        450        460        470        480 
KVVKVSEQQS ELKSIYDFKD PLEVKIEKLA KNIYRASKVE YSSEALSTIK FLKKYGYENL 

       490        500        510        520        530        540 
PVIVAKTQYS ISDDPKKLGF PKDYTFTIRD FELSAGAGFI VALAGDILRM PGLSKVPNAV 

       550 
NMDIDNEGNI SGLS 

« Hide

References

[1]"Complete sequence of Petroga mobilis SJ95."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Noll K., Richardson P.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 10674 / SJ95.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000879 Genomic DNA. Translation: ABX32446.1.
RefSeqYP_001568769.1. NC_010003.1.

3D structure databases

ProteinModelPortalA9BIV8.
SMRA9BIV8. Positions 4-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING403833.Pmob_1756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX32446; ABX32446; Pmob_1756.
GeneID5757754.
KEGGpmo:Pmob_1756.
PATRIC22921336. VBIPetMob40494_1880.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycPMOB403833:GH51-1803-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PETMO
AccessionPrimary (citable) accession number: A9BIV8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways