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A9BIV8

- FTHS_PETMO

UniProt

A9BIV8 - FTHS_PETMO

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1803-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Pmob_1756
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
ProteomesiUP000000789: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000087653Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1756.

Structurei

3D structure databases

ProteinModelPortaliA9BIV8.
SMRiA9BIV8. Positions 4-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9BIV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEIARS AKLKKIDLIA NELDIPEEYY NLYGKNIAKV SHKYLNELNF
60 70 80 90 100
KNDGNLVMVT AITPTPAGEG KTTTSISLSM ALNKIHKRSI VTLREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYSQVLPME DINLHFTGDI HAVTSAHNLI SAILDDYIKY
160 170 180 190 200
NKYDIDSTQV SWPRTMDMND RALREIIVAL GGKKNGYPRQ DGFIITAASE
210 220 230 240 250
IMAILCLIEN LEDLKKKLSN IVVAKNKKGE PVTVKDLEIT GALSVLLKDA
260 270 280 290 300
INPNLVQTIE NTPAFVHGGP FANIAHGTNS ILATKLALKL SDYVVTETGF
310 320 330 340 350
GSDLGGEKFY DFVSPTFGLK PSATVLVATI RALKYHGGQN LKDLNTPNLE
360 370 380 390 400
SLEKGLPNLQ VHVENLKKYN IPVVVSLNKF YSDTDEEINM VKDYCDKLGV
410 420 430 440 450
EVSVNEGFEK GSEGAIDLAE KVVKVSEQQS ELKSIYDFKD PLEVKIEKLA
460 470 480 490 500
KNIYRASKVE YSSEALSTIK FLKKYGYENL PVIVAKTQYS ISDDPKKLGF
510 520 530 540 550
PKDYTFTIRD FELSAGAGFI VALAGDILRM PGLSKVPNAV NMDIDNEGNI

SGLS
Length:554
Mass (Da):60,679
Last modified:January 15, 2008 - v1
Checksum:i1C527EF6D73AB44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32446.1.
RefSeqiWP_012209543.1. NC_010003.1.
YP_001568769.1. NC_010003.1.

Genome annotation databases

EnsemblBacteriaiABX32446; ABX32446; Pmob_1756.
GeneIDi5757754.
KEGGipmo:Pmob_1756.
PATRICi22921336. VBIPetMob40494_1880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32446.1 .
RefSeqi WP_012209543.1. NC_010003.1.
YP_001568769.1. NC_010003.1.

3D structure databases

ProteinModelPortali A9BIV8.
SMRi A9BIV8. Positions 4-552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 403833.Pmob_1756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX32446 ; ABX32446 ; Pmob_1756 .
GeneIDi 5757754.
KEGGi pmo:Pmob_1756.
PATRICi 22921336. VBIPetMob40494_1880.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PMOB403833:GH51-1803-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10674 / SJ95.

Entry informationi

Entry nameiFTHS_PETMO
AccessioniPrimary (citable) accession number: A9BIV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3