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Protein

Alanine racemase

Gene

Pmob_1646

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Pmob_1646)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Active sitei261Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei309Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1635-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Pmob_1646Imported
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)Imported
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1646.

Structurei

3D structure databases

ProteinModelPortaliA9BI49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 367Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

A9BI49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGRETAAYI NIDKYLENLN YIQNQTKAHI IPVLKANAYG HGMLPLAMQV
60 70 80 90 100
FKEGYSMLAV AYLEEALEIL NRGIHLPILI FNYFSPDDFK ELLEFAHFLR
110 120 130 140 150
PTITSSTFLE KVCDILGKDV DKFKFHINVD TGINRIGIKE EKLPQLIKLI
160 170 180 190 200
KDRNIQIEGV YSHFANADEK DDFTRVQFEK YKGLLDYIIG SGIDVEKKHI
210 220 230 240 250
SNSAAALFFP EFALDYVRPG IATYGLQPST TYKIDQLKPI LELKSIVANI
260 270 280 290 300
QNLQPNDTIG YGRTYEVQKR MKTAIVPIGY ADGYFRALSN KGEVLINGKR
310 320 330 340 350
SKILGRVSMD QIVVDVTDNN VSLGDEVVII GRQKYDQITA EEVAENASTI
360 370
NYEVTSRIAQ RVRRIYIKGG KYFE
Length:374
Mass (Da):42,496
Last modified:January 15, 2008 - v1
Checksum:iC77DE05F706C83C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32340.1.

Genome annotation databases

EnsemblBacteriaiABX32340; ABX32340; Pmob_1646.
KEGGipmo:Pmob_1646.

Similar proteinsi

Entry informationi

Entry nameiA9BI49_PETMO
AccessioniPrimary (citable) accession number: A9BI49
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported