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Protein

NAD kinase

Gene

nadK

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591Proton acceptorUniRule annotation
Binding sitei64 – 641NADUniRule annotation
Binding sitei158 – 1581NADUniRule annotation
Binding sitei193 – 1931NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 602NADUniRule annotation
Nucleotide bindingi128 – 1292NADUniRule annotation
Nucleotide bindingi169 – 1746NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Pmob_1354
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
ProteomesiUP000000789 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274NAD kinasePRO_1000079504Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_1354.

Structurei

3D structure databases

ProteinModelPortaliA9BHU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiAYIDNEF.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A9BHU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFIFYNPL KLSNDDLEEN ILKPFNESNI EVIGYAAAGS TVEEKQAQVA
60 70 80 90 100
DFFVIFGGDG TVLKIAEIAA IFSKPVIAVN TGNLGFLSSY SSSEIKELIE
110 120 130 140 150
DIQKENISFS FRHLLECHVG TKKVVVLNDI VLLKSQPLGT MNVDVKIEEH
160 170 180 190 200
TLFSFAGDGL IVSTPTGSTA YALSAGGPII HPELNVVQLI PLAAHALNIR
210 220 230 240 250
PFIAPPTQRI EIILKNMSKG FVYVTGDGDI IHRMEPGMSI FVTSSEMTIK
260 270
LAQRNGNNYL NALDKKLGFG RRFE
Length:274
Mass (Da):30,017
Last modified:January 15, 2008 - v1
Checksum:iFBF25E5E4621BAB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32058.1.
RefSeqiWP_012209157.1. NC_010003.1.
YP_001568381.1. NC_010003.1.

Genome annotation databases

EnsemblBacteriaiABX32058; ABX32058; Pmob_1354.
KEGGipmo:Pmob_1354.
PATRICi22920450. VBIPetMob40494_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA. Translation: ABX32058.1.
RefSeqiWP_012209157.1. NC_010003.1.
YP_001568381.1. NC_010003.1.

3D structure databases

ProteinModelPortaliA9BHU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi403833.Pmob_1354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX32058; ABX32058; Pmob_1354.
KEGGipmo:Pmob_1354.
PATRICi22920450. VBIPetMob40494_1447.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiAYIDNEF.
OrthoDBiEOG6PZXDR.

Enzyme and pathway databases

BioCyciPMOB403833:GH51-1389-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10674 / SJ95.

Entry informationi

Entry nameiNADK_PETMO
AccessioniPrimary (citable) accession number: A9BHU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: May 27, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.