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A9BHU3

- NADK_PETMO

UniProt

A9BHU3 - NADK_PETMO

Protein

NAD kinase

Gene

nadK

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591Proton acceptorUniRule annotation
    Binding sitei64 – 641NADUniRule annotation
    Binding sitei158 – 1581NADUniRule annotation
    Binding sitei193 – 1931NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi59 – 602NADUniRule annotation
    Nucleotide bindingi128 – 1292NADUniRule annotation
    Nucleotide bindingi169 – 1746NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMOB403833:GH51-1389-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Pmob_1354
    OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
    Taxonomic identifieri403833 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
    ProteomesiUP000000789: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274NAD kinasePRO_1000079504Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi403833.Pmob_1354.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BHU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiNLSERGP.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9BHU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIFIFYNPL KLSNDDLEEN ILKPFNESNI EVIGYAAAGS TVEEKQAQVA    50
    DFFVIFGGDG TVLKIAEIAA IFSKPVIAVN TGNLGFLSSY SSSEIKELIE 100
    DIQKENISFS FRHLLECHVG TKKVVVLNDI VLLKSQPLGT MNVDVKIEEH 150
    TLFSFAGDGL IVSTPTGSTA YALSAGGPII HPELNVVQLI PLAAHALNIR 200
    PFIAPPTQRI EIILKNMSKG FVYVTGDGDI IHRMEPGMSI FVTSSEMTIK 250
    LAQRNGNNYL NALDKKLGFG RRFE 274
    Length:274
    Mass (Da):30,017
    Last modified:January 15, 2008 - v1
    Checksum:iFBF25E5E4621BAB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX32058.1.
    RefSeqiWP_012209157.1. NC_010003.1.
    YP_001568381.1. NC_010003.1.

    Genome annotation databases

    EnsemblBacteriaiABX32058; ABX32058; Pmob_1354.
    GeneIDi5758165.
    KEGGipmo:Pmob_1354.
    PATRICi22920450. VBIPetMob40494_1447.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX32058.1 .
    RefSeqi WP_012209157.1. NC_010003.1.
    YP_001568381.1. NC_010003.1.

    3D structure databases

    ProteinModelPortali A9BHU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 403833.Pmob_1354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX32058 ; ABX32058 ; Pmob_1354 .
    GeneIDi 5758165.
    KEGGi pmo:Pmob_1354.
    PATRICi 22920450. VBIPetMob40494_1447.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi NLSERGP.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PMOB403833:GH51-1389-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10674 / SJ95.

    Entry informationi

    Entry nameiNADK_PETMO
    AccessioniPrimary (citable) accession number: A9BHU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3