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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei80Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei88PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi92Magnesium 1UniRule annotation1
Binding sitei111Anthranilate 1UniRule annotation1
Binding sitei120Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei166Anthranilate 2UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1
Metal bindingi226Magnesium 1UniRule annotation1
Metal bindingi226Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPMOB403833:G1GAG-1246-MONOMER
UniPathwayiUPA00035; UER00041

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Pmob_1211
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000780211 – 344Anthranilate phosphoribosyltransferaseAdd BLAST344

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi403833.Pmob_1211

Structurei

3D structure databases

ProteinModelPortaliA9BHQ6
SMRiA9BHQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni90 – 93Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni108 – 116Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0547 LUCA
HOGENOMiHOG000230451
KOiK00766
OMAiLCALKIK
OrthoDBiPOG091H01QX

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
HAMAPiMF_00211 TrpD, 1 hit
InterProiView protein in InterPro
IPR005940 Anthranilate_Pribosyl_Tfrase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
TIGRFAMsiTIGR01245 trpD, 1 hit

Sequencei

Sequence statusi: Complete.

A9BHQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNYYLQKVV KGENLSLDEM EQAMEMIMEG KVTHSQLSGF LVALHMKGET
60 70 80 90 100
VEEITASAKV MKEKATPISI ESGELMDTCG TGGDAKGTFN ISTAVAFILA
110 120 130 140 150
AAGVVVAKHG NRSVSSKSGS ADVLESLGIN ISLPPSSVER CLKEINIAFL
160 170 180 190 200
FAQDFHKATK HAAVPRKELG IRTIFNVLGP LTNPANIKYQ LMGIYDPKLV
210 220 230 240 250
YPIAEVLNNL GVKRAMVVHG SEGIDEFSLS GKNKVAFLNE GKIEKLEISP
260 270 280 290 300
EDLGLEKYSI QEIQGGSAEE NKRIILNIFN GEMGPKRDVV VLNTAAGLYV
310 320 330 340
ANKVNSLEEG INFAQEIIDS GKAMKKLEEM VEFTNFLSLQ AKTS
Length:344
Mass (Da):37,333
Last modified:January 15, 2008 - v1
Checksum:iAA6057C781BABD98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA Translation: ABX31928.1
RefSeqiWP_012209028.1, NC_010003.1

Genome annotation databases

EnsemblBacteriaiABX31928; ABX31928; Pmob_1211
KEGGipmo:Pmob_1211

Similar proteinsi

Entry informationi

Entry nameiTRPD_PETMO
AccessioniPrimary (citable) accession number: A9BHQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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