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Protein

Endonuclease V

Gene

nfi

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43MagnesiumUniRule annotation1
Metal bindingi109MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPMOB403833:G1GAG-1209-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:Pmob_1173
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000836971 – 221Endonuclease VAdd BLAST221

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei79Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi403833.Pmob_1173

Structurei

3D structure databases

ProteinModelPortaliA9BHL9
SMRiA9BHL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X Bacteria
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE
OrthoDBiPOG091H0CQB

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

A9BHL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYKPVHRFD MSPKDMIKVQ KQLAKEVKLI HFSDEPNLVS GVDLSFPKDE
60 70 80 90 100
GLAVIVTMDF KKLSVIDVTY AVDKITLPYI PGLLAFRELP IFLKAWEKLE
110 120 130 140 150
IEPDIVFFDG QGYAHPRRMG IATHASFFIE KPTIGIAKSK LIGEYEEPGK
160 170 180 190 200
KKGEFTFLYH KDEKIGIVLR TRDNVKPVFV SPGNLVDFNN ALDFTYHFAT
210 220
KYKIPEITRK AHLYTQSLKQ R
Length:221
Mass (Da):25,422
Last modified:January 15, 2008 - v1
Checksum:i731DF028F94C34EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA Translation: ABX31891.1
RefSeqiWP_012208992.1, NC_010003.1

Genome annotation databases

EnsemblBacteriaiABX31891; ABX31891; Pmob_1173
KEGGipmo:Pmob_1173

Similar proteinsi

Entry informationi

Entry nameiNFI_PETMO
AccessioniPrimary (citable) accession number: A9BHL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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