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A9BH73

- PNP_PETMO

UniProt

A9BH73 - PNP_PETMO

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi492 – 4921MagnesiumUniRule annotation
    Metal bindingi498 – 4981MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciPMOB403833:GH51-585-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Pmob_0569
    OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
    Taxonomic identifieri403833 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
    ProteomesiUP000000789: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Polyribonucleotide nucleotidyltransferasePRO_0000329756Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi403833.Pmob_0569.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BH73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini559 – 61860KHUniRule annotationAdd
    BLAST
    Domaini628 – 69164S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BH73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLEKELFG RKLRIEHGKV AKQSLGSVML TFNESTILVT ADASEETVKG    50
    QDFFPLTVEF QEKFYAVGKI PGGFIKREGK PSDEAILAAR LIDRPIRPLF 100
    PENFFNEVQV ITTVFSMLNG DSIETWGITG ASLALNLSPI PFNGIVAGVR 150
    IGYVDGQFIA FPTQEQLKNS KIDMVVAGTK DAVTMVEGES LEVSEEEMVE 200
    ALMFAQEKIK EIIAIEEEFL SELNIEKWEV QKEIVPEEFI EDYLSLIDEE 250
    ELKKVLLTKG KKNRDKVISE YKKNVMKKFE EIFLEKWSVA FFEDKKRFLE 300
    NAFEEKLQDS MRKMIINENK RVDGRTCDEI RDITCEVGLI PRVHGSALFT 350
    RGETQSLGTV TLGAPLDVQV LDTIFSDEEK RFMLHYNFPP FSTGEVKRLR 400
    GVSRREIGHG HLAERAHKNL IPSDEEFPYT IRVVSDILES NGSSSMASVC 450
    SASLALMDAG VPIQKHVAGI AMGLIFENDN FVVLTDILGM EDHLGDMDFK 500
    VAGTRDGITA FQMDVKTSQV NKEVLQKALE KAKIARLKIL DKMYETIPQP 550
    RKELSPYVPI MKVFKIPVSK IGEVIGPGGK NIKEISELYN VEVYIEDDGK 600
    VKVTGHNANK VDEAINHIQN LIAQVEKGGI FEGTVKRVEK YGIFVEVLPG 650
    KVGMLHVSNL KDKLESFKIG DKVKVEVMKV EDQGKFQLKQ LKEEN 695
    Length:695
    Mass (Da):78,198
    Last modified:January 15, 2008 - v1
    Checksum:iE9F95A0FC9020DF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX31303.1.
    RefSeqiYP_001567626.1. NC_010003.1.

    Genome annotation databases

    EnsemblBacteriaiABX31303; ABX31303; Pmob_0569.
    GeneIDi5757941.
    KEGGipmo:Pmob_0569.
    PATRICi22918712. VBIPetMob40494_0596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX31303.1 .
    RefSeqi YP_001567626.1. NC_010003.1.

    3D structure databases

    ProteinModelPortali A9BH73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 403833.Pmob_0569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX31303 ; ABX31303 ; Pmob_0569 .
    GeneIDi 5757941.
    KEGGi pmo:Pmob_0569.
    PATRICi 22918712. VBIPetMob40494_0596.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci PMOB403833:GH51-585-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10674 / SJ95.

    Entry informationi

    Entry nameiPNP_PETMO
    AccessioniPrimary (citable) accession number: A9BH73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3