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A9BGT8

- SYE2_PETMO

UniProt

A9BGT8 - SYE2_PETMO

Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei257 – 2571ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMOB403833:GH51-1878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetase 2UniRule annotation
    Short name:
    GluRS 2UniRule annotation
    Gene namesi
    Name:gltX2UniRule annotation
    Ordered Locus Names:Pmob_1830
    OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
    Taxonomic identifieri403833 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
    ProteomesiUP000000789: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Glutamate--tRNA ligase 2PRO_0000367743Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi403833.Pmob_1830.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BGT8.
    SMRiA9BGT8. Positions 5-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2211"HIGH" regionAdd
    BLAST
    Motifi254 – 2585"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252722.
    KOiK09698.
    OMAiKLEWYNG.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BGT8-1 [UniParc]FASTAAdd to Basket

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    MISNTVRTRF APSPTGYLHV GGARTALFNY LFSKKNEGKF ILRIEDTDIE    50
    RSTKESEDQL INTLKWLNLN WDEGPIIGGD YEPYRQSERL EIYQRRAKEL 100
    IEKGKAYEAY ISPEEIEEVK NQLISEGKPP HYTYDLISKY NTKERIEEYN 150
    YKGLKPVIFL KMPQKDYELD DKIKGKVIFK KGSIGDFIIL RSNGIPTYNF 200
    AVVVDDIEMK ITHVIRGDDH LPNTLRQMAI YEAFEVEPPI FAHVSMILGP 250
    DGKKLSKRHG ATSVEEFMVQ GYLPEAVDNY LALLGWSHPE GKEILPLSEI 300
    IDNFTLDRVN SSPAIFDEKK LKWMNGQYLR NKPLEEIYQL AEPFVTGSKL 350
    LSKEQYEVNK KWVIKALETI LSSVEILSEI PEKMEVFLKD VYPDTNDPEF 400
    KEYFDKRGVK EAINLIYKYF NEDDRWDTQT ITENLKNAMN EANPQKKPFY 450
    MSLRKILTDS FHGPDLINTI FLLGRNTVLE RLQRVIEI 488
    Length:488
    Mass (Da):56,768
    Last modified:January 15, 2008 - v1
    Checksum:i8409936946E89202
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX32519.1.
    RefSeqiYP_001568842.1. NC_010003.1.

    Genome annotation databases

    EnsemblBacteriaiABX32519; ABX32519; Pmob_1830.
    GeneIDi5758046.
    KEGGipmo:Pmob_1830.
    PATRICi22921502. VBIPetMob40494_1962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX32519.1 .
    RefSeqi YP_001568842.1. NC_010003.1.

    3D structure databases

    ProteinModelPortali A9BGT8.
    SMRi A9BGT8. Positions 5-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 403833.Pmob_1830.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX32519 ; ABX32519 ; Pmob_1830 .
    GeneIDi 5758046.
    KEGGi pmo:Pmob_1830.
    PATRICi 22921502. VBIPetMob40494_1962.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252722.
    KOi K09698.
    OMAi KLEWYNG.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci PMOB403833:GH51-1878-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10674 / SJ95.

    Entry informationi

    Entry nameiSYE2_PETMO
    AccessioniPrimary (citable) accession number: A9BGT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3