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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei585ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:G1GAG-357-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pmob_0344
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaePetrotoga
Proteomesi
  • UP000000789 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001992171 – 828Leucine--tRNA ligaseAdd BLAST828

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_0344

Structurei

3D structure databases

ProteinModelPortaliA9BF22
SMRiA9BF22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi582 – 586"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9BF22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTYNPQEI ERKWQRNWQE KDAFKVSNEE YHKKYYDLVM FPYPSGTLHV
60 70 80 90 100
GHVKNYVIGD VIARYKRMRG YNVMHPFGFD AFGLPAENAA IEKGNIHPED
110 120 130 140 150
WTMQNINIIR NQIKKLGISY NWEREVITCK EDYYKWTQWI FLQLYKNGLA
160 170 180 190 200
YKKKAPVNWC PNCKTVLANE QVVNGKCERC GTVVEIKQLE QWYFKITDYA
210 220 230 240 250
EKLLYDLEKL SGWPENVKIM QKNWIGKSVG AEVEFNLDNG KGSLRVFTTR
260 270 280 290 300
PDTLWGVTFM ALAPESPLVE ELTTPENSEK VNQFLQRVSL QDRFKRTAEG
310 320 330 340 350
AEKEGVFTGS YAINPVNGEK IPIYVANYIL YEYGTGAIMA VPAHDQRDFE
360 370 380 390 400
FAKKYDLPIR IVIMPEGDEL TEENLEKAYI GEGVLVNSGE FTGLDNQTAI
410 420 430 440 450
REVSQWLEDK KIGKVVTQYK LRDWLISRQR YWGAPIPVVY CEKCGVVPVP
460 470 480 490 500
EKDLPVKLPR DVAFEPTGKS PLIDHPDFKE TTCPKCGGKA KREVDTMDTF
510 520 530 540 550
VDSSWYYLRY VNPKLEDKPF NKEDVDNWLP VDQYIGGVEH AILHLLYSRF
560 570 580 590 600
ITKVLKDLGY VSFDEPFKNL FTQGMIYRNG AKMSKSKGNV VSPEEMIEKY
610 620 630 640 650
GTDALRTYIL FMAPPERDAE WNDSGIEGTY RFLNKVWNTY MKIQDKIIHL
660 670 680 690 700
ENKPNYPLKN KSEKDLRRKL HQTIEKITSD IEGNFQFNTA VSSLMELLNE
710 720 730 740 750
LNSYLNNTDD KDWNLNLLKE FSEDFVLMLS PIAPHISEEL WKNFGKDEFI
760 770 780 790 800
FKASWPEIDK NALKAEEITL AVQINGKLRA QITVDVSLNE DEVKSYALED
810 820
DKVQKYISGK KIQKIIYVPK KIINIVVK
Length:828
Mass (Da):96,100
Last modified:January 15, 2008 - v1
Checksum:iF65300E294F9C3E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000879 Genomic DNA Translation: ABX31086.1
RefSeqiWP_012208193.1, NC_010003.1

Genome annotation databases

EnsemblBacteriaiABX31086; ABX31086; Pmob_0344
KEGGipmo:Pmob_0344

Similar proteinsi

Entry informationi

Entry nameiSYL_PETMO
AccessioniPrimary (citable) accession number: A9BF22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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