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A9BF22

- SYL_PETMO

UniProt

A9BF22 - SYL_PETMO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei585 – 5851ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMOB403833:GH51-352-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pmob_0344
    OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
    Taxonomic identifieri403833 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
    ProteomesiUP000000789: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 828828Leucine--tRNA ligasePRO_1000199217Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi403833.Pmob_0344.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BF22.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi582 – 5865"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BF22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKTYNPQEI ERKWQRNWQE KDAFKVSNEE YHKKYYDLVM FPYPSGTLHV    50
    GHVKNYVIGD VIARYKRMRG YNVMHPFGFD AFGLPAENAA IEKGNIHPED 100
    WTMQNINIIR NQIKKLGISY NWEREVITCK EDYYKWTQWI FLQLYKNGLA 150
    YKKKAPVNWC PNCKTVLANE QVVNGKCERC GTVVEIKQLE QWYFKITDYA 200
    EKLLYDLEKL SGWPENVKIM QKNWIGKSVG AEVEFNLDNG KGSLRVFTTR 250
    PDTLWGVTFM ALAPESPLVE ELTTPENSEK VNQFLQRVSL QDRFKRTAEG 300
    AEKEGVFTGS YAINPVNGEK IPIYVANYIL YEYGTGAIMA VPAHDQRDFE 350
    FAKKYDLPIR IVIMPEGDEL TEENLEKAYI GEGVLVNSGE FTGLDNQTAI 400
    REVSQWLEDK KIGKVVTQYK LRDWLISRQR YWGAPIPVVY CEKCGVVPVP 450
    EKDLPVKLPR DVAFEPTGKS PLIDHPDFKE TTCPKCGGKA KREVDTMDTF 500
    VDSSWYYLRY VNPKLEDKPF NKEDVDNWLP VDQYIGGVEH AILHLLYSRF 550
    ITKVLKDLGY VSFDEPFKNL FTQGMIYRNG AKMSKSKGNV VSPEEMIEKY 600
    GTDALRTYIL FMAPPERDAE WNDSGIEGTY RFLNKVWNTY MKIQDKIIHL 650
    ENKPNYPLKN KSEKDLRRKL HQTIEKITSD IEGNFQFNTA VSSLMELLNE 700
    LNSYLNNTDD KDWNLNLLKE FSEDFVLMLS PIAPHISEEL WKNFGKDEFI 750
    FKASWPEIDK NALKAEEITL AVQINGKLRA QITVDVSLNE DEVKSYALED 800
    DKVQKYISGK KIQKIIYVPK KIINIVVK 828
    Length:828
    Mass (Da):96,100
    Last modified:January 15, 2008 - v1
    Checksum:iF65300E294F9C3E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX31086.1.
    RefSeqiYP_001567409.1. NC_010003.1.

    Genome annotation databases

    EnsemblBacteriaiABX31086; ABX31086; Pmob_0344.
    GeneIDi5758364.
    KEGGipmo:Pmob_0344.
    PATRICi22918226. VBIPetMob40494_0360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000879 Genomic DNA. Translation: ABX31086.1 .
    RefSeqi YP_001567409.1. NC_010003.1.

    3D structure databases

    ProteinModelPortali A9BF22.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 403833.Pmob_0344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX31086 ; ABX31086 ; Pmob_0344 .
    GeneIDi 5758364.
    KEGGi pmo:Pmob_0344.
    PATRICi 22918226. VBIPetMob40494_0360.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMOB403833:GH51-352-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10674 / SJ95.

    Entry informationi

    Entry nameiSYL_PETMO
    AccessioniPrimary (citable) accession number: A9BF22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3