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A9BF22

- SYL_PETMO

UniProt

A9BF22 - SYL_PETMO

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Petrotoga mobilis (strain DSM 10674 / SJ95)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMOB403833:GH51-352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pmob_0344
OrganismiPetrotoga mobilis (strain DSM 10674 / SJ95)
Taxonomic identifieri403833 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePetrotoga
ProteomesiUP000000789: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 828828Leucine--tRNA ligasePRO_1000199217Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi403833.Pmob_0344.

Structurei

3D structure databases

ProteinModelPortaliA9BF22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi582 – 5865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9BF22 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKTYNPQEI ERKWQRNWQE KDAFKVSNEE YHKKYYDLVM FPYPSGTLHV
60 70 80 90 100
GHVKNYVIGD VIARYKRMRG YNVMHPFGFD AFGLPAENAA IEKGNIHPED
110 120 130 140 150
WTMQNINIIR NQIKKLGISY NWEREVITCK EDYYKWTQWI FLQLYKNGLA
160 170 180 190 200
YKKKAPVNWC PNCKTVLANE QVVNGKCERC GTVVEIKQLE QWYFKITDYA
210 220 230 240 250
EKLLYDLEKL SGWPENVKIM QKNWIGKSVG AEVEFNLDNG KGSLRVFTTR
260 270 280 290 300
PDTLWGVTFM ALAPESPLVE ELTTPENSEK VNQFLQRVSL QDRFKRTAEG
310 320 330 340 350
AEKEGVFTGS YAINPVNGEK IPIYVANYIL YEYGTGAIMA VPAHDQRDFE
360 370 380 390 400
FAKKYDLPIR IVIMPEGDEL TEENLEKAYI GEGVLVNSGE FTGLDNQTAI
410 420 430 440 450
REVSQWLEDK KIGKVVTQYK LRDWLISRQR YWGAPIPVVY CEKCGVVPVP
460 470 480 490 500
EKDLPVKLPR DVAFEPTGKS PLIDHPDFKE TTCPKCGGKA KREVDTMDTF
510 520 530 540 550
VDSSWYYLRY VNPKLEDKPF NKEDVDNWLP VDQYIGGVEH AILHLLYSRF
560 570 580 590 600
ITKVLKDLGY VSFDEPFKNL FTQGMIYRNG AKMSKSKGNV VSPEEMIEKY
610 620 630 640 650
GTDALRTYIL FMAPPERDAE WNDSGIEGTY RFLNKVWNTY MKIQDKIIHL
660 670 680 690 700
ENKPNYPLKN KSEKDLRRKL HQTIEKITSD IEGNFQFNTA VSSLMELLNE
710 720 730 740 750
LNSYLNNTDD KDWNLNLLKE FSEDFVLMLS PIAPHISEEL WKNFGKDEFI
760 770 780 790 800
FKASWPEIDK NALKAEEITL AVQINGKLRA QITVDVSLNE DEVKSYALED
810 820
DKVQKYISGK KIQKIIYVPK KIINIVVK
Length:828
Mass (Da):96,100
Last modified:January 15, 2008 - v1
Checksum:iF65300E294F9C3E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000879 Genomic DNA. Translation: ABX31086.1.
RefSeqiYP_001567409.1. NC_010003.1.

Genome annotation databases

EnsemblBacteriaiABX31086; ABX31086; Pmob_0344.
GeneIDi5758364.
KEGGipmo:Pmob_0344.
PATRICi22918226. VBIPetMob40494_0360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000879 Genomic DNA. Translation: ABX31086.1 .
RefSeqi YP_001567409.1. NC_010003.1.

3D structure databases

ProteinModelPortali A9BF22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 403833.Pmob_0344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX31086 ; ABX31086 ; Pmob_0344 .
GeneIDi 5758364.
KEGGi pmo:Pmob_0344.
PATRICi 22918226. VBIPetMob40494_0360.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMOB403833:GH51-352-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10674 / SJ95.

Entry informationi

Entry nameiSYL_PETMO
AccessioniPrimary (citable) accession number: A9BF22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3