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A9BEJ4 (A9BEJ4_PROM4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP MF_00219
Short name=DHOase HAMAP MF_00219
EC=3.5.2.3 HAMAP MF_00219
Gene names
Name:pyrC HAMAP MF_00219
Ordered Locus Names:P9211_05731
OrganismProchlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP] EMBL ABX08504.1
Taxonomic identifier93059 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219 SAAS SAAS004721

Subunit structure

Homodimer By similarity. HAMAP MF_00219 SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP MF_00219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding171Zinc 1 By similarity HAMAP MF_00219
Metal binding191Zinc 1 By similarity HAMAP MF_00219
Metal binding1031Zinc 1; via carbamate group By similarity HAMAP MF_00219
Metal binding1031Zinc 2; via carbamate group By similarity HAMAP MF_00219
Metal binding1401Zinc 2 By similarity HAMAP MF_00219
Metal binding1781Zinc 2 By similarity HAMAP MF_00219
Metal binding2511Zinc 1 By similarity HAMAP MF_00219

Amino acid modifications

Modified residue1031N6-carboxylysine By similarity HAMAP MF_00219

Sequences

Sequence LengthMass (Da)Tools
A9BEJ4 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: CB5435FCA44C45F8

FASTA35739,939
        10         20         30         40         50         60 
MNLSQHQITF RQPDDWHLHL RDDELLNAVV VPSARVFKRA VVMPNLSPPI TSIKSAIEYK 

        70         80         90        100        110        120 
SRILKALPKD YAFTPLMTAY LTDETSPDVL REGFQEGVFF AAKLYPANST TNAAHGVSDI 

       130        140        150        160        170        180 
SKINSTLEMM ERVGIPLLIH GEVTDSDIDI FDREAVFIER CLDPLLRRFP RLTVVLEHIT 

       190        200        210        220        230        240 
TEDAVEYVKT SSAKLGATIT PHHLHINRNA MFQGGIRSDF YCLPIVKRER HRLALRRAVT 

       250        260        270        280        290        300 
SGEPCFFLGT DSAPHLRSSK ESSCGCAGIF NALNAIESYA EVFEQEGAIE KLEAFASEFG 

       310        320        330        340        350 
PAFYGLPLNQ TSITLKKNAH IVPIRFNLNS SFSKNEYLVP FHAGESLSWS ISSPKEN

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000878 Genomic DNA. Translation: ABX08504.1.
RefSeqYP_001550458.1. NC_009976.1.

3D structure databases

ProteinModelPortalA9BEJ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9BEJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5730801.
GenomeReviewsGene locus P9211_05731 in contig CP000878_GR.
KEGGpmj:P9211_05731.
PATRIC22986640. VBIProMar136502_0603.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBA9BEJ4.
ProtClustDBPRK05451.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9BEJ4_PROM4
AccessionPrimary (citable) accession number: A9BEJ4
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info