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A9BEA5

- GSA_PROM4

UniProt

A9BEA5 - GSA_PROM4

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPMAR93059:GHJV-503-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:P9211_04841
    OrganismiProchlorococcus marinus (strain MIT 9211)
    Taxonomic identifieri93059 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000000788: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000121908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei271 – 2711N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA9BEA5.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi93059.P9211_04841.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BEA5.
    SMRiA9BEA5. Positions 5-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiACILMEL.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BEA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNAFNTNLS QAVFNAAQDL MPGGVSSPVR AFKSVNGDPI VFDRVKGPYA    50
    WDLDGNRFID YVGSWGPAIC GHSHPEVIAA LQEALEKGTS FGAPCELENK 100
    LAGMVIEAVP SVEMVRFVNS GTEACMAVLR LMRAFTGRDK LIKFEGCYHG 150
    HADMFLVKAG SGVATLGLPD SPGVPRSTTS NTLTAPYNDL EAVKALFAEN 200
    PDAISGVILE PIVGNAGFIP PEPGFLEGLR ELTKENGSLL VFDEVMTGFR 250
    ISYGGAQERF GVTPDLTTMG KVIGGGLPVG AYGGRKEIMS MVAPAGPMYQ 300
    AGTLSGNPLA MTAGIKTLEL LKQEGTYERL ESLSQRLING ICESAKKAGI 350
    PITGSFISGM FGFYLCEGPV RNFQEAKQTN AELFGKLHRA MLEKGIYLAP 400
    SAFEAGFTSL AHSNDDIETT IKAFEASFSE IV 432
    Length:432
    Mass (Da):45,991
    Last modified:January 15, 2008 - v1
    Checksum:i68892D14BE0F3232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX08415.1.
    RefSeqiWP_012195038.1. NC_009976.1.
    YP_001550369.1. NC_009976.1.

    Genome annotation databases

    EnsemblBacteriaiABX08415; ABX08415; P9211_04841.
    GeneIDi5730581.
    KEGGipmj:P9211_04841.
    PATRICi22986462. VBIProMar136502_0514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX08415.1 .
    RefSeqi WP_012195038.1. NC_009976.1.
    YP_001550369.1. NC_009976.1.

    3D structure databases

    ProteinModelPortali A9BEA5.
    SMRi A9BEA5. Positions 5-431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93059.P9211_04841.

    Proteomic databases

    PRIDEi A9BEA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX08415 ; ABX08415 ; P9211_04841 .
    GeneIDi 5730581.
    KEGGi pmj:P9211_04841.
    PATRICi 22986462. VBIProMar136502_0514.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi ACILMEL.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci PMAR93059:GHJV-503-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9211.

    Entry informationi

    Entry nameiGSA_PROM4
    AccessioniPrimary (citable) accession number: A9BEA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3