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A9BEA5 (GSA_PROM4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:P9211_04841
OrganismProchlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP]
Taxonomic identifier93059 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processChlorophyll biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processchlorophyll biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate-1-semialdehyde 2,1-aminomutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

transaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_1000121908

Amino acid modifications

Modified residue2711N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A9BEA5 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 68892D14BE0F3232

FASTA43245,991
        10         20         30         40         50         60 
MTNAFNTNLS QAVFNAAQDL MPGGVSSPVR AFKSVNGDPI VFDRVKGPYA WDLDGNRFID 

        70         80         90        100        110        120 
YVGSWGPAIC GHSHPEVIAA LQEALEKGTS FGAPCELENK LAGMVIEAVP SVEMVRFVNS 

       130        140        150        160        170        180 
GTEACMAVLR LMRAFTGRDK LIKFEGCYHG HADMFLVKAG SGVATLGLPD SPGVPRSTTS 

       190        200        210        220        230        240 
NTLTAPYNDL EAVKALFAEN PDAISGVILE PIVGNAGFIP PEPGFLEGLR ELTKENGSLL 

       250        260        270        280        290        300 
VFDEVMTGFR ISYGGAQERF GVTPDLTTMG KVIGGGLPVG AYGGRKEIMS MVAPAGPMYQ 

       310        320        330        340        350        360 
AGTLSGNPLA MTAGIKTLEL LKQEGTYERL ESLSQRLING ICESAKKAGI PITGSFISGM 

       370        380        390        400        410        420 
FGFYLCEGPV RNFQEAKQTN AELFGKLHRA MLEKGIYLAP SAFEAGFTSL AHSNDDIETT 

       430 
IKAFEASFSE IV 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9211.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000878 Genomic DNA. Translation: ABX08415.1.
RefSeqYP_001550369.1. NC_009976.1.

3D structure databases

ProteinModelPortalA9BEA5.
SMRA9BEA5. Positions 5-431.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93059.P9211_04841.

Proteomic databases

PRIDEA9BEA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX08415; ABX08415; P9211_04841.
GeneID5730581.
KEGGpmj:P9211_04841.
PATRIC22986462. VBIProMar136502_0514.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0001.
HOGENOMHOG000020210.
KOK01845.
OMAACILMEL.
OrthoDBEOG6QVRHN.

Enzyme and pathway databases

BioCycPMAR93059:GHJV-503-MONOMER.
UniPathwayUPA00251; UER00317.
UPA00668.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_PROM4
AccessionPrimary (citable) accession number: A9BEA5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways