A9BE04 (AROQ_PROM4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	P9211_03831

Organism

Prochlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP]

Taxonomic identifier

93059 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus › Prochlorococcus marinus

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169
Subunit structure	Homododecamer By similarity. HAMAP-Rule MF_00169
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	3-dehydroquinate dehydratase HAMAP-Rule MF_00169		PRO_1000097614
Regions
	Region	100 – 101	2	Substrate binding By similarity
Sites
	Active site	22	1	Proton acceptor By similarity
	Active site	99	1	Proton donor By similarity
	Binding site	73	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	86	1	Substrate By similarity
	Binding site	110	1	Substrate By similarity
	Site	17	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9BE04 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 1FCE8A56DABCBC6C	FASTA	148	16,307
	10 20 30 40 50 60 MNLLLLNGPN LNLLGKREPS IYGSQSLESI EISLSQRAKE EGVGLECFQS NSEGTLVDYI 70 80 90 100 110 120 HQSIGKVDAI LINAGAYTHT SIALRDALLS AEIPYVELHL SNTYARETFR QKSLLADRAI 130 140 GVVSGFGVMS YQLAFQGILD YLRNRSKE

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9211.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000878 Genomic DNA. Translation: ABX08314.1.
RefSeq	YP_001550268.1. NC_009976.1.
3D structure databases
ProteinModelPortal	A9BE04.
SMR	A9BE04. Positions 2-143.
ModBase	Search...
Protein-protein interaction databases
STRING	93059.P9211_03831.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX08314; ABX08314; P9211_03831.
GeneID	5730128.
KEGG	pmj:P9211_03831.
PATRIC	22986246. VBIProMar136502_0408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0757.
HOGENOM	HOG000217278.
KO	K03786.
OMA	THYGLAL.
ProtClustDB	PRK05395.
Enzyme and pathway databases
BioCyc	PMAR93059:GHJV-400-MONOMER.
UniPathway	UPA00053; UER00086.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_PROM4

Accession

Primary (citable) accession number: A9BE04

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program