A9BBT1 (A9BBT1_PROM4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 3 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 3 HAMAP MF_00444

Gene names

Name:	clpP3 HAMAP MF_00444
Ordered Locus Names:	P9211_13621

Organism

Prochlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP] EMBL ABX09293.1

Taxonomic identifier

93059 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	124	1	By similarity HAMAP MF_00444
	Active site	149	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A9BBT1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 2FAF58CD61523B64	FASTA	223	24,826
	10 20 30 40 50 60 MRSNVALKLL KPLSYHLSKT FFIMPIGTPS VPYRLPGSQF ERWVDIYTRL GAERILFLGQ 70 80 90 100 110 120 EVNDGVANSL VAQMLYLDSE DSTKPIYLYI NSPGGSVTAG LAIYDTMKYV KSDVVTICVG 130 140 150 160 170 180 LAASMGAFLL SAGTKNKRLA LPHSRIMIHQ PLGGTSQRQA SDIEIEAKEI LRIKEMLNRS 190 200 210 220 LAEMTGQSFE KIEKDTDRDY FLSAKEAEEY GLIDKVICHP NEA

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000878 Genomic DNA. Translation: ABX09293.1.
RefSeq	YP_001551247.1. NC_009976.1.
3D structure databases
ProteinModelPortal	A9BBT1.
SMR	A9BBT1. Positions 45-217.
ModBase	Search...
Protein-protein interaction databases
STRING	A9BBT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5730745.
GenomeReviews	Gene locus P9211_13621 in contig CP000878_GR.
KEGG	pmj:P9211_13621.
PATRIC	22988336. VBIProMar136502_1437.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG558421.
OMA	DGVANSL.
PhylomeDB	A9BBT1.
ProtClustDB	PRK00277.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9BBT1_PROM4

Accession

Primary (citable) accession number: A9BBT1

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)