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A9BBJ7

- PNP_PROM4

UniProt

A9BBJ7 - PNP_PROM4

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi495 – 4951MagnesiumUniRule annotation
    Metal bindingi501 – 5011MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciPMAR93059:GHJV-1306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:P9211_12781
    OrganismiProchlorococcus marinus (strain MIT 9211)
    Taxonomic identifieri93059 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000000788: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 722722Polyribonucleotide nucleotidyltransferasePRO_1000192483Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93059.P9211_12781.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BBJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini562 – 62160KHUniRule annotationAdd
    BLAST
    Domaini631 – 69969S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiILDHMEQ.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BBJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGQTTTVSF DGREIRLTTG RYAPQAGGSV LIECGDTAVL VTATQSPGRE    50
    GADFLPLICD YEERLYAAGR IPGSFMRREG RPPERATLIS RLIDRPLRPL 100
    FPSWMRDDIQ VVATCLSLDE RVPSDVLAVT ASSMATLLAE IPFYGPMAAV 150
    RVGLLGDDFV LNPSFREIER GDLDLVVAGT PDGVVMIEAG ANQLSEQDVI 200
    EAVDFGYEAV TELIKAQQSI LKESGIDHKK PDEQEIDETL PNYLDKNGRK 250
    PIGELLKKFE LTKKERDLKL EEIKTNLGEK IDSLKEDNAV KKAISSNPKL 300
    LTTSFKSLTK KLMREQIIKD GKRVDGRALD EVRKIEAAAG ILPKRVHGSG 350
    LFQRGLTQVL STATLGTPSD AQEMDDLNPS SDKTYIHHYN FPPYSVGETR 400
    PMRTPGRREV GHGALAERAL IPVLPPKESF PYVLRVVSEV LSSNGSTSMG 450
    SVCGSTIALL DAGVPLKAPV SGAAMGLIKE GKEIRILTDI QGIEDFLGDM 500
    DFKVAGTEKG ITALQMDMKV TGLEVKTIAD AINQAKPART HILEKMNETI 550
    DKPRETLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED 600
    GGIVTIASHD GVAAEEAQKI IEGLTRKVHE GEIFTGSITR IIPIGAFVEI 650
    LPGKEGMIHI SQLSEARVEK VEDVVKVGDE VTVRVREIDN RGRINLTLRG 700
    VSQNNNDMNY PQPTPTPVAP LN 722
    Length:722
    Mass (Da):78,704
    Last modified:January 15, 2008 - v1
    Checksum:i8DC82E0D08C7DC23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX09209.1.
    RefSeqiYP_001551163.1. NC_009976.1.

    Genome annotation databases

    EnsemblBacteriaiABX09209; ABX09209; P9211_12781.
    GeneIDi5731484.
    KEGGipmj:P9211_12781.
    PATRICi22988160. VBIProMar136502_1354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX09209.1 .
    RefSeqi YP_001551163.1. NC_009976.1.

    3D structure databases

    ProteinModelPortali A9BBJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93059.P9211_12781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX09209 ; ABX09209 ; P9211_12781 .
    GeneIDi 5731484.
    KEGGi pmj:P9211_12781.
    PATRICi 22988160. VBIProMar136502_1354.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi ILDHMEQ.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci PMAR93059:GHJV-1306-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9211.

    Entry informationi

    Entry nameiPNP_PROM4
    AccessioniPrimary (citable) accession number: A9BBJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3