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A9BAE4

- SYL_PROM4

UniProt

A9BAE4 - SYL_PROM4

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Protein
Leucine--tRNA ligase
Gene
leuS, P9211_08751
Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93059:GHJV-900-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:P9211_08751
OrganismiProchlorococcus marinus (strain MIT 9211)
Taxonomic identifieri93059 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000000788: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Leucine--tRNA ligaseUniRule annotation
PRO_1000091345Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93059.P9211_08751.

Structurei

3D structure databases

ProteinModelPortaliA9BAE4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi56 – 6611"HIGH" regionUniRule annotation
Add
BLAST
Motifi629 – 6335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9BAE4-1 [UniParc]FASTAAdd to Basket

« Hide

MTDTSSSISR KSLRADSYQP QLIEEKWQNE WKISGLYKTR EPKEDQKTFY    50
ALSMFPYPSG NLHMGHVRNY VITDVIARVH RMKGFSVLHP MGWDAFGLPA 100
ENAAIERNIQ PDIWTEKNIS HMRSQLDRLG LSIDWDREQT TSKSEYYKWT 150
QSIFLKLYEA GLAYQKSATV NWDPVDKTVL ANEQVDADGK SWRSGALVEK 200
KQLKQWFLKI TDYAEILLKD IDTLTEWPER VKTMQSNWIG KSVGVKINFQ 250
LLTKEKENLS VFTTRPDTLF GSTYLVLSPE DKLVDKLVDP KLINDLSNFR 300
DYVSKLSDKE RTAEGKPKNG MAIGAYAINP INQEKLPIWI ADYVLSGYGT 350
GAVMGVPAHD QRDLDFAQKY SLPIKYVIKP SGIIEKKKEV KAYSEVGVMI 400
NSGPFNGQKS DEVKSLITEK GIKENWAEKK TTYKLRDWLI SRQRYWGCPI 450
PIVHCAKCGI VPIEKENLPV FLPTNIQLSG KGNSPLKDNE WTKTQCPICK 500
GIARRESDTM DTFICSSWYY LRFIDPNNKK NIIDKNLADR WMPVDQYVGG 550
IEHAILHLLY ARFITKVLRD KDMISIDEPF KKLLTQGMVQ GITFKNPKTG 600
KYIPPNKINN IKTPLDPSTG ESLELIYEKM SKSKHNGIDP STVIDKYGAD 650
TARMFILFKA PPEKDLEWDD ADVEGQYRFL QRLWRLINES KTYNKLSLDS 700
NENNNLNNLN QDEISLRRSV HLAIKEISND LNEGNQFNTA ISELMKLSNN 750
MNELLGKCRI SVVNESLSIL IRILSPFAPH LAEEAWSTLK GKGSVHEQKW 800
PEFDPNALKQ DNYQLVIQMN GKVRGSIKIA SETNKQEIEK IALNSDIAKK 850
WLIDGSYKKV IVVLGKLVNI VY 872
Length:872
Mass (Da):99,820
Last modified:January 15, 2008 - v1
Checksum:iCBE15658902CED49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000878 Genomic DNA. Translation: ABX08806.1.
RefSeqiWP_012195428.1. NC_009976.1.
YP_001550760.1. NC_009976.1.

Genome annotation databases

EnsemblBacteriaiABX08806; ABX08806; P9211_08751.
GeneIDi5730352.
KEGGipmj:P9211_08751.
PATRICi22987310. VBIProMar136502_0933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000878 Genomic DNA. Translation: ABX08806.1 .
RefSeqi WP_012195428.1. NC_009976.1.
YP_001550760.1. NC_009976.1.

3D structure databases

ProteinModelPortali A9BAE4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 93059.P9211_08751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX08806 ; ABX08806 ; P9211_08751 .
GeneIDi 5730352.
KEGGi pmj:P9211_08751.
PATRICi 22987310. VBIProMar136502_0933.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR93059:GHJV-900-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9211.

Entry informationi

Entry nameiSYL_PROM4
AccessioniPrimary (citable) accession number: A9BAE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi