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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei632ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:P9211_08751
OrganismiProchlorococcus marinus (strain MIT 9211)
Taxonomic identifieri93059 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000000788 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913451 – 872Leucine--tRNA ligaseAdd BLAST872

Proteomic databases

PRIDEiA9BAE4

Interactioni

Protein-protein interaction databases

STRINGi93059.P9211_08751

Structurei

3D structure databases

ProteinModelPortaliA9BAE4
SMRiA9BAE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi56 – 66"HIGH" regionAdd BLAST11
Motifi629 – 633"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9BAE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSSSISR KSLRADSYQP QLIEEKWQNE WKISGLYKTR EPKEDQKTFY
60 70 80 90 100
ALSMFPYPSG NLHMGHVRNY VITDVIARVH RMKGFSVLHP MGWDAFGLPA
110 120 130 140 150
ENAAIERNIQ PDIWTEKNIS HMRSQLDRLG LSIDWDREQT TSKSEYYKWT
160 170 180 190 200
QSIFLKLYEA GLAYQKSATV NWDPVDKTVL ANEQVDADGK SWRSGALVEK
210 220 230 240 250
KQLKQWFLKI TDYAEILLKD IDTLTEWPER VKTMQSNWIG KSVGVKINFQ
260 270 280 290 300
LLTKEKENLS VFTTRPDTLF GSTYLVLSPE DKLVDKLVDP KLINDLSNFR
310 320 330 340 350
DYVSKLSDKE RTAEGKPKNG MAIGAYAINP INQEKLPIWI ADYVLSGYGT
360 370 380 390 400
GAVMGVPAHD QRDLDFAQKY SLPIKYVIKP SGIIEKKKEV KAYSEVGVMI
410 420 430 440 450
NSGPFNGQKS DEVKSLITEK GIKENWAEKK TTYKLRDWLI SRQRYWGCPI
460 470 480 490 500
PIVHCAKCGI VPIEKENLPV FLPTNIQLSG KGNSPLKDNE WTKTQCPICK
510 520 530 540 550
GIARRESDTM DTFICSSWYY LRFIDPNNKK NIIDKNLADR WMPVDQYVGG
560 570 580 590 600
IEHAILHLLY ARFITKVLRD KDMISIDEPF KKLLTQGMVQ GITFKNPKTG
610 620 630 640 650
KYIPPNKINN IKTPLDPSTG ESLELIYEKM SKSKHNGIDP STVIDKYGAD
660 670 680 690 700
TARMFILFKA PPEKDLEWDD ADVEGQYRFL QRLWRLINES KTYNKLSLDS
710 720 730 740 750
NENNNLNNLN QDEISLRRSV HLAIKEISND LNEGNQFNTA ISELMKLSNN
760 770 780 790 800
MNELLGKCRI SVVNESLSIL IRILSPFAPH LAEEAWSTLK GKGSVHEQKW
810 820 830 840 850
PEFDPNALKQ DNYQLVIQMN GKVRGSIKIA SETNKQEIEK IALNSDIAKK
860 870
WLIDGSYKKV IVVLGKLVNI VY
Length:872
Mass (Da):99,820
Last modified:January 15, 2008 - v1
Checksum:iCBE15658902CED49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000878 Genomic DNA Translation: ABX08806.1
RefSeqiWP_012195428.1, NC_009976.1

Genome annotation databases

EnsemblBacteriaiABX08806; ABX08806; P9211_08751
KEGGipmj:P9211_08751

Similar proteinsi

Entry informationi

Entry nameiSYL_PROM4
AccessioniPrimary (citable) accession number: A9BAE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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