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A9BAE4

- SYL_PROM4

UniProt

A9BAE4 - SYL_PROM4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR93059:GHJV-900-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:P9211_08751
    OrganismiProchlorococcus marinus (strain MIT 9211)
    Taxonomic identifieri93059 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000000788: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 872872Leucine--tRNA ligasePRO_1000091345Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93059.P9211_08751.

    Structurei

    3D structure databases

    ProteinModelPortaliA9BAE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi56 – 6611"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVHRQSWP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9BAE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDTSSSISR KSLRADSYQP QLIEEKWQNE WKISGLYKTR EPKEDQKTFY    50
    ALSMFPYPSG NLHMGHVRNY VITDVIARVH RMKGFSVLHP MGWDAFGLPA 100
    ENAAIERNIQ PDIWTEKNIS HMRSQLDRLG LSIDWDREQT TSKSEYYKWT 150
    QSIFLKLYEA GLAYQKSATV NWDPVDKTVL ANEQVDADGK SWRSGALVEK 200
    KQLKQWFLKI TDYAEILLKD IDTLTEWPER VKTMQSNWIG KSVGVKINFQ 250
    LLTKEKENLS VFTTRPDTLF GSTYLVLSPE DKLVDKLVDP KLINDLSNFR 300
    DYVSKLSDKE RTAEGKPKNG MAIGAYAINP INQEKLPIWI ADYVLSGYGT 350
    GAVMGVPAHD QRDLDFAQKY SLPIKYVIKP SGIIEKKKEV KAYSEVGVMI 400
    NSGPFNGQKS DEVKSLITEK GIKENWAEKK TTYKLRDWLI SRQRYWGCPI 450
    PIVHCAKCGI VPIEKENLPV FLPTNIQLSG KGNSPLKDNE WTKTQCPICK 500
    GIARRESDTM DTFICSSWYY LRFIDPNNKK NIIDKNLADR WMPVDQYVGG 550
    IEHAILHLLY ARFITKVLRD KDMISIDEPF KKLLTQGMVQ GITFKNPKTG 600
    KYIPPNKINN IKTPLDPSTG ESLELIYEKM SKSKHNGIDP STVIDKYGAD 650
    TARMFILFKA PPEKDLEWDD ADVEGQYRFL QRLWRLINES KTYNKLSLDS 700
    NENNNLNNLN QDEISLRRSV HLAIKEISND LNEGNQFNTA ISELMKLSNN 750
    MNELLGKCRI SVVNESLSIL IRILSPFAPH LAEEAWSTLK GKGSVHEQKW 800
    PEFDPNALKQ DNYQLVIQMN GKVRGSIKIA SETNKQEIEK IALNSDIAKK 850
    WLIDGSYKKV IVVLGKLVNI VY 872
    Length:872
    Mass (Da):99,820
    Last modified:January 15, 2008 - v1
    Checksum:iCBE15658902CED49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX08806.1.
    RefSeqiWP_012195428.1. NC_009976.1.
    YP_001550760.1. NC_009976.1.

    Genome annotation databases

    EnsemblBacteriaiABX08806; ABX08806; P9211_08751.
    GeneIDi5730352.
    KEGGipmj:P9211_08751.
    PATRICi22987310. VBIProMar136502_0933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000878 Genomic DNA. Translation: ABX08806.1 .
    RefSeqi WP_012195428.1. NC_009976.1.
    YP_001550760.1. NC_009976.1.

    3D structure databases

    ProteinModelPortali A9BAE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93059.P9211_08751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX08806 ; ABX08806 ; P9211_08751 .
    GeneIDi 5730352.
    KEGGi pmj:P9211_08751.
    PATRICi 22987310. VBIProMar136502_0933.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VHRQSWP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMAR93059:GHJV-900-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9211.

    Entry informationi

    Entry nameiSYL_PROM4
    AccessioniPrimary (citable) accession number: A9BAE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3