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A9BAE4

- SYL_PROM4

UniProt

A9BAE4 - SYL_PROM4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9211)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR93059:GHJV-900-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:P9211_08751
OrganismiProchlorococcus marinus (strain MIT 9211)
Taxonomic identifieri93059 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000000788: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 872872Leucine--tRNA ligasePRO_1000091345Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93059.P9211_08751.

Structurei

3D structure databases

ProteinModelPortaliA9BAE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi56 – 6611"HIGH" regionAdd
BLAST
Motifi629 – 6335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9BAE4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDTSSSISR KSLRADSYQP QLIEEKWQNE WKISGLYKTR EPKEDQKTFY
60 70 80 90 100
ALSMFPYPSG NLHMGHVRNY VITDVIARVH RMKGFSVLHP MGWDAFGLPA
110 120 130 140 150
ENAAIERNIQ PDIWTEKNIS HMRSQLDRLG LSIDWDREQT TSKSEYYKWT
160 170 180 190 200
QSIFLKLYEA GLAYQKSATV NWDPVDKTVL ANEQVDADGK SWRSGALVEK
210 220 230 240 250
KQLKQWFLKI TDYAEILLKD IDTLTEWPER VKTMQSNWIG KSVGVKINFQ
260 270 280 290 300
LLTKEKENLS VFTTRPDTLF GSTYLVLSPE DKLVDKLVDP KLINDLSNFR
310 320 330 340 350
DYVSKLSDKE RTAEGKPKNG MAIGAYAINP INQEKLPIWI ADYVLSGYGT
360 370 380 390 400
GAVMGVPAHD QRDLDFAQKY SLPIKYVIKP SGIIEKKKEV KAYSEVGVMI
410 420 430 440 450
NSGPFNGQKS DEVKSLITEK GIKENWAEKK TTYKLRDWLI SRQRYWGCPI
460 470 480 490 500
PIVHCAKCGI VPIEKENLPV FLPTNIQLSG KGNSPLKDNE WTKTQCPICK
510 520 530 540 550
GIARRESDTM DTFICSSWYY LRFIDPNNKK NIIDKNLADR WMPVDQYVGG
560 570 580 590 600
IEHAILHLLY ARFITKVLRD KDMISIDEPF KKLLTQGMVQ GITFKNPKTG
610 620 630 640 650
KYIPPNKINN IKTPLDPSTG ESLELIYEKM SKSKHNGIDP STVIDKYGAD
660 670 680 690 700
TARMFILFKA PPEKDLEWDD ADVEGQYRFL QRLWRLINES KTYNKLSLDS
710 720 730 740 750
NENNNLNNLN QDEISLRRSV HLAIKEISND LNEGNQFNTA ISELMKLSNN
760 770 780 790 800
MNELLGKCRI SVVNESLSIL IRILSPFAPH LAEEAWSTLK GKGSVHEQKW
810 820 830 840 850
PEFDPNALKQ DNYQLVIQMN GKVRGSIKIA SETNKQEIEK IALNSDIAKK
860 870
WLIDGSYKKV IVVLGKLVNI VY
Length:872
Mass (Da):99,820
Last modified:January 15, 2008 - v1
Checksum:iCBE15658902CED49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000878 Genomic DNA. Translation: ABX08806.1.
RefSeqiWP_012195428.1. NC_009976.1.
YP_001550760.1. NC_009976.1.

Genome annotation databases

EnsemblBacteriaiABX08806; ABX08806; P9211_08751.
GeneIDi5730352.
KEGGipmj:P9211_08751.
PATRICi22987310. VBIProMar136502_0933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000878 Genomic DNA. Translation: ABX08806.1 .
RefSeqi WP_012195428.1. NC_009976.1.
YP_001550760.1. NC_009976.1.

3D structure databases

ProteinModelPortali A9BAE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93059.P9211_08751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX08806 ; ABX08806 ; P9211_08751 .
GeneIDi 5730352.
KEGGi pmj:P9211_08751.
PATRICi 22987310. VBIProMar136502_0933.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR93059:GHJV-900-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9211.

Entry informationi

Entry nameiSYL_PROM4
AccessioniPrimary (citable) accession number: A9BAE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3