A9BAE1 (ARGC_PROM4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	P9211_08721

Organism

Prochlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP]

Taxonomic identifier

93059 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096735
Sites
	Active site	162	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9BAE1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: CB0DF6955332F201	FASTA	359	39,761
	10 20 30 40 50 60 MSLSNNNSNR VAIIGASGYG GLQLMRLLSD HPHFKVTFLG GNKTAGNKWH QIAPFIKSSE 70 80 90 100 110 120 DLTVRKADPE DIAEHADFAL LSLPNGLSSQ LTPELIKRNI RIVDLSADYR YRSLYQWKQV 130 140 150 160 170 180 YVKESTKYIR NDDSLCREAT YGIPEWNEGD IRKSKLVACP GCFPTASLLP LMPFLKQGLV 190 200 210 220 230 240 ENEGLIIDAK SGTSGGGREP KEHLLLSECS ESIAPYSVLG HRHTSEIEQQ ATLVSGTPIQ 250 260 270 280 290 300 LQFTPHLVPM VRGLLSTVYA RLRDPGLTAE DCKTVLEAFY RSHSTVEILP VGIYPSTKWA 310 320 330 340 350 RYTNKALLSL QVDKRNGRLI LVSVIDNLIK GQAGQAIQNL NIMAGFSHEL GLPLTTFYP

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9211.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000878 Genomic DNA. Translation: ABX08803.1.
RefSeq	YP_001550757.1. NC_009976.1.
3D structure databases
ProteinModelPortal	A9BAE1.
ModBase	Search...
Protein-protein interaction databases
STRING	A9BAE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5730755.
GenomeReviews	Gene locus P9211_08721 in contig CP000878_GR.
KEGG	pmj:P9211_08721.
PATRIC	22987304. VBIProMar136502_0930.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	A9BAE1.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_PROM4

Accession

Primary (citable) accession number: A9BAE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program