A9B9Y1 (A9B9Y1_PROM4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
Short name=CMK HAMAP MF_00061
EC=2.7.1.148 HAMAP MF_00061

Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP MF_00061

Gene names

Name:	ispE HAMAP MF_00061
Ordered Locus Names:	P9211_07121

Organism

Prochlorococcus marinus (strain MIT 9211) [Complete proteome] [HAMAP] EMBL ABX08643.1

Taxonomic identifier

93059 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061
Catalytic activity	ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061
Sequence similarities	Belongs to the GHMP kinase family. IspE subfamily. HAMAP MF_00061

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00061
Ligand	ATP-binding HAMAP MF_00061 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00061 EMBL ABX08643.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	104 – 114	11	ATP By similarity HAMAP MF_00061
Sites
	Active site	19	1	By similarity HAMAP MF_00061
	Active site	146	1	By similarity HAMAP MF_00061

Sequences

	Sequence		Length	Mass (Da)
	A9B9Y1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: B7C3B0608DC6C762	FASTA	317	34,369
	10 20 30 40 50 60 MNKVSSSIAE SLKVYASAKI NLHLEVLGLR KDGFHELAMV MQSIDLVDEI EITKTNDELI 70 80 90 100 110 120 SLNSDNPELD NGDGNLIIKA AKLIRSRSGL RDLGALIYLR KKIPIGAGLA GGSSDGAATL 130 140 150 160 170 180 VGLNSLWGLN FSNNQLEDMA AELGSDVPFC ISGGAQLCFG RGECLEPLDK SDPTLAIVLV 190 200 210 220 230 240 KDPSVSVSTP WAYSRYKQLN ESTYLSKEID FQEKRMALRK ASWLRPLNAS NPPPLINDLQ 250 260 270 280 290 300 EVVAPATPAV EKALQFLRSL KGVLSVAMSG SGPSCFAIFS DLDQARIALE ENQEELRKQC 310 LEGWCCALNS KGVRFAK

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000878 Genomic DNA. Translation: ABX08643.1.
RefSeq	YP_001550597.1. NC_009976.1.
3D structure databases
ProteinModelPortal	A9B9Y1.
ModBase	Search...
Protein-protein interaction databases
STRING	A9B9Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5731093.
GenomeReviews	Gene locus P9211_07121 in contig CP000878_GR.
KEGG	pmj:P9211_07121.
PATRIC	22986964. VBIProMar136502_0762.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734593.
OMA	QLCFGRG.
PhylomeDB	A9B9Y1.
ProtClustDB	PRK02534.
Family and domain databases
HAMAP	MF_00061. IspE. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00919.
PANTHER	PTHR20861:SF2. IspE. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF010376. IspE. 1 hit.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00154. IspE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9B9Y1_PROM4

Accession

Primary (citable) accession number: A9B9Y1

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)