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A9B8G1

- PNP_HERA2

UniProt

A9B8G1 - PNP_HERA2

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi494 – 4941MagnesiumUniRule annotation
Metal bindingi500 – 5001MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciHAUR316274:GHYA-3922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Haur_3880
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
ProteomesiUP000000787: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Polyribonucleotide nucleotidyltransferasePRO_0000381905Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316274.Haur_3880.

Structurei

3D structure databases

ProteinModelPortaliA9B8G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 62060KHUniRule annotationAdd
BLAST
Domaini630 – 69970S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9B8G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQQVHSVT VELAGRPLTI EAGRVAQLAN GAVLVRYGDT VLLAAVTASA
60 70 80 90 100
EPRDGIDFFP LTVDYEEKMY AAGKIPGSFF KREGRPTETA ILTSRLTDRP
110 120 130 140 150
LRPLFPKGYY NDVQVSITTL STDQVNDPGP LAIIGASAAL VISDIPFAAP
160 170 180 190 200
VGAVQMGHID GVFAVNPVMG LMENSRLDLV VAGTSEAVMM VEASAYELTE
210 220 230 240 250
AEMLEAVKRG HEAMQAVIQA QLELAEKCGK PKKEFVAPVV DTSLQDEIKA
260 270 280 290 300
WMGNRFLQAL NNSDKAAREA ATDSLRTDVL EQFSAGVAEE ELAARVKAVT
310 320 330 340 350
KNYDALVKDE VRASILEQGI RVDGRKVNEI RPIAVDVGVL PRVHGSGLFT
360 370 380 390 400
RGQTQVLTVA TLGSPGDEQR LDDLGIETTR HYMHHYNFPA FSTGEARPSR
410 420 430 440 450
GPRRRDIGHG KLAERALVPV LPEKDKFPYT MRLVSEVLAS NGSSSMASVC
460 470 480 490 500
GSSLALMDAG VPIKAPVAGV AMGLITGKEA GQFSVLTDIQ GLEDALGDMD
510 520 530 540 550
FKVAGTTAGI TALQMDIKTT GITYEIMQQA FEQARQGRVF ILDKMNEIIN
560 570 580 590 600
TARNDISQFA PRIITLQIDP SKIGALIGPG GKTIRSIIEQ TGAQIDVEDD
610 620 630 640 650
GRVFVTTPDA DGARMAQSLI EGLTREAKVG EIFTGKVVRI MPYGAFVNVL
660 670 680 690 700
PGKDGMVHVS ELDEKRVENV EDVVKIGDEL TVMVIDVEPG TGKLSLSRRA
710 720 730 740 750
ILTGETAEQR KSSSSKGGPR GGGGGGDRGP RPGGDRGPRP EGDRGPRPEG
760 770
DRPREGGDRG PRPGNGGNDR RGGGFRG
Length:777
Mass (Da):83,008
Last modified:January 15, 2008 - v1
Checksum:i59DB37C4C8CDC59B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX06514.1.
RefSeqiYP_001546642.1. NC_009972.1.

Genome annotation databases

EnsemblBacteriaiABX06514; ABX06514; Haur_3880.
GeneIDi5735729.
KEGGihau:Haur_3880.
PATRICi22124953. VBIHerAur93466_3992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX06514.1 .
RefSeqi YP_001546642.1. NC_009972.1.

3D structure databases

ProteinModelPortali A9B8G1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316274.Haur_3880.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX06514 ; ABX06514 ; Haur_3880 .
GeneIDi 5735729.
KEGGi hau:Haur_3880.
PATRICi 22124953. VBIHerAur93466_3992.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci HAUR316274:GHYA-3922-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Bryant D.A., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23779 / DSM 785.

Entry informationi

Entry nameiPNP_HERA2
AccessioniPrimary (citable) accession number: A9B8G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3