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A9B5H8 (LEXA_HERA2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LexA repressor

EC=3.4.21.88
Gene names
Name:lexA
Ordered Locus Names:Haur_0151
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteriaChloroflexiHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP-Rule MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor LexA. HAMAP-Rule MF_00015

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214LexA repressor HAMAP-Rule MF_00015
PRO_1000089569

Regions

DNA binding28 – 4821H-T-H motif By similarity

Sites

Active site1331For autocatalytic cleavage activity By similarity
Active site1721For autocatalytic cleavage activity By similarity
Site92 – 932Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
A9B5H8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 9C6A4B188CB92E14

FASTA21423,653
        10         20         30         40         50         60 
MSGLSQRQQR IYDYIKQFIR TNGYAPAIRD IQRELSISST SVVAYNLRAL ESKGHIRREG 

        70         80         90        100        110        120 
NISRAIELIN AEQPLPTVLG GQRVPVLGVI AAGQPIPVPN DSANSDDSVL VPEEIVGNDK 

       130        140        150        160        170        180 
LGDVYALRVK GYSMVDALIA DGDIVLLRYQ ATAENGEMVA ARIRDENEVT LKRIYWEGDR 

       190        200        210 
VRLQPANVTM EAMYYPSTNV EVQGRVVGVI RNLG 

« Hide

References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000875 Genomic DNA. Translation: ABX02803.1.
RefSeqYP_001542931.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9B5H8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316274.Haur_0151.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX02803; ABX02803; Haur_0151.
GeneID5732060.
KEGGhau:Haur_0151.
PATRIC22117191. VBIHerAur93466_0151.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHOG000232168.
KOK01356.
OMAQNTANNG.
OrthoDBEOG6JHRHJ.
ProtClustDBCLSK935549.

Enzyme and pathway databases

BioCycHAUR316274:GHYA-154-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPMF_00015. LexA.
InterProIPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. SSF51306. 1 hit.
TIGRFAMsTIGR00498. lexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_HERA2
AccessionPrimary (citable) accession number: A9B5H8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries