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A9B5H8

- LEXA_HERA2

UniProt

A9B5H8 - LEXA_HERA2

Protein

LexA repressor

Gene

lexA

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

    Catalytic activityi

    Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei92 – 932Cleavage; by autolysisUniRule annotation
    Active sitei133 – 1331For autocatalytic cleavage activityUniRule annotation
    Active sitei172 – 1721For autocatalytic cleavage activityUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi28 – 4821H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP
    2. DNA replication Source: UniProtKB-HAMAP
    3. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    4. SOS response Source: UniProtKB-HAMAP
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Repressor

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciHAUR316274:GHYA-154-MONOMER.

    Protein family/group databases

    MEROPSiS24.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
    Gene namesi
    Name:lexAUniRule annotation
    Ordered Locus Names:Haur_0151
    OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
    Taxonomic identifieri316274 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
    ProteomesiUP000000787: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214LexA repressorPRO_1000089569Add
    BLAST

    Keywords - PTMi

    Autocatalytic cleavage

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi316274.Haur_0151.

    Structurei

    3D structure databases

    ProteinModelPortaliA9B5H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S24 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1974.
    HOGENOMiHOG000232168.
    KOiK01356.
    OMAiYIEWTEG.
    OrthoDBiEOG6JHRHJ.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPiMF_00015. LexA.
    InterProiIPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00726. LEXASERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR00498. lexA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9B5H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLSQRQQR IYDYIKQFIR TNGYAPAIRD IQRELSISST SVVAYNLRAL    50
    ESKGHIRREG NISRAIELIN AEQPLPTVLG GQRVPVLGVI AAGQPIPVPN 100
    DSANSDDSVL VPEEIVGNDK LGDVYALRVK GYSMVDALIA DGDIVLLRYQ 150
    ATAENGEMVA ARIRDENEVT LKRIYWEGDR VRLQPANVTM EAMYYPSTNV 200
    EVQGRVVGVI RNLG 214
    Length:214
    Mass (Da):23,653
    Last modified:January 15, 2008 - v1
    Checksum:i9C6A4B188CB92E14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX02803.1.
    RefSeqiWP_012187711.1. NC_009972.1.
    YP_001542931.1. NC_009972.1.

    Genome annotation databases

    EnsemblBacteriaiABX02803; ABX02803; Haur_0151.
    GeneIDi5732060.
    KEGGihau:Haur_0151.
    PATRICi22117191. VBIHerAur93466_0151.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX02803.1 .
    RefSeqi WP_012187711.1. NC_009972.1.
    YP_001542931.1. NC_009972.1.

    3D structure databases

    ProteinModelPortali A9B5H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316274.Haur_0151.

    Protein family/group databases

    MEROPSi S24.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX02803 ; ABX02803 ; Haur_0151 .
    GeneIDi 5732060.
    KEGGi hau:Haur_0151.
    PATRICi 22117191. VBIHerAur93466_0151.

    Phylogenomic databases

    eggNOGi COG1974.
    HOGENOMi HOG000232168.
    KOi K01356.
    OMAi YIEWTEG.
    OrthoDBi EOG6JHRHJ.

    Enzyme and pathway databases

    BioCyci HAUR316274:GHYA-154-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.10.109.10. 1 hit.
    HAMAPi MF_00015. LexA.
    InterProi IPR006200. LexA.
    IPR006199. LexA_DNA-bd_dom.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR006197. Peptidase_S24_LexA.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01726. LexA_DNA_bind. 1 hit.
    PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00726. LEXASERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR00498. lexA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Bryant D.A., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23779 / DSM 785.

    Entry informationi

    Entry nameiLEXA_HERA2
    AccessioniPrimary (citable) accession number: A9B5H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3