A9B549 (A9B549_HERA2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ABX06186.1
EC=4.2.1.24 EMBL ABX06186.1

Gene names

Ordered Locus Names:

Haur_3550

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL ABX06186.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	206	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	259	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	126	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	128	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	136	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	244	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	216	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	228	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	285	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	324	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A9B549 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 27334E04F6706C2F	FASTA	335	36,345
	10 20 30 40 50 60 MSMLESVPTP NRRLRRGRRN ATLRRMVRET QLTVDNLIAP LFIVEGQNIR KPISSMPGQF 70 80 90 100 110 120 QLSLDQLGTE IDELVAAQIP AVLLFGIPLH KDAQGSSAWD ANGPVPSAIR AIKQQAPHLV 130 140 150 160 170 180 VIADVCMCEY TDHGHCGILT SGEPETITVD NDPTLELLAR ASVAYAEAGA DVVAPSAMMD 190 200 210 220 230 240 GQIAAIRYGL DQAGYHDTII LSYAAKFASA FYGPFREAAE STPQFGDRRS YQMDAANARE 250 260 270 280 290 300 AIAETALDVA EGADWLMVKP AGAYLDIIRA VYEEFDLPLA AYQVSGEYAM IKAAAANGWI 310 320 330 DEQRVALESL LAIRRAGASM IITYYAKAAA QWLKA

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000875 Genomic DNA. Translation: ABX06186.1.
RefSeq	YP_001546314.1. NC_009972.1.
3D structure databases
ProteinModelPortal	A9B549.
SMR	A9B549. Positions 12-334.
ModBase	Search...
Protein-protein interaction databases
STRING	A9B549.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5735409.
GenomeReviews	Gene locus Haur_3550 in contig CP000875_GR.
KEGG	hau:Haur_3550.
PATRIC	22124261. VBIHerAur93466_3650.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9B549_HERA2

Accession

Primary (citable) accession number: A9B549

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)