A9B4J6 (T23O_HERA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2,3-dioxygenase
Short name=TDO
EC=1.13.11.11

Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase

Gene names

Name:	kynA
Ordered Locus Names:	Haur_1517

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heme binding Inferred from sequence or structural similarity. Source: UniProtKB tryptophan 2,3-dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Tryptophan 2,3-dioxygenase		PRO_0000360117
Regions
	Region	7 – 11	5	Substrate binding By similarity
	Region	34 – 38	5	Substrate binding By similarity
Sites
	Metal binding	219	1	Iron (heme axial ligand) By similarity
	Binding site	100	1	Substrate By similarity
	Binding site	107	1	Heme By similarity
	Binding site	233	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9B4J6 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 900AE7463FDE204B	FASTA	260	29,916
	10 20 30 40 50 60 MSQALTYASY LKIDELLNLQ TPRSHGPEHD ELLFIVIHQV YELWFKQILH ELDYLCDLLR 70 80 90 100 110 120 ANDTGRANQS IRRILTILKT IVAQVDVMET MTPLQFNAFR GSLESASGFQ SLQFREIEFV 130 140 150 160 170 180 LGYKRPAILQ HFAALPSHER LEQRYQEPSL WDSFLHYLQL NGYAIPSEQI GRDVTQSLVA 190 200 210 220 230 240 SPAIQTILIT VYRQNPLVSN LCERLIDLDE GFQEWRYRHV KMVERTIGMK QGTGGSSGAA 250 260 YLASTIKPFF PDLWAIRADL

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000875 Genomic DNA. Translation: ABX04161.1.
RefSeq	YP_001544289.1. NC_009972.1.
3D structure databases
ProteinModelPortal	A9B4J6.
ModBase	Search...
Protein-protein interaction databases
STRING	A9B4J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5733404.
GenomeReviews	Gene locus Haur_1517 in contig CP000875_GR.
KEGG	hau:Haur_1517.
PATRIC	22120049. VBIHerAur93466_1557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG647485.
OMA	QYREIEF.
ProtClustDB	CLSK946558.
Enzyme and pathway databases
BioCyc	HAUR316274:HAUR_1517-MONOMER.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
KO	K00453.
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_HERA2

Accession

Primary (citable) accession number: A9B4J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program