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A9B4H8

- FTHS_HERA2

UniProt

A9B4H8 - FTHS_HERA2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHAUR316274:GHYA-1521-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Haur_1499
    OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
    Taxonomic identifieri316274 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
    ProteomesiUP000000787: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000146685Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316274.Haur_1499.

    Structurei

    3D structure databases

    ProteinModelPortaliA9B4H8.
    SMRiA9B4H8. Positions 5-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9B4H8-1 [UniParc]FASTAAdd to Basket

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    MKTSLQIAAE ATPRPITQIA EELAIAEQFV EPYGRYRAKI NLDLLDASHD    50
    RPRGKQILVT AMTPTPLGEG KTATTIGLGM ALSRLGKRAI CTLRQSSLGP 100
    VFGIKGGGSG GGYSQVIPLE DSLMHLTGDI HAVTQAHNQI AAMTDNSWYQ 150
    KNRLGIDPEQ IQIRRVLDVN DRFLRSITIG QGGSQHGIPR QTGFDITAAS 200
    ELMAILALVS GENHADVMRD LRQRIGRMVV AFTRQGQPIT ADDIQAAGAA 250
    TVIMRNAIHP TLMQTIENTP VLMHGGPFAN IAHGNASVVA DQVGLRIADY 300
    VVTEAGFAMD MGGEKFFDIK CRAFDAKPAV VVLVATIRAL KAHSGRWNIK 350
    PGRDLPTDLL QENPDAVYAG GANLQKHIRN AQLFGLPVVV ALNSFPDDHP 400
    SEIEAVREIA MSAGAFDVAV SKVFSQGGVG GEELAEKVLA AIDQAGQAQF 450
    LYELEQPLTA KIATIATKIY GAAEVSYSEA ASEQLAKLEA NGFGNLPICM 500
    AKTHLSISHD PALKGAPTGY SFPIREVRAS IGAGFIYPIA GDMMTMPGLS 550
    ANPAAQQIDI DEHGNTVGLF 570
    Length:570
    Mass (Da):60,778
    Last modified:January 15, 2008 - v1
    Checksum:i98957634815C5115
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX04143.1.
    RefSeqiWP_012189049.1. NC_009972.1.
    YP_001544271.1. NC_009972.1.

    Genome annotation databases

    EnsemblBacteriaiABX04143; ABX04143; Haur_1499.
    GeneIDi5733384.
    KEGGihau:Haur_1499.
    PATRICi22120009. VBIHerAur93466_1539.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX04143.1 .
    RefSeqi WP_012189049.1. NC_009972.1.
    YP_001544271.1. NC_009972.1.

    3D structure databases

    ProteinModelPortali A9B4H8.
    SMRi A9B4H8. Positions 5-568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316274.Haur_1499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX04143 ; ABX04143 ; Haur_1499 .
    GeneIDi 5733384.
    KEGGi hau:Haur_1499.
    PATRICi 22120009. VBIHerAur93466_1539.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HAUR316274:GHYA-1521-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Bryant D.A., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23779 / DSM 785.

    Entry informationi

    Entry nameiFTHS_HERA2
    AccessioniPrimary (citable) accession number: A9B4H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3