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A9B4H8 (FTHS_HERA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Haur_1499
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteriaChloroflexiHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146685

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9B4H8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 98957634815C5115

FASTA57060,778
        10         20         30         40         50         60 
MKTSLQIAAE ATPRPITQIA EELAIAEQFV EPYGRYRAKI NLDLLDASHD RPRGKQILVT 

        70         80         90        100        110        120 
AMTPTPLGEG KTATTIGLGM ALSRLGKRAI CTLRQSSLGP VFGIKGGGSG GGYSQVIPLE 

       130        140        150        160        170        180 
DSLMHLTGDI HAVTQAHNQI AAMTDNSWYQ KNRLGIDPEQ IQIRRVLDVN DRFLRSITIG 

       190        200        210        220        230        240 
QGGSQHGIPR QTGFDITAAS ELMAILALVS GENHADVMRD LRQRIGRMVV AFTRQGQPIT 

       250        260        270        280        290        300 
ADDIQAAGAA TVIMRNAIHP TLMQTIENTP VLMHGGPFAN IAHGNASVVA DQVGLRIADY 

       310        320        330        340        350        360 
VVTEAGFAMD MGGEKFFDIK CRAFDAKPAV VVLVATIRAL KAHSGRWNIK PGRDLPTDLL 

       370        380        390        400        410        420 
QENPDAVYAG GANLQKHIRN AQLFGLPVVV ALNSFPDDHP SEIEAVREIA MSAGAFDVAV 

       430        440        450        460        470        480 
SKVFSQGGVG GEELAEKVLA AIDQAGQAQF LYELEQPLTA KIATIATKIY GAAEVSYSEA 

       490        500        510        520        530        540 
ASEQLAKLEA NGFGNLPICM AKTHLSISHD PALKGAPTGY SFPIREVRAS IGAGFIYPIA 

       550        560        570 
GDMMTMPGLS ANPAAQQIDI DEHGNTVGLF 

« Hide

References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000875 Genomic DNA. Translation: ABX04143.1.
RefSeqYP_001544271.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9B4H8.
SMRA9B4H8. Positions 5-568.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316274.Haur_1499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX04143; ABX04143; Haur_1499.
GeneID5733384.
KEGGhau:Haur_1499.
PATRIC22120009. VBIHerAur93466_1539.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycHAUR316274:GHYA-1521-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_HERA2
AccessionPrimary (citable) accession number: A9B4H8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways