A9B4H8 (FTHS_HERA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Haur_1499

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_1000146685
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9B4H8 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 98957634815C5115	FASTA	570	60,778
	10 20 30 40 50 60 MKTSLQIAAE ATPRPITQIA EELAIAEQFV EPYGRYRAKI NLDLLDASHD RPRGKQILVT 70 80 90 100 110 120 AMTPTPLGEG KTATTIGLGM ALSRLGKRAI CTLRQSSLGP VFGIKGGGSG GGYSQVIPLE 130 140 150 160 170 180 DSLMHLTGDI HAVTQAHNQI AAMTDNSWYQ KNRLGIDPEQ IQIRRVLDVN DRFLRSITIG 190 200 210 220 230 240 QGGSQHGIPR QTGFDITAAS ELMAILALVS GENHADVMRD LRQRIGRMVV AFTRQGQPIT 250 260 270 280 290 300 ADDIQAAGAA TVIMRNAIHP TLMQTIENTP VLMHGGPFAN IAHGNASVVA DQVGLRIADY 310 320 330 340 350 360 VVTEAGFAMD MGGEKFFDIK CRAFDAKPAV VVLVATIRAL KAHSGRWNIK PGRDLPTDLL 370 380 390 400 410 420 QENPDAVYAG GANLQKHIRN AQLFGLPVVV ALNSFPDDHP SEIEAVREIA MSAGAFDVAV 430 440 450 460 470 480 SKVFSQGGVG GEELAEKVLA AIDQAGQAQF LYELEQPLTA KIATIATKIY GAAEVSYSEA 490 500 510 520 530 540 ASEQLAKLEA NGFGNLPICM AKTHLSISHD PALKGAPTGY SFPIREVRAS IGAGFIYPIA 550 560 570 GDMMTMPGLS ANPAAQQIDI DEHGNTVGLF

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000875 Genomic DNA. Translation: ABX04143.1.
RefSeq	YP_001544271.1. NC_009972.1.
3D structure databases
ProteinModelPortal	A9B4H8.
SMR	A9B4H8. Positions 5-568.
ModBase	Search...
Protein-protein interaction databases
STRING	A9B4H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5733384.
GenomeReviews	Gene locus Haur_1499 in contig CP000875_GR.
KEGG	hau:Haur_1499.
PATRIC	22120009. VBIHerAur93466_1539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	CLSK983690.
Enzyme and pathway databases
BioCyc	HAUR316274:HAUR_1499-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_HERA2

Accession

Primary (citable) accession number: A9B4H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program