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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHAUR316274:GHYA-1521-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Haur_1499
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
ProteomesiUP000000787 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000146685Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316274.Haur_1499.

Structurei

3D structure databases

ProteinModelPortaliA9B4H8.
SMRiA9B4H8. Positions 5-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9B4H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSLQIAAE ATPRPITQIA EELAIAEQFV EPYGRYRAKI NLDLLDASHD
60 70 80 90 100
RPRGKQILVT AMTPTPLGEG KTATTIGLGM ALSRLGKRAI CTLRQSSLGP
110 120 130 140 150
VFGIKGGGSG GGYSQVIPLE DSLMHLTGDI HAVTQAHNQI AAMTDNSWYQ
160 170 180 190 200
KNRLGIDPEQ IQIRRVLDVN DRFLRSITIG QGGSQHGIPR QTGFDITAAS
210 220 230 240 250
ELMAILALVS GENHADVMRD LRQRIGRMVV AFTRQGQPIT ADDIQAAGAA
260 270 280 290 300
TVIMRNAIHP TLMQTIENTP VLMHGGPFAN IAHGNASVVA DQVGLRIADY
310 320 330 340 350
VVTEAGFAMD MGGEKFFDIK CRAFDAKPAV VVLVATIRAL KAHSGRWNIK
360 370 380 390 400
PGRDLPTDLL QENPDAVYAG GANLQKHIRN AQLFGLPVVV ALNSFPDDHP
410 420 430 440 450
SEIEAVREIA MSAGAFDVAV SKVFSQGGVG GEELAEKVLA AIDQAGQAQF
460 470 480 490 500
LYELEQPLTA KIATIATKIY GAAEVSYSEA ASEQLAKLEA NGFGNLPICM
510 520 530 540 550
AKTHLSISHD PALKGAPTGY SFPIREVRAS IGAGFIYPIA GDMMTMPGLS
560 570
ANPAAQQIDI DEHGNTVGLF
Length:570
Mass (Da):60,778
Last modified:January 15, 2008 - v1
Checksum:i98957634815C5115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000875 Genomic DNA. Translation: ABX04143.1.
RefSeqiWP_012189049.1. NC_009972.1.
YP_001544271.1. NC_009972.1.

Genome annotation databases

EnsemblBacteriaiABX04143; ABX04143; Haur_1499.
KEGGihau:Haur_1499.
PATRICi22120009. VBIHerAur93466_1539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000875 Genomic DNA. Translation: ABX04143.1.
RefSeqiWP_012189049.1. NC_009972.1.
YP_001544271.1. NC_009972.1.

3D structure databases

ProteinModelPortaliA9B4H8.
SMRiA9B4H8. Positions 5-568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316274.Haur_1499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX04143; ABX04143; Haur_1499.
KEGGihau:Haur_1499.
PATRICi22120009. VBIHerAur93466_1539.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciHAUR316274:GHYA-1521-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Bryant D.A., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23779 / DSM 785.

Entry informationi

Entry nameiFTHS_HERA2
AccessioniPrimary (citable) accession number: A9B4H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: April 29, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.