A9B496 (DNAA_HERA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	Haur_0001

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000121988
Regions
	Nucleotide binding	172 – 179	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A9B496 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 1257B0E47CD4EFC5	FASTA	472	52,821
	10 20 30 40 50 60 MDTKQIWFTT LGTLQNQILR YDYDTWLKTT ALVSVANDLA VIGAPNVTTK QVIEDRFMSV 70 80 90 100 110 120 LRRALGEVLG YQVNVRVIIS SATPAPSEPV AVTPSEPSPT TEVAEPSFAS FNQAAPMLNQ 130 140 150 160 170 180 LPLGDPNRSS VLNPRYTFSS FIVGTSNRLA HAACMAVAEH PAQAYNPLFL YGGVGLGKTH 190 200 210 220 230 240 LLQAIGNYAL DRNPEVNVLY VSSEKFTNDL INAIRRQQTE EFRIRYRNID ILLIDDIQFI 250 260 270 280 290 300 AGKEGTQEEF FHTFNTLHGA GKQIVLSSDR PPKAILTLEE RLRSRFEWGL IVDVQNPDLE 310 320 330 340 350 360 TRTAILRAKG ETLQVPVSSE VIDFLAQRIQ SNIRELEGCL NRVIAYANLN RTPVTVEVAS 370 380 390 400 410 420 AALADLLDTS RRKRVTADDI FREVSQHYGI DQRAIRGRGR SRNVVLPRQV VMYLLREETD 430 440 450 460 470 ASLVEIGELL GGRDHTTVMH GYNKITDDLT SDARLRNDIT SLRQRLYGEN AR

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000875 Genomic DNA. Translation: ABX02653.1.
RefSeq	YP_001542781.1. NC_009972.1.
3D structure databases
ProteinModelPortal	A9B496.
ModBase	Search...
Protein-protein interaction databases
STRING	A9B496.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5736835.
GenomeReviews	Gene locus Haur_0001 in contig CP000875_GR.
KEGG	hau:Haur_0001.
PATRIC	22116885. VBIHerAur93466_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	HAUR316274:HAUR_0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_HERA2

Accession

Primary (citable) accession number: A9B496

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program