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A9B406 (DDL_HERA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Haur_3506
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteriaChloroflexiHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000091187

Regions

Domain144 – 350207ATP-grasp
Nucleotide binding177 – 23256ATP By similarity

Sites

Metal binding3031Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 2 By similarity
Metal binding3191Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A9B406 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 67321BC32A3BA1FD

FASTA36139,103
        10         20         30         40         50         60 
MTKRRVGIVF GGKSGEHEVS LKSARAVMNA LDPEKYTVIP IGITRNGQWL SGGDPLLALE 

        70         80         90        100        110        120 
QQADQKMLGR TPQAGVVSET AIVQSAGSLP EQTNVAALDV IIPVLHGPFG EDGTIQGVFE 

       130        140        150        160        170        180 
FANLPYVGCG VLAASVGMDK GLMKSAFAAA GLPQVPWQLV LRRDWQTQPE AVYERLEATL 

       190        200        210        220        230        240 
HYPMFVKPAN LGSSVGISKV SNRAELATGM AEAAGYDRRI VVEQGINARE IEVAILGNDD 

       250        260        270        280        290        300 
PKPSVPGEVL PANDFYDYAD KYLEGQTQFA IPAELDAATS EQLREMAVTA FKAIDGAGLA 

       310        320        330        340        350        360 
RVDFFVERET GAIYINEINT FPGFTAMSQY PKLWEATGLG YSELLDRLID LAIERYHERG 


R 

« Hide

References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000875 Genomic DNA. Translation: ABX06142.1.
RefSeqYP_001546270.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9B406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316274.Haur_3506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX06142; ABX06142; Haur_3506.
GeneID5735367.
KEGGhau:Haur_3506.
PATRIC22124171. VBIHerAur93466_3605.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMARSAYGIY.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycHAUR316274:GHYA-3543-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_HERA2
AccessionPrimary (citable) accession number: A9B406
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways