A9B2Q5 (GCST_HERA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Haur_2868

Organism

Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]

Taxonomic identifier

316274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon › Herpetosiphon aurantiacus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP-Rule MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP-Rule MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Aminomethyltransferase HAMAP-Rule MF_00259		PRO_1000114099

Sequences

	Sequence		Length	Mass (Da)
	A9B2Q5 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: E5371EA3250BEEFB	FASTA	361	39,308
	10 20 30 40 50 60 MKQTPLNARH RALGARMVEF GGWDMPVQYA GIIAEHKATR EGAGLFDISH MARFWVTGPD 70 80 90 100 110 120 SERFIQLIDT FDISKTAIGQ SDYGIMCYED GGIVDDIFTY HLGPDEWMVV ANAGNAEKDW 130 140 150 160 170 180 AWLNQHTAGY DVVLTDRSQE LAMIALQGPK AESLLAPLTD ADVVNLAFHG ITKATVEGAA 190 200 210 220 230 240 GYISRTGYTG EDGFELFLPA GEIERIWDRL LEVGATPIGL GARDSLRFEP GLALYGHEIE 250 260 270 280 290 300 RDINPYEAKL GWVVKLDKGP FIGSEALHDI KANGPVRTLV GLEMTGRGIA RQGYPVVALD 310 320 330 340 350 360 GSELGVVTTG MPSPSLGKNL AYALVKAGSL KIGAEVDVLI REKPVRATVV KTPFYKARYK K

References

[1]

"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Bryant D.A., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000875 Genomic DNA. Translation: ABX05506.1.
RefSeq	YP_001545634.1. NC_009972.1.
3D structure databases
ProteinModelPortal	A9B2Q5.
ModBase	Search...
Protein-protein interaction databases
STRING	316274.Haur_2868.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX05506; ABX05506; Haur_2868.
GeneID	5734739.
KEGG	hau:Haur_2868.
PATRIC	22122835. VBIHerAur93466_2942.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HOG000239381.
KO	K00605.
OMA	GARIVEF.
ProtClustDB	CLSK973608.
Enzyme and pathway databases
BioCyc	HAUR316274:GHYA-3118-MONOMER.
Family and domain databases
Gene3D	3.30.1360.120. 2 hits.
HAMAP	MF_00259. GcvT.
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. IPR027266. TrmE/GcvT_dom1. [Graphical view]
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_HERA2

Accession

Primary (citable) accession number: A9B2Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program