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A9B127

- A9B127_HERA2

UniProt

A9B127 - A9B127_HERA2

Protein

Thymidine kinase

Gene

tdk

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Proton acceptorUniRule annotation
    Metal bindingi141 – 1411ZincUniRule annotation
    Metal bindingi144 – 1441ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi182 – 1821ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPUniRule annotation
    Nucleotide bindingi84 – 874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciHAUR316274:GHYA-2697-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Haur_2667Imported
    OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)Imported
    Taxonomic identifieri316274 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
    ProteomesiUP000000787: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi316274.Haur_2667.

    Structurei

    3D structure databases

    ProteinModelPortaliA9B127.
    SMRiA9B127. Positions 2-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiTMRKTEE.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9B127-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRGGIEVVC GSMFSGKTEE LIRRVKRAQI ARQKIQVFKP AIDTRYSDEE    50
    VASHNGVRVL ATPVQTAADI AAAIALETTV VAIDEVQFFD PAVIDLCDLL 100
    AHRGVRVIVA GLDQDFRGEP FGPLPILLAK AEEVTKLQAI CVICGQAASR 150
    TQRLINGMPA SYDDPIILVG AQEAYEARCR RCHEVPRTYR NGNHAKETAV 200
    NS 202
    Length:202
    Mass (Da):22,069
    Last modified:January 15, 2008 - v1
    Checksum:iCA79FAC5B3BFDFE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX05305.1.
    RefSeqiWP_012190207.1. NC_009972.1.
    YP_001545433.1. NC_009972.1.

    Genome annotation databases

    EnsemblBacteriaiABX05305; ABX05305; Haur_2667.
    GeneIDi5734562.
    KEGGihau:Haur_2667.
    PATRICi22122425. VBIHerAur93466_2738.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX05305.1 .
    RefSeqi WP_012190207.1. NC_009972.1.
    YP_001545433.1. NC_009972.1.

    3D structure databases

    ProteinModelPortali A9B127.
    SMRi A9B127. Positions 2-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316274.Haur_2667.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX05305 ; ABX05305 ; Haur_2667 .
    GeneIDi 5734562.
    KEGGi hau:Haur_2667.
    PATRICi 22122425. VBIHerAur93466_2738.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi TMRKTEE.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci HAUR316274:GHYA-2697-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Bryant D.A., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23779 / DSM 785Imported.

    Entry informationi

    Entry nameiA9B127_HERA2
    AccessioniPrimary (citable) accession number: A9B127
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3