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A9B127

- A9B127_HERA2

UniProt

A9B127 - A9B127_HERA2

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Protein

Thymidine kinase

Gene
tdk, Haur_2667
Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Proton acceptor By similarityUniRule annotation
Metal bindingi141 – 1411Zinc By similarityUniRule annotation
Metal bindingi144 – 1441Zinc By similarityUniRule annotation
Metal bindingi179 – 1791Zinc By similarityUniRule annotation
Metal bindingi182 – 1821Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP By similarityUniRule annotation
Nucleotide bindingi84 – 874ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHAUR316274:GHYA-2697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Haur_2667Imported
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)Imported
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
ProteomesiUP000000787: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi316274.Haur_2667.

Structurei

3D structure databases

ProteinModelPortaliA9B127.
SMRiA9B127. Positions 2-186.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiTMRKTEE.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9B127-1 [UniParc]FASTAAdd to Basket

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MQRGGIEVVC GSMFSGKTEE LIRRVKRAQI ARQKIQVFKP AIDTRYSDEE    50
VASHNGVRVL ATPVQTAADI AAAIALETTV VAIDEVQFFD PAVIDLCDLL 100
AHRGVRVIVA GLDQDFRGEP FGPLPILLAK AEEVTKLQAI CVICGQAASR 150
TQRLINGMPA SYDDPIILVG AQEAYEARCR RCHEVPRTYR NGNHAKETAV 200
NS 202
Length:202
Mass (Da):22,069
Last modified:January 15, 2008 - v1
Checksum:iCA79FAC5B3BFDFE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX05305.1.
RefSeqiWP_012190207.1. NC_009972.1.
YP_001545433.1. NC_009972.1.

Genome annotation databases

EnsemblBacteriaiABX05305; ABX05305; Haur_2667.
GeneIDi5734562.
KEGGihau:Haur_2667.
PATRICi22122425. VBIHerAur93466_2738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX05305.1 .
RefSeqi WP_012190207.1. NC_009972.1.
YP_001545433.1. NC_009972.1.

3D structure databases

ProteinModelPortali A9B127.
SMRi A9B127. Positions 2-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316274.Haur_2667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX05305 ; ABX05305 ; Haur_2667 .
GeneIDi 5734562.
KEGGi hau:Haur_2667.
PATRICi 22122425. VBIHerAur93466_2738.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi TMRKTEE.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci HAUR316274:GHYA-2697-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Bryant D.A., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23779 / DSM 785.

Entry informationi

Entry nameiA9B127_HERA2
AccessioniPrimary (citable) accession number: A9B127
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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