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A9AZE0

- THIM_HERA2

UniProt

A9AZE0 - THIM_HERA2

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461Substrate; via amide nitrogenUniRule annotation
    Binding sitei120 – 1201ATPUniRule annotation
    Binding sitei166 – 1661ATPUniRule annotation
    Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHAUR316274:GHYA-2472-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:Haur_2444
    OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
    Taxonomic identifieri316274 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
    ProteomesiUP000000787: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Hydroxyethylthiazole kinasePRO_0000383867Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316274.Haur_2444.

    Structurei

    3D structure databases

    ProteinModelPortaliA9AZE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiGAFCAVQ.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9AZE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTPSSIADC WHSLRQQRPL VHVVPNLVTA NDLANALLAV GAAPIMAIEP    50
    AEFSQLPNRA LVLSMGTPTI DRMQLLAQAG RAAQAKNLPI VLDPVGVGAT 100
    VWRKQAALAL IATVQPTILR LNLGEALALL DQTGVAHGVD VGHAWHDPRL 150
    VAGQLARRYG CVVGLTGVID VVSDGMNWIQ LEHGHQWLSQ ITGAGCIVTS 200
    LIGALAAVIN DVMLATVSAI AGFGMAAEVA AMHALGPASF RVALFDQLGA 250
    IAELIDNSRL SYRMEQHDAD 270
    Length:270
    Mass (Da):28,423
    Last modified:January 15, 2008 - v1
    Checksum:i04E91E7406636E90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX05084.1.
    RefSeqiYP_001545212.1. NC_009972.1.

    Genome annotation databases

    EnsemblBacteriaiABX05084; ABX05084; Haur_2444.
    GeneIDi5734325.
    KEGGihau:Haur_2444.
    PATRICi22121961. VBIHerAur93466_2509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX05084.1 .
    RefSeqi YP_001545212.1. NC_009972.1.

    3D structure databases

    ProteinModelPortali A9AZE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316274.Haur_2444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX05084 ; ABX05084 ; Haur_2444 .
    GeneIDi 5734325.
    KEGGi hau:Haur_2444.
    PATRICi 22121961. VBIHerAur93466_2509.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi GAFCAVQ.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci HAUR316274:GHYA-2472-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Bryant D.A., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23779 / DSM 785.

    Entry informationi

    Entry nameiTHIM_HERA2
    AccessioniPrimary (citable) accession number: A9AZE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3