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A9AZ52 (A9AZ52_HERA2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405
Gene names
Ordered Locus Names:Haur_0950
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Herpetosiphonales › Herpetosiphonaceae › Herpetosiphon

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP MF_01405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP MF_01405
Region70 – 712Substrate binding By similarity HAMAP MF_01405

Sites

Metal binding411Magnesium or manganese By similarity HAMAP MF_01405
Metal binding701Magnesium or manganese By similarity HAMAP MF_01405
Binding site1571Substrate By similarity HAMAP MF_01405
Binding site1771Substrate By similarity HAMAP MF_01405
Binding site1831Substrate By similarity HAMAP MF_01405

Sequences

Sequence LengthMass (Da)Tools
A9AZ52 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: E44B12B3AE4043BA

FASTA19921,808
        10         20         30         40         50         60 
MQKLLIGSNN AHKVGELRAI FSGLPFELLT LADAGIDYEV EETGTTFVEN ARLKAETYAQ 

        70         80         90        100        110        120 
ISGLPTLADD SGLEVAALDG KPGIYTARWA LPDLNNPHRA YARVLEELKG KPFHDRIARF 

       130        140        150        160        170        180 
VCVIAIAWPG QPTEVVEGIL PGVIAEEPRG VGGFGYDPVF YLLDYDKHLA ELDPEEKNRI 

       190 
SHRGQACALA REVLELLAK

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References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000875 Genomic DNA. Translation: ABX03598.1.
RefSeqYP_001543726.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9AZ52.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9AZ52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5732836.
GenomeReviewsGene locus Haur_0950 in contig CP000875_GR.
KEGGhau:Haur_0950.
PATRIC22118851. VBIHerAur93466_0969.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697237.
OMAGVYTADW.
ProtClustDBCLSK974075.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9AZ52_HERA2
AccessionPrimary (citable) accession number: A9AZ52
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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