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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei585ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Haur_4419
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
Proteomesi
  • UP000000787 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001992101 – 814Leucine--tRNA ligaseAdd BLAST814

Proteomic databases

PRIDEiA9AZ11

Interactioni

Protein-protein interaction databases

STRINGi316274.Haur_4419

Structurei

3D structure databases

ProteinModelPortaliA9AZ11
SMRiA9AZ11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi582 – 586"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A9AZ11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRYDSSIT EPKWRERWER DGIYRFEPDS DKPKHYAVTM LPYPSGNLHI
60 70 80 90 100
GHWYAMSPSD VHARYMRMRG YNVFFPMGFD AFGLPAENAA IKNNLDPRKW
110 120 130 140 150
TYSNIEYMRG QLQSMGMMVD WDQQIVSADP EYYRWNQWFF IQFFKRGLAY
160 170 180 190 200
KKFSAVDWCP KCNTTLAREQ VVGDERRCER CDSLVTKRDL DQWYFKITSY
210 220 230 240 250
ADELLNFSEL DWPERITTMQ RNWIGRSEGA EISFKSEAGD PITVFSTRPD
260 270 280 290 300
TLWGATFMVL APEHPLVAKL TSAEQKASVD AYVAEAIRKT EVERQSTDDE
310 320 330 340 350
KPKTGVWIGA YAINPASQER VPIWIADYVL MTYGTGAIMA VPGHDERDFA
360 370 380 390 400
FAKTFGLAIK RVVTQSEQTA ETPLEAAEPA YGTVVNSGQI DGLSSAEAKE
410 420 430 440 450
AVINWLEAEQ LGKRAINYRL RDWLVSRQRY WGTPIPMIYC PTCGTVPVPE
460 470 480 490 500
DQLPLLLPDS VDFKPTGESP LKLHPTWRFT TCPTCGGEAE RDTDTMDTFV
510 520 530 540 550
DSSWYQVRYL SPHETNAPFT KAIADKWLPV DQYTGGREHA VMHLLYTRFW
560 570 580 590 600
WKAMRDMGLV SANEPMTRLI NQGVILGEDS NKMSKSRGNV IDPDMLVAQY
610 620 630 640 650
GADTVRTFLM FIGPWEQGGP WNNRGIEGCV RFLDRAWRVV TDTPQRHDAV
660 670 680 690 700
GDASTLERQT HRIIKKVGDD LQRFAFNTAI AGLMEFVNEL MKVRETDVYG
710 720 730 740 750
TTTWRKATET LTLLLAPIAP HIAEELWEFL GNSQSVHLQA WPSYDETLLI
760 770 780 790 800
DESIELPVQI NGKVRGKIQV AATADEPSII ATALADEKIA PLVAGKTIVK
810
QIVVPNRLVN IVIK
Length:814
Mass (Da):92,643
Last modified:January 15, 2008 - v1
Checksum:i18C920705770E083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000875 Genomic DNA Translation: ABX07051.1

Genome annotation databases

EnsemblBacteriaiABX07051; ABX07051; Haur_4419
KEGGihau:Haur_4419

Similar proteinsi

Entry informationi

Entry nameiSYL_HERA2
AccessioniPrimary (citable) accession number: A9AZ11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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