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A9AZ11

- SYL_HERA2

UniProt

A9AZ11 - SYL_HERA2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei585 – 5851ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHAUR316274:GHYA-4474-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Haur_4419
    OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
    Taxonomic identifieri316274 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
    ProteomesiUP000000787: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 814814Leucine--tRNA ligasePRO_1000199210Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316274.Haur_4419.

    Structurei

    3D structure databases

    ProteinModelPortaliA9AZ11.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi582 – 5865"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9AZ11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRYDSSIT EPKWRERWER DGIYRFEPDS DKPKHYAVTM LPYPSGNLHI    50
    GHWYAMSPSD VHARYMRMRG YNVFFPMGFD AFGLPAENAA IKNNLDPRKW 100
    TYSNIEYMRG QLQSMGMMVD WDQQIVSADP EYYRWNQWFF IQFFKRGLAY 150
    KKFSAVDWCP KCNTTLAREQ VVGDERRCER CDSLVTKRDL DQWYFKITSY 200
    ADELLNFSEL DWPERITTMQ RNWIGRSEGA EISFKSEAGD PITVFSTRPD 250
    TLWGATFMVL APEHPLVAKL TSAEQKASVD AYVAEAIRKT EVERQSTDDE 300
    KPKTGVWIGA YAINPASQER VPIWIADYVL MTYGTGAIMA VPGHDERDFA 350
    FAKTFGLAIK RVVTQSEQTA ETPLEAAEPA YGTVVNSGQI DGLSSAEAKE 400
    AVINWLEAEQ LGKRAINYRL RDWLVSRQRY WGTPIPMIYC PTCGTVPVPE 450
    DQLPLLLPDS VDFKPTGESP LKLHPTWRFT TCPTCGGEAE RDTDTMDTFV 500
    DSSWYQVRYL SPHETNAPFT KAIADKWLPV DQYTGGREHA VMHLLYTRFW 550
    WKAMRDMGLV SANEPMTRLI NQGVILGEDS NKMSKSRGNV IDPDMLVAQY 600
    GADTVRTFLM FIGPWEQGGP WNNRGIEGCV RFLDRAWRVV TDTPQRHDAV 650
    GDASTLERQT HRIIKKVGDD LQRFAFNTAI AGLMEFVNEL MKVRETDVYG 700
    TTTWRKATET LTLLLAPIAP HIAEELWEFL GNSQSVHLQA WPSYDETLLI 750
    DESIELPVQI NGKVRGKIQV AATADEPSII ATALADEKIA PLVAGKTIVK 800
    QIVVPNRLVN IVIK 814
    Length:814
    Mass (Da):92,643
    Last modified:January 15, 2008 - v1
    Checksum:i18C920705770E083
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX07051.1.
    RefSeqiYP_001547179.1. NC_009972.1.

    Genome annotation databases

    EnsemblBacteriaiABX07051; ABX07051; Haur_4419.
    GeneIDi5736270.
    KEGGihau:Haur_4419.
    PATRICi22126093. VBIHerAur93466_4550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000875 Genomic DNA. Translation: ABX07051.1 .
    RefSeqi YP_001547179.1. NC_009972.1.

    3D structure databases

    ProteinModelPortali A9AZ11.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316274.Haur_4419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX07051 ; ABX07051 ; Haur_4419 .
    GeneIDi 5736270.
    KEGGi hau:Haur_4419.
    PATRICi 22126093. VBIHerAur93466_4550.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HAUR316274:GHYA-4474-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Bryant D.A., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23779 / DSM 785.

    Entry informationi

    Entry nameiSYL_HERA2
    AccessioniPrimary (citable) accession number: A9AZ11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3