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A9AZ11

- SYL_HERA2

UniProt

A9AZ11 - SYL_HERA2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHAUR316274:GHYA-4474-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Haur_4419
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
ProteomesiUP000000787: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Leucine--tRNA ligasePRO_1000199210Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316274.Haur_4419.

Structurei

3D structure databases

ProteinModelPortaliA9AZ11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi582 – 5865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A9AZ11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATRYDSSIT EPKWRERWER DGIYRFEPDS DKPKHYAVTM LPYPSGNLHI
60 70 80 90 100
GHWYAMSPSD VHARYMRMRG YNVFFPMGFD AFGLPAENAA IKNNLDPRKW
110 120 130 140 150
TYSNIEYMRG QLQSMGMMVD WDQQIVSADP EYYRWNQWFF IQFFKRGLAY
160 170 180 190 200
KKFSAVDWCP KCNTTLAREQ VVGDERRCER CDSLVTKRDL DQWYFKITSY
210 220 230 240 250
ADELLNFSEL DWPERITTMQ RNWIGRSEGA EISFKSEAGD PITVFSTRPD
260 270 280 290 300
TLWGATFMVL APEHPLVAKL TSAEQKASVD AYVAEAIRKT EVERQSTDDE
310 320 330 340 350
KPKTGVWIGA YAINPASQER VPIWIADYVL MTYGTGAIMA VPGHDERDFA
360 370 380 390 400
FAKTFGLAIK RVVTQSEQTA ETPLEAAEPA YGTVVNSGQI DGLSSAEAKE
410 420 430 440 450
AVINWLEAEQ LGKRAINYRL RDWLVSRQRY WGTPIPMIYC PTCGTVPVPE
460 470 480 490 500
DQLPLLLPDS VDFKPTGESP LKLHPTWRFT TCPTCGGEAE RDTDTMDTFV
510 520 530 540 550
DSSWYQVRYL SPHETNAPFT KAIADKWLPV DQYTGGREHA VMHLLYTRFW
560 570 580 590 600
WKAMRDMGLV SANEPMTRLI NQGVILGEDS NKMSKSRGNV IDPDMLVAQY
610 620 630 640 650
GADTVRTFLM FIGPWEQGGP WNNRGIEGCV RFLDRAWRVV TDTPQRHDAV
660 670 680 690 700
GDASTLERQT HRIIKKVGDD LQRFAFNTAI AGLMEFVNEL MKVRETDVYG
710 720 730 740 750
TTTWRKATET LTLLLAPIAP HIAEELWEFL GNSQSVHLQA WPSYDETLLI
760 770 780 790 800
DESIELPVQI NGKVRGKIQV AATADEPSII ATALADEKIA PLVAGKTIVK
810
QIVVPNRLVN IVIK
Length:814
Mass (Da):92,643
Last modified:January 15, 2008 - v1
Checksum:i18C920705770E083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000875 Genomic DNA. Translation: ABX07051.1.
RefSeqiWP_012191943.1. NC_009972.1.
YP_001547179.1. NC_009972.1.

Genome annotation databases

EnsemblBacteriaiABX07051; ABX07051; Haur_4419.
GeneIDi5736270.
KEGGihau:Haur_4419.
PATRICi22126093. VBIHerAur93466_4550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000875 Genomic DNA. Translation: ABX07051.1 .
RefSeqi WP_012191943.1. NC_009972.1.
YP_001547179.1. NC_009972.1.

3D structure databases

ProteinModelPortali A9AZ11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316274.Haur_4419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX07051 ; ABX07051 ; Haur_4419 .
GeneIDi 5736270.
KEGGi hau:Haur_4419.
PATRICi 22126093. VBIHerAur93466_4550.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HAUR316274:GHYA-4474-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Bryant D.A., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23779 / DSM 785.

Entry informationi

Entry nameiSYL_HERA2
AccessioniPrimary (citable) accession number: A9AZ11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3