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A9AZ11

- SYL_HERA2

UniProt

A9AZ11 - SYL_HERA2

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Protein
Leucine--tRNA ligase
Gene
leuS, Haur_4419
Organism
Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHAUR316274:GHYA-4474-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Haur_4419
OrganismiHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
Taxonomic identifieri316274 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon
ProteomesiUP000000787: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Leucine--tRNA ligaseUniRule annotation
PRO_1000199210Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316274.Haur_4419.

Structurei

3D structure databases

ProteinModelPortaliA9AZ11.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi582 – 5865"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A9AZ11-1 [UniParc]FASTAAdd to Basket

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MATRYDSSIT EPKWRERWER DGIYRFEPDS DKPKHYAVTM LPYPSGNLHI    50
GHWYAMSPSD VHARYMRMRG YNVFFPMGFD AFGLPAENAA IKNNLDPRKW 100
TYSNIEYMRG QLQSMGMMVD WDQQIVSADP EYYRWNQWFF IQFFKRGLAY 150
KKFSAVDWCP KCNTTLAREQ VVGDERRCER CDSLVTKRDL DQWYFKITSY 200
ADELLNFSEL DWPERITTMQ RNWIGRSEGA EISFKSEAGD PITVFSTRPD 250
TLWGATFMVL APEHPLVAKL TSAEQKASVD AYVAEAIRKT EVERQSTDDE 300
KPKTGVWIGA YAINPASQER VPIWIADYVL MTYGTGAIMA VPGHDERDFA 350
FAKTFGLAIK RVVTQSEQTA ETPLEAAEPA YGTVVNSGQI DGLSSAEAKE 400
AVINWLEAEQ LGKRAINYRL RDWLVSRQRY WGTPIPMIYC PTCGTVPVPE 450
DQLPLLLPDS VDFKPTGESP LKLHPTWRFT TCPTCGGEAE RDTDTMDTFV 500
DSSWYQVRYL SPHETNAPFT KAIADKWLPV DQYTGGREHA VMHLLYTRFW 550
WKAMRDMGLV SANEPMTRLI NQGVILGEDS NKMSKSRGNV IDPDMLVAQY 600
GADTVRTFLM FIGPWEQGGP WNNRGIEGCV RFLDRAWRVV TDTPQRHDAV 650
GDASTLERQT HRIIKKVGDD LQRFAFNTAI AGLMEFVNEL MKVRETDVYG 700
TTTWRKATET LTLLLAPIAP HIAEELWEFL GNSQSVHLQA WPSYDETLLI 750
DESIELPVQI NGKVRGKIQV AATADEPSII ATALADEKIA PLVAGKTIVK 800
QIVVPNRLVN IVIK 814
Length:814
Mass (Da):92,643
Last modified:January 15, 2008 - v1
Checksum:i18C920705770E083
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX07051.1.
RefSeqiYP_001547179.1. NC_009972.1.

Genome annotation databases

EnsemblBacteriaiABX07051; ABX07051; Haur_4419.
GeneIDi5736270.
KEGGihau:Haur_4419.
PATRICi22126093. VBIHerAur93466_4550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000875 Genomic DNA. Translation: ABX07051.1 .
RefSeqi YP_001547179.1. NC_009972.1.

3D structure databases

ProteinModelPortali A9AZ11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316274.Haur_4419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX07051 ; ABX07051 ; Haur_4419 .
GeneIDi 5736270.
KEGGi hau:Haur_4419.
PATRICi 22126093. VBIHerAur93466_4550.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HAUR316274:GHYA-4474-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Bryant D.A., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23779 / DSM 785.

Entry informationi

Entry nameiSYL_HERA2
AccessioniPrimary (citable) accession number: A9AZ11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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