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A9AZ11 (SYL_HERA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Haur_4419
OrganismHerpetosiphon aurantiacus (strain ATCC 23779 / DSM 785) [Complete proteome] [HAMAP]
Taxonomic identifier316274 [NCBI]
Taxonomic lineageBacteriaChloroflexiHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000199210

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif582 – 5865"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5851ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9AZ11 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 18C920705770E083

FASTA81492,643
        10         20         30         40         50         60 
MATRYDSSIT EPKWRERWER DGIYRFEPDS DKPKHYAVTM LPYPSGNLHI GHWYAMSPSD 

        70         80         90        100        110        120 
VHARYMRMRG YNVFFPMGFD AFGLPAENAA IKNNLDPRKW TYSNIEYMRG QLQSMGMMVD 

       130        140        150        160        170        180 
WDQQIVSADP EYYRWNQWFF IQFFKRGLAY KKFSAVDWCP KCNTTLAREQ VVGDERRCER 

       190        200        210        220        230        240 
CDSLVTKRDL DQWYFKITSY ADELLNFSEL DWPERITTMQ RNWIGRSEGA EISFKSEAGD 

       250        260        270        280        290        300 
PITVFSTRPD TLWGATFMVL APEHPLVAKL TSAEQKASVD AYVAEAIRKT EVERQSTDDE 

       310        320        330        340        350        360 
KPKTGVWIGA YAINPASQER VPIWIADYVL MTYGTGAIMA VPGHDERDFA FAKTFGLAIK 

       370        380        390        400        410        420 
RVVTQSEQTA ETPLEAAEPA YGTVVNSGQI DGLSSAEAKE AVINWLEAEQ LGKRAINYRL 

       430        440        450        460        470        480 
RDWLVSRQRY WGTPIPMIYC PTCGTVPVPE DQLPLLLPDS VDFKPTGESP LKLHPTWRFT 

       490        500        510        520        530        540 
TCPTCGGEAE RDTDTMDTFV DSSWYQVRYL SPHETNAPFT KAIADKWLPV DQYTGGREHA 

       550        560        570        580        590        600 
VMHLLYTRFW WKAMRDMGLV SANEPMTRLI NQGVILGEDS NKMSKSRGNV IDPDMLVAQY 

       610        620        630        640        650        660 
GADTVRTFLM FIGPWEQGGP WNNRGIEGCV RFLDRAWRVV TDTPQRHDAV GDASTLERQT 

       670        680        690        700        710        720 
HRIIKKVGDD LQRFAFNTAI AGLMEFVNEL MKVRETDVYG TTTWRKATET LTLLLAPIAP 

       730        740        750        760        770        780 
HIAEELWEFL GNSQSVHLQA WPSYDETLLI DESIELPVQI NGKVRGKIQV AATADEPSII 

       790        800        810 
ATALADEKIA PLVAGKTIVK QIVVPNRLVN IVIK 

« Hide

References

[1]"Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Bryant D.A., Richardson P.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23779 / DSM 785.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000875 Genomic DNA. Translation: ABX07051.1.
RefSeqYP_001547179.1. NC_009972.1.

3D structure databases

ProteinModelPortalA9AZ11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316274.Haur_4419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX07051; ABX07051; Haur_4419.
GeneID5736270.
KEGGhau:Haur_4419.
PATRIC22126093. VBIHerAur93466_4550.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycHAUR316274:GHYA-4474-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_HERA2
AccessionPrimary (citable) accession number: A9AZ11
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries